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Your Position: Home > G-CSF

G-CSF

Brief Information

Name:Granulocyte colony-stimulating factor
Target Synonym:Granulocyte colony-stimulating factor,Filgrastim,CSF3,Colony Stimulating Factor 3,Pluripoietin,Lenograstim,Colony Stimulating Factor 3 (Granulocyte),C17orf33,GCSF,Granulocyte-Colony Stimulating Factor,Granulocyte Colony Stimulating Factor,Chromosome 17 Open Reading Frame 33,CSF3OS,G-CSF,MGC45931
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
GCF-H5214 Human ActiveMax® Human G-CSF Protein, Tag Free
GCF-H5214-structure
GCF-H5214-sds
GCF-H5214-elisa_1

Part of Bioactivity data

GCF-H5214-MALS-HPLC
ActiveMax® Human G-CSF, Tag FreeActiveMax® Human G-CSF, Tag Free (Cat. No. GCF-H5214) ELISA bioactivity

Immobilized ActiveMax® Human G-CSF, Tag Free (Cat. No. GCF-H5214) at 2 μg/mL (100 μL/well) can bind Biotinylated Human G-CSF R, Avitag,His Tag (Cat. No. GCR-H82E4) with a linear range of 0.156-1.25 μg/mL (QC tested).

Synonym Name

G-CSF,CSF3,C17orf33,CSF3OS,MGC45931

Background

Granulocyte colony-stimulating factor (G-CSF or GCSF) is also known as colony-stimulating factor 3, CSF3, C17orf33, CSF3OS, GCSF, MGC45931. It is a glycoprotein, growth factor and cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to release them into the blood. G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. G-CSF regulates them using Janus kinase (JAK)/signal transducer and activator of transcription (STAT) and Ras /mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signal transduction pathway. G-CSF is produced by endothelium, macrophages, and a number of other immune cells. The natural human glycoprotein exists in two forms, a 174- and 180-amino-acid-long protein of molecular weight 19,600

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Eflepedocokin alfa F-652 Phase 2 Clinical Evive Biotech Ltd Hepatitis, Alcoholic; Pancreatitis; Coronavirus Disease 2019 (COVID-19); Graft vs Host Disease; Acute-On-Chronic Liver Failure Details

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