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Your Position: Home > IFN-alpha/beta R1

IFN-alpha/beta R1

Brief Information

Name:Interferon-alpha/beta receptor alpha chain
Target Synonym:CRF2-1,IFN-R-1,Cytokine Receptor Family 2 Member 1,Interferon-Alpha/Beta Receptor Alpha Chain,Cytokine Receptor Class-II Member 1,Interferon Receptor 1,IFNAR1,Interferon Alpha/Beta Receptor 1,IFN-Alpha-REC,Beta-Type Antiviral Protein,IFNAR,IFNBR,Interfero
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

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Part of Bioactivity data

IF1-H5225-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IFNAR1, His Tag (Cat. No. IF1-H5225) on NTA Biosensor, can bind Human IFN-alpha 2b (K46R), Fc Tag (Cat. No. IFB-H5253) with an affinity constant of 0.689 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

IF1-H5253-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IFN-alpha 1, His Tag (Cat. No. IFA-H52H9) on HIS1K Biosensor, can bind Human IFNAR1, Fc Tag (Cat. No. IF1-H5253) with an affinity constant of 0.191 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1

Background

Interferon alpha/beta receptor 1 ( IFNAR1) is also known as Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1 (CRF2-1), Type I interferon receptor 1, IFNAR, which belongs to the type II cytokine receptor family. IFNAR1 /IFNAR contains four fibronectin type-III domains. IFNAR1 associates with IFNAR2 to form the type I interferon receptor. IFNAR1 is receptor for interferons alpha and beta. IFNAR1 can transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.

Clinical and Translational Updates

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Recombinant human interferon alfa-2b (Harbin Pharmaceutical Group Bioengineering) Approved Harbin Pharmaceutical Group Holding Co Ltd 里亚美, 利分能 Mainland China Condylomata Acuminata; Varicella Zoster Virus Infection; Hepatitis, Viral, Human; Leukemia, Hairy Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, Non-Hodgkin; Multiple Myeloma Harbin Pharmaceutical Group Holding Co Ltd 1996-01-01 Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Hairy Cell; Varicella Zoster Virus Infection; Multiple Myeloma; Hepatitis, Viral, Human; Lymphoma, Non-Hodgkin; Condylomata Acuminata Details
Recombinant human interferon α2b biosimilar (Harbin High-Tech White Swan Pharmaceutical) Approved Harbin High-Tech Group Baitian'Er Pharmaceutical Co Ltd Fu Li Sheng Leukemia, Hairy Cell; Hepatitis; Multiple Myeloma; Leukemia, Myeloid, Chronic-Phase; Lymphoma, Non-Hodgkin; Condylomata Acuminata; Herpes Zoster Details
Recombinant human interferon α2b biosimilar (Zhejiang Hansheng) Approved Zhejiang Beisheng Pharmaceutical Hansheng Pharmaceutical Co Ltd 莱福隆 Mainland China Virus Diseases; Neoplasms Zhejiang Hansheng Pharmaceutical Co Ltd Of Beisheng Pharma 1999-01-01 Virus Diseases; Neoplasms Details
Interferon beta (Toray/Daiichi Sankyo) DL-8234 Approved Toray Industries Inc Feron Japan Hepatitis C Toray Industries Inc, Daiichi Sankyo Co Ltd 1985-04-01 Medulloblastoma; Glioblastoma; Hepatitis B; Hepatitis C; Astrocytoma; Melanoma Details
Anifrolumab MEDI-546; MDX-1333 Approved Medarex, Medimmune Llc SAPHNELO United States Lupus Erythematosus, Systemic Astrazeneca Ab 2021-07-30 Scleroderma, Systemic; Lupus Nephritis; Lupus Erythematosus, Systemic Details

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