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GFR alpha-1

GFR alpha-1 Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
GF1-H5252 Human Human GFR alpha-1 Protein, Fc Tag
GF1-H5252-structure
GF1-H5252-sds
GF1-H5224 Human Human GFR alpha-1 Protein
GF1-H5224-structure
GF1-H5224-sds

GFR alpha-1 Molecule Synonym Name

GFRA1,GDNFRA,RETL1,TRNR1,GDNFR,GFR-ALPHA-1,RET1L

GFR alpha-1 Molecule Background

GDNF family receptor alpha-1 (GFRA1) is also known as RET ligand 1 (RETL1), TGF-beta-related neurotrophic factor receptor 1 (TRNR1), is a novel glycosylphosphatidylinositol (GPI)-linked cell surface receptor, and belongs to the glial cell line-derived neurotrophic factor (GDNF) receptor subfamily. The GDNF family ligands comprises GDNF, Neurturin (NTN), Artemin, and Persephin. GDNF and NTN are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA1 mediates the association with and activation of the RET tyrosine kinase receptor (RTK), and subsequently initiates the RET signaling pathway. GFR alpha-mediated signaling plays an important role in the survival, differentiation, and migration of central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system, as well as the inflammatory response in some carciniomas.

GFR alpha-1 References

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