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Your Position: Home > IFN-gamma

IFN-gamma

Brief Information

Name:Interferon gamma
Target Synonym:Immune interferon,Interferon gamma,IFNG,IFN-Gamma,IFG,IFI,Interferon-gamma
Number of Launched Drugs:4
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Approved

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Part of Bioactivity data

IFG-H4211-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

The bio-activity of ActiveMax® Human IFN-gamma, Tag Free (Cat. No. IFG-H4211) was determined by dose-dependent inhibition of the proliferation of HT-29 cells. The EC50 for this effect is typically 0.41-0.74 ng/mL (Routinely tested).

IFN-BS138-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Monoclonal Anti-IFNγ antibody, Mouse IgG1 (13E6H6) (Cat. No. IFN-BS138) captured on CM5 chip via anti-mouse antibodies surface can bind ActiveMax® Human IFN-gamma, Tag Free (Cat. No. IFG-H4211) with an affinity constant of 1.28 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

IFN-S120-SPR
Human_FcRn_Heterodimer_Protein_SPR

Monoclonal Anti-IFNγ antibody, Mouse IgG2a (8C5F8) (Cat. No. IFN-S120) captured on CM5 chip via anti-mouse antibodies surface can bind ActiveMax® Human IFN-gamma, Tag Free (Cat. No. IFG-H4211) with an affinity constant of 0.933 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Synonym Name

Interferon-gamma ,Interferon-γ

Background

Interferon-gamma (IFN-γ/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs. IFN-gamma has been used in a wide variety of clinical indications. Interferon-gamma (IFNgamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Cadi-05 Cadi-05 Approved National Institute Of Allergy And Infectious Diseases (Niaid) Immuvac, Leprovac, Mycidac-C India Carcinoma, Non-Small-Cell Lung; Leprosy null 1998-01-01 Leprosy; Carcinoma, Non-Small-Cell Lung Details
Thalidomide NSC-66847; NSC-527179; K-17; VP-02 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Japan Leprosy, Lepromatous Fujimoto Pharmaceutical 1982-01-01 HIV Infections; Spondylitis, Ankylosing; Myelodysplastic Syndromes; Idiopathic Pulmonary Fibrosis; Multiple Myeloma; HIV Wasting Syndrome; Erythema Nodosum; Leprosy, Lepromatous; Carcinoma, Hepatocellular Details
Emapalumab NI-0501 Approved Novimmune Gamifant United States Lymphohistiocytosis, Hemophagocytic Novimmune Sa 2018-11-20 Still's Disease, Adult-Onset; Macrophage Activation Syndrome; Rare Diseases; Arthritis, Juvenile; Immune System Diseases; Lupus Erythematosus, Systemic; Lymphohistiocytosis, Hemophagocytic Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PDS-0101 PDS-0101B; PDS-0101C; PDS-0101; PDS-0101A; PDS-101 Phase 2 Clinical Pds Biotechnology Corporation, Merck Serono Head and Neck Neoplasms; Papillomavirus Infections; Anal intraepithelial neoplasia; Cervical Intraepithelial Neoplasia; Oropharyngeal Neoplasms; Uterine Cervical Neoplasms Details
PP-001 PP-001 Phase 2 Clinical 4sc Ag Keratoconjunctivitis; Uveitis Details
Recombinant human interferon gamma adenovirus injection Phase 1 Clinical Guangzhou Dabo Biological Products Co Ltd Liver Neoplasms; Nasopharyngeal Neoplasms Details
OCH-NCNP1 OCH-NCNP1 Phase 2 Clinical Keio University Multiple Sclerosis; Crohn Disease Details
Tadekinig alfa (AB2 Bio) Phase 3 Clinical Ab2 Bio Macrophage Activation Syndrome; Immune System Diseases Details
Vidofludimus 4SC-101; SC-12267 Phase 2 Clinical 4sc Ag Inflammatory Bowel Diseases; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease Details
SP-002 SP-002; ASN-002; TG-1042 Phase 2 Clinical Lymphoma, B-Cell; Carcinoma, Basal Cell; Skin Neoplasms; Basal Cell Nevus Syndrome Details

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