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Explore our series of high-quality proteins covering comprehensive diagnostic indicators in order to facilitate the in vitro diagnostic research of neurological diseases.
Pre-formed fibrils are an invaluable preclinical model for exploring pathogenesis of neurological diseases through aggregation of misfolded proteins. Explore our pre-seeded PFFs to use in your research.
Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. Explore our series of recombinant neural factors to support the culture and differentiation of nerve cells.
Partnering with Diagnostic Biochips, we now provide solutions for in vivo electrophysiology recordings, including high-quality multi-channel electrodes and other products to facilitate high-quality, efficient analysis of neural circuit structure and function.
Neural antibodies can specifically label and recognize molecules on nerve cells, enabling a more comprehensive understanding and study of the biological properties, functions, and mechanisms of nerve cells in neurodegenerative diseases.
Protein markers are an essential component in biological research and drug development. Whether it is for protein electrophoresis or western blot, our pre-stained protein markers help you quickly determine the molecular weight of the target protein or evaluate the transfer efficiency.
Streptavidin is a tetrameric protein providing 4 high-affinity biotin binding sites. We offer a wide array of products pre-conjugated with streptavidin to support your research as well as biotinylated proteins.
Setting the corresponding isotype control antibody to detect non-specific binding can reduce the generation of false positive results and evaluate the possible influencing factors accurately in the drug development process. Explore our isotype controls for your research.
The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. Explore our comprehensive collection of recombinant Fc receptor proteins!
We committed to accelerating the research, development, approval, and commercialization of infectious disease vaccines. With this idea, ViruStop is specially designed for virus research!
Name:Hypoxia-inducible factor 1 alpha Target Synonym:ARNT Interacting Protein,HIF-1A,HIF1,Hypoxia-Inducible Factor 1, alpha Subunit,MOP1,HIF-1-alpha,BHLHE78,ARNT-interacting protein,Class E basic helix-loop-helix protein 78,PASD8,HIF1-alpha,HIF1A,Hypoxia Inducible Factor 1 Subunit Alpha,Hypoxia Inducible Fa
Number of Launched Drugs:0 Number of Drugs in Clinical Trials:3 Lastest Research Phase:Phase 2 Clinical
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Synonym Name
HIF-1alpha,HIF1a,MOP1,PASD8,bHLHe78
Background
Hypoxia-inducible factor 1, alpha subunit is also known as ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, PAS domain-containing protein 8, Class E basic helix-loop-helix protein 78 and HIF1A, is a cytoplasm and nucleus protein. HIF1A contains one basic helix-loop-helix (bHLH) domain, one PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. It is expressed in most tissues with highest levels in kidney and heart. is a bHLH - PAS transcription factor found in mammalian cells growing at low oxygen concentrations. It plays an essential role in cellular and systemic responses to hypoxia. This is one of the class of hypoxia inducible factors, a family that includes Hif1a, Hif2a, and Hif3a. HIF1A activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF1A plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. HIF1A interacts with the HIF1A beta / ARNT subunit. Heterodimerization of HIF1A is required for DNA binding. HIF1A interacts with COPS5. The interaction increases the transcriptional activity of HIF1A through increased stability.
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