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beta 2-Microglobulin

beta 2-Microglobulin Molecule Information

Target Synonym:HDCMA22P,CDABP0092,B2M,Beta-2-Microglobulin,Beta Chain Of MHC Class I Molecules,Beta-2-Microglobin,IMD43,beta 2-Microglobulin
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Discontinued

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Cat. No. Species Product Description Structure Purity Feature
B2M-C5226 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque beta 2-Microglobulin / B2M Protein, His Tag
B2M-R5229 Rat Rat beta 2-Microglobulin / B2M Protein, His Tag
B2M-H5225 Human Human beta 2-Microglobulin / B2M Protein, His Tag

beta 2-Microglobulin Molecule Synonym Name


beta 2-Microglobulin Molecule Background

¦Â2 microglobulin is also known as Beta-2-microglobulin (B2M), is a component of MHC class I molecules which belongs to the beta-2-microglobulin family. B2M is present on all nucleated cells (excludes red blood cells). B2M associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa. An additional function of B2M is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic membrane of enterocytes and macrophages for degradation resulting in decreased iron uptake from food and iron release from recycled red blood cells respectively. Loss of this function causes iron excess and hemochromatosis. Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP).

beta 2-Microglobulin References

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