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IL-1 alpha

Brief Information

Name:Interleukin-1 alpha
Target Synonym:Interleukin-1 Alpha,IL1A,IL1F1,IL-1 alpha,Interleukin 1 Alpha,Hematopoietin-1,Pro-Interleukin-1-Alpha,Preinterleukin 1 Alpha,IL1-ALPHA,IL-1A,IL1,Interleukin-1alpha
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Approved

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Part of Bioactivity data

 IL-1 alpha SPR

Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) immobilized on CM5 Chip can bind Human IL-1 alpha Protein, premium grade (Cat. No. ILA-H5214) with an affinity constant of 18.8 μM as determined in a SPR assay (Biacore 8K) (QC tested).

 IL-1 alpha ELISA

Immobilized Human IL-1 RI Protein, Fc Tag (Cat. No. ILI-H5253) at 10 μg/mL (100 μL/well) can bind Human IL-1 alpha, His Tag (Cat. No. ILA-H5216) with a linear range of 0.3-2.5 μg/mL (QC tested).

Synonym Name



Interleukin-1 alpha (IL1a) is also known as  IL-1A, IL1, IL1-ALPHA,IL1F1,and is a cytokine of the interleukin-1 family. IL1a possesses a wide spectrum of metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. IL-1α is constitutively produced by epithelial cells. It is found in substantial amounts in normal human epidermis and is distributed in a 1:1 ratio between living epidermal cells and stratum corneum.The constitutive production of large amounts of IL-1α precursor by healthy epidermal keratinocytes interfere with the important role of IL-1α in immune responses, assuming skin as a barrier, which prevents the entry of pathogenic microorganisms into the body. In vitro, IL-1α possesses biological effect on cells in the picomolar to femtomolar range. In vivo, Shortly after an onset of an infection into organism, IL-1α activates a set of immune system response processes.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Rilonacept RGN-303; KPL-914 Approved Regeneron Pharmaceuticals Inc Arcalyst United States Cryopyrin-Associated Periodic Syndromes Kiniksa Pharmaceuticals Ltd 2008-02-27 Pericarditis; Inflammation; Scleroderma, Diffuse; Renal Insufficiency, Chronic; Gout; Urticaria; Cryopyrin-Associated Periodic Syndromes; Hearing Loss, Sensorineural; Genetic Diseases, Inborn; Diabetes Mellitus, Type 1; Arthritis, Juvenile; Deficiency of interleukin-1 receptor antagonist; Scleroderma, Systemic; Muckle-Wells Syndrome (MWS); Anemia; Schnitzler Syndrome; Familial Mediterranean Fever; Still's Disease, Adult-Onset Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Tadekinig alfa (AB2 Bio) Phase 3 Clinical Ab2 Bio Ltd Macrophage Activation Syndrome; Cytokine Release Syndrome; Lymphohistiocytosis, Hemophagocytic Details
Bermekimab T2-18C3; RA-18C3; CV-18C3; CA-18C3; MABP-1; MABp1; JNJ-77474462; MAB-p1 Phase 2 Clinical Xbiotech Inc Acne Vulgaris; Hematologic Neoplasms; Pyoderma Gangrenosum; Digestive System Diseases; Diabetes Mellitus, Type 2; Neoplasms; Scleroderma, Systemic; Psoriasis; Colorectal Neoplasms; Hidradenitis Suppurativa; Eczema; Dermatitis, Atopic Details
lutikizumab ABT-981 Phase 2 Clinical Abbvie Inc Osteoarthritis, Knee; Colitis, Ulcerative; Hidradenitis Suppurativa; Osteoarthritis Details
AC-701 AC-701 Phase 2 Clinical Twi Pharmaceuticals Inc Rosacea; Exanthema Details
Vilamakitug XB-2001 Phase 2 Clinical Xbiotech Inc Pancreatic Neoplasms; Arthritis, Rheumatoid; Rheumatic Diseases Details
CAN-10 CAN-10 Phase 1 Clinical Lund University Foundation Scleroderma, Systemic; Psoriasis; Myocarditis; Plaque psoriasis Details
Hutrukin Phase 1 Clinical Xbiotech Inc Details

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