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IFN-alpha/beta R1

Brief Information

Name:Interferon-alpha/beta receptor alpha chain
Target Synonym:IFNBR,IFN-Alpha-REC,Beta-Type Antiviral Protein,IFNAR,Cytokine Receptor Class-II Member 1,Interferon Receptor 1,IFNAR1,Interferon Alpha/Beta Receptor 1,Interferon Alpha And Beta Receptor Subunit 1,Type I Interferon Receptor 1,Interferon (Alpha, Beta And Omega) Receptor 1,Alpha-Type Antiviral Protein,IFN-Alpha/Beta Receptor 1,AVP,Interferon-Beta Receptor 1,IFRC,IFN-R-1,CRF2-1,Cytokine Receptor Family 2 Member 1,Interferon-Alpha/Beta Receptor Alpha Chain
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved

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Part of Bioactivity data

 IFN-alpha/beta R1 SPR

Biotinylated Human IFN-alpha / beta R1 Protein, His,Avitag (Cat. No. IF1-H82E3) captured on Biotin CAP-Series S Sensor Chip can bind Human IFN-alpha 1, Fc Tag (Cat. No. IFA-H5258) with an affinity constant of 0.177 μM as determined in a SPR assay (Biacore 8K) (QC tested).

 IFN-alpha/beta R1 SPR

Mouse IFN-alpha / beta R1, His Tag (Cat. No. IF1-M5225) immobilized on CM5 Chip can bind Mouse IFN-alpha 1, His Tag (Cat. No. IFA-M52H3) with an affinity constant of 2.96 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Synonym Name



Interferon alpha/beta receptor 1 ( IFNAR1) is also known as Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1 (CRF2-1), Type I interferon receptor 1, IFNAR, which belongs to the type II cytokine receptor family. IFNAR1 /IFNAR contains four fibronectin type-III domains. IFNAR1 associates with IFNAR2 to form the type I interferon receptor. IFNAR1 is receptor for interferons alpha and beta. IFNAR1 can transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.

Clinical and Translational Updates

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Interferon beta (Toray/Daiichi Sankyo) DL-8234 Approved Toray Industries Inc Feron Japan Hepatitis C; Astrocytoma; Glioblastoma; Hepatitis B; Medulloblastoma; Melanoma null 1985-04-01 Medulloblastoma; Glioblastoma; Hepatitis B; Hepatitis C; Astrocytoma; Melanoma Details
Recombinant human interferon alfa-2b (Harbin Pharmaceutical Group Bioengineering) Approved Harbin Pharmaceutical Group Holding Co Ltd 里亚美, 利分能 Mainland China Condylomata Acuminata; Varicella Zoster Virus Infection; Leukemia, Hairy Cell; Leukemia, Myelogenous, Chronic; Lymphoma, Non-Hodgkin; Multiple Myeloma; Hepatitis, Viral, Human Harbin Pharmaceutical Group Pharmaceutical Co Ltd 1996-01-01 Leukemia, Myelogenous, Chronic; Leukemia, Hairy Cell; Varicella Zoster Virus Infection; Multiple Myeloma; Hepatitis, Viral, Human; Lymphoma, Non-Hodgkin; Condylomata Acuminata Details
Recombinant human interferon α2b biosimilar (Harbin High-Tech White Swan Pharmaceutical) Approved Harbin High-Tech Group Baitian'Er Pharmaceutical Co Ltd Fu Li Sheng Leukemia, Hairy Cell; Hepatitis; Multiple Myeloma; Leukemia, Myeloid, Chronic-Phase; Lymphoma, Non-Hodgkin; Herpes Zoster; Condylomata Acuminata Details
Anifrolumab MEDI-546; MDX-1333 Approved Medimmune Llc, Medarex SAPHNELO United States Lupus Erythematosus, Systemic Astrazeneca Ab 2021-07-30 Polymyositis; Atherosclerosis; Scleroderma, Systemic; Sjogren's Syndrome; Lupus Erythematosus, Cutaneous; Lupus Nephritis; Lupus Erythematosus, Systemic; Cardiovascular Diseases; Vitiligo Details
Recombinant human interferon α2b biosimilar (Zhejiang Hansheng) Approved Zhejiang Hansheng Pharmaceutical Co Ltd Of Beisheng Pharma 莱福隆 Mainland China Neoplasms; Virus Diseases Zhejiang Hansheng Pharmaceutical Co Ltd Of Beisheng Pharma 1999-01-01 Neoplasms; Virus Diseases Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant human interferon α2b biosimilar (West China Hospital) West China Hospital Of Sichuan University Details

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