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G-CSF

Brief Information

Name:Granulocyte colony-stimulating factor
Target Synonym:Granulocyte colony-stimulating factor,Filgrastim,CSF3,Colony Stimulating Factor 3,Pluripoietin,Lenograstim,Colony Stimulating Factor 3 (Granulocyte),C17orf33,GCSF,Granulocyte-Colony Stimulating Factor,Granulocyte Colony Stimulating Factor,Chromosome 17 Op
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
GCF-H5214 Human ActiveMax® Human G-CSF Protein, Tag Free
GCF-H5214-structure
GCF-H5214-sds
GCF-H5214-elisa_1

Part of Bioactivity data

GCF-H5214-MALS-HPLC
ActiveMax® Human G-CSF, Tag FreeActiveMax® Human G-CSF, Tag Free (Cat. No. GCF-H5214) ELISA bioactivity

Immobilized ActiveMax® Human G-CSF, Tag Free (Cat. No. GCF-H5214) at 2 μg/mL (100 μL/well) can bind Biotinylated Human G-CSF R, Avitag,His Tag (Cat. No. GCR-H82E4) with a linear range of 0.156-1.25 μg/mL (QC tested).

Synonym Name

G-CSF,CSF3,C17orf33,CSF3OS,MGC45931

Background

Granulocyte colony-stimulating factor (G-CSF or GCSF) is also known as colony-stimulating factor 3, CSF3, C17orf33, CSF3OS, GCSF, MGC45931. It is a glycoprotein, growth factor and cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to release them into the blood. G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. G-CSF regulates them using Janus kinase (JAK)/signal transducer and activator of transcription (STAT) and Ras /mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signal transduction pathway. G-CSF is produced by endothelium, macrophages, and a number of other immune cells. The natural human glycoprotein exists in two forms, a 174- and 180-amino-acid-long protein of molecular weight 19,600

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Filgrastim biosimilar (Pharmapark) Approved Pharmapark Neutropenia Pharmapark 2008-01-01 Neutropenia Details

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