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IFN-gamma

IFN-gamma Molecule Information

Name:Interferon gamma
Target Synonym:Immune interferon;IFNG;Interferon gamma;IFN-gamma
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:13
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
IFG-H4211 Human ActiveMax® Human IFN-gamma / IFNG Protein, Tag Free
IFG-H4211-structure
IFG-H4211-sds
IFG-H4211-elisa_1

IFN-gamma Molecule Synonym Name

Interferon-gamma ,Interferon-¦Ã

IFN-gamma Molecule Background

Interferon-gamma (IFN-¦Ã/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-¦Ã belongs. IFN-gamma has been used in a wide variety of clinical indications. Interferon-gamma (IFNgamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression.

IFN-gamma References

IFN-gamma Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Cadi-05 Cadi-05 Approved National Institute of Allergy and Infectious Diseases, Cadila Non small cell lung cancer (NSCLC), Leprosy Details
Interferon biosimilar (LG Life Sciences) Approved LG Life Sciences Leukemia Details
Emapalumab NI-0501 Approved NovImmune, SOBI GAMIFANT fda Hemophagocytic lymphohistiocytosis NOVIMMUNE S.A. 2018-11-20 Hemophagocytic lymphohistiocytosis Details
Recombinant interferon gamma (Shanghai Chemo Wanbang Biopharma) Approved Shanghai ChemoWanbang Biopharma Hepatic fibrosis, Rheumatoid arthritis (RA) Details
Thalidomide NSC-527179; NSC-66847; K-17,NSC527179; NSC66847; K17,NSC 527179; NSC 66847; K 17 Approved Celgene THALOMID fda Erythema nodosum leprosum (ENL), Multiple myeloma (MM) CELGENE 1998-07-16 Erythema nodosum leprosum (ENL), Multiple myeloma (MM) Details

IFN-gamma Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
VPM-4001 VPM-4001; VPM-4-001,VPM 4001; VPM 4 001,VPM4001 Phase Ⅱ Memorial Sloan-Kettering Cancer Center, Vakzine Projekt Management Prostate cancer Details
Recombinant human interferon gamma adenovirus injection Phase Ⅰ Guangzhou dabo biological products Nasopharyngeal cancer, Liver cancer Details
LP-0058 LP-0058; LEO-32731,LP0058,LEO32731 Phase Ⅱ Leo Pharma Psoriasis, Atopic dermatitis Details
AMG-811 AMG-811,AMG811 Phase Ⅰ Amgen Systemic lupus erythematosus Details
QR-449 QR-440; QR-443; QR-449 Phase Ⅰ ProPhase Labs Cachexia, Metabolic disorders, Pain Details
AS-1409 AS-1409,AS1409 Phase Ⅰ Antisoma, EMD Lexigen Renal carcinoma, Melanoma Details
Vidofludimus 4SC-101; SC-12267,4SC101,SC12267 Phase Ⅱ 4SC AG Ulcerative colitis, Crohn's disease Details
Interferon gamma (aerosol, IPF/ COPD), Stony Brook University School of Medicine Phase Ⅱ Stony Brook University School of Medicine, NYU Langone Medical Center, Nostrum Pulmonary fibrosis, Chronic obstructive pulmonary disease (COPD) Details
RPI-MN RPI-MN Phase Ⅱ Nutra Pharma, Bio Therapeutics, Nanogene Biotechnology HIV infection Details
Recombinant interferon gamma (Xiamen Amoytop Biotech/BioGeneric Pharma) Phase Not Specified Xiamen Amoytop Biotech, BioGeneric Unspecified Details
Fontolizumab Phase Ⅱ PDL BioPharma, Biogen Idec Autoimmune diseases, Psoriasis, Rheumatoid arthritis (RA), Crohn's disease Details
Delmitide RDP-1258; RDP-58; Allotrap-1258 Phase Ⅱ Genzyme, Procter & Gamble Ulcerative colitis, Crohn's disease Details
Anti-interferon-gamma polyclonal antibody (Advanced Biotherapy) Phase Ⅱ Advanced Biotherapy Alopecia, Uveitis, Keratoplasty rejection, Type 1 diabetes, Psoriasis, Epidermolysis bullosa, Vitiligo, Systemic lupus erythematosus, Multiple sclerosis (MS), Rheumatoid arthritis (RA), Pemphigus vulgaris, Herpes simplex virus (HSV) infection Details

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