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Your Position: Home > IFN-alpha/beta R1

IFN-alpha/beta R1

Brief Information

Name:Interferon-alpha/beta receptor alpha chain
Target Synonym:IFNBR,IFN-Alpha-REC,Beta-Type Antiviral Protein,IFNAR,Cytokine Receptor Class-II Member 1,Interferon Receptor 1,IFNAR1,Interferon Alpha/Beta Receptor 1,Interferon Alpha And Beta Receptor Subunit 1,Type I Interferon Receptor 1,Interferon (Alpha, Beta And Omega) Receptor 1,Alpha-Type Antiviral Protein,IFN-Alpha/Beta Receptor 1,AVP,Interferon-Beta Receptor 1,IFRC,IFN-R-1,CRF2-1,Cytokine Receptor Family 2 Member 1,Interferon-Alpha/Beta Receptor Alpha Chain
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved

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Part of Bioactivity data

IF1-M5225-SPR
Human_FcRn_Heterodimer_Protein_SPR

Mouse IFN-alpha / beta R1, His Tag (Cat. No. IF1-M5225) immobilized on CM5 Chip can bind Mouse IFN-alpha 1, His Tag (Cat. No. IFA-M52H3) with an affinity constant of 2.96 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

IF1-H5225-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IFNAR1, His Tag (Cat. No. IF1-H5225) on NTA Biosensor, can bind Human IFN-alpha 2b (K46R), Fc Tag (Cat. No. IFB-H5253) with an affinity constant of 0.689 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

Synonym Name

IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1

Background

Interferon alpha/beta receptor 1 ( IFNAR1) is also known as Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1 (CRF2-1), Type I interferon receptor 1, IFNAR, which belongs to the type II cytokine receptor family. IFNAR1 /IFNAR contains four fibronectin type-III domains. IFNAR1 associates with IFNAR2 to form the type I interferon receptor. IFNAR1 is receptor for interferons alpha and beta. IFNAR1 can transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.

Clinical and Translational Updates

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Recombinant human interferon α2b biosimilar (Zhejiang Hansheng) Approved Zhejiang Hansheng Pharmaceutical Co Ltd Of Beisheng Pharma 莱福隆 Mainland China Virus Diseases; Neoplasms Zhejiang Hansheng Pharmaceutical Co Ltd Of Beisheng Pharma 1999-01-01 Virus Diseases; Neoplasms Details
Recombinant human interferon alfa-2b (Harbin Pharmaceutical Group Bioengineering) Approved Harbin Pharmaceutical Group Holding Co Ltd 里亚美, 利分能 Mainland China Condylomata Acuminata; Varicella Zoster Virus Infection; Hepatitis, Viral, Human; Leukemia, Hairy Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, Non-Hodgkin; Multiple Myeloma Harbin Pharmaceutical Group Pharmaceutical Co Ltd 1996-01-01 Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Hairy Cell; Varicella Zoster Virus Infection; Multiple Myeloma; Hepatitis, Viral, Human; Lymphoma, Non-Hodgkin; Condylomata Acuminata Details
Recombinant human interferon α2b biosimilar (Harbin High-Tech White Swan Pharmaceutical) Approved Harbin High-Tech Group Baitian'Er Pharmaceutical Co Ltd Fu Li Sheng Leukemia, Hairy Cell; Hepatitis; Multiple Myeloma; Leukemia, Myeloid, Chronic-Phase; Lymphoma, Non-Hodgkin; Condylomata Acuminata; Herpes Zoster Details
Interferon beta (Toray/Daiichi Sankyo) DL-8234 Approved Toray Industries Inc Feron Japan Hepatitis C Toray Industries Inc, Daiichi Sankyo Co Ltd 1985-04-01 Medulloblastoma; Glioblastoma; Hepatitis B; Hepatitis C; Astrocytoma; Melanoma Details
Anifrolumab MEDI-546; MDX-1333 Approved Medimmune Llc, Medarex SAPHNELO Japan Lupus Erythematosus, Systemic Astrazeneca Plc 2021-07-30 Scleroderma, Systemic; Lupus Nephritis; Lupus Erythematosus, Systemic Details

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