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Brief Information

Name:Tumor necrosis factor receptor superfamily member 14
Target Synonym:Herpes virus entry mediator A,Herpesvirus entry mediator A,HveA,Tumor necrosis factor receptor-like 2,TR2,CD270,HVEM
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Part of Bioactivity data

CHEK-ATP147-Cell-based assay

Expression analysis of human HVEM on HEK293/Human HVEM Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human HVEM Stable Cell Line or negative control cell using APC-labeled anti-human HVEM antibody.

SCRAJ-STF108-Cell-based assay

Expression analysis of human HVEM on Raji/Human HVEM Stable Cell Line by FACS.
Raji/Human HVEM Stable Cell Line or negative control cell were stained with PE-labeled anti-Human HVEM antibody.


Loaded Human HVEM, Fc Tag (Cat. No. HVM-H5258) on Protein A Biosensor, can bind Human CD160, His Tag (Cat. No. BY5-H5229) with an affinity constant of 0.44 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).


Immobilized Human LIGHT, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. LIT-H5256) at 2 μg/mL (100 μL/well) can bind Biotinylated Human HVEM, Fc,Avitag (Cat. No. HVM-H82F6) with a linear range of 0.6-39 ng/mL (QC tested).

Synonym Name



Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNF¦Â (lymphotoxin ¦Á) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LT¦ÂR, the receptor for lymphotoxin ¦Á¦Â heterotrimer. The role of the HVEM LIGHT /LT¦Â receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.

Clinical and Translational Updates

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