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IL-10

IL-10 Molecule Information

Name:Interleukin-10
Target Synonym:CSIF;IL10;IL-10;Cytokine synthesis inhibitory factor;Interleukin-10
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase ?

IL-10 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
IL0-M4248 Mouse Mouse IL-10 Protein, His Tag
IL0-M4248-structure
IL0-M4248-sds
IL0-H4248 Human Human IL-10 Protein, His Tag
IL0-H4248-structure
IL0-H4248-sds

IL-10 Molecule Synonym Name

CSIF,IL-10,IL10A,TGIF,B-TCGF,GVHDS,MGC126450,MGC126451,RP11-262N9.1,Interleukin-10

IL-10 Molecule Background

Interleukin-10 (IL-10) is also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. Mature human IL-10 shares 72% - 86% amino acid sequence identity with bovine, canine, equine, feline, mouse, ovine, porcine, and rat IL-10. Whereas human IL-10 is active on mouse cells, mouse IL-10 does not act on human cells. IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-¦Ã, IL-2, IL-3, TNF¦Á and GM-CSF made by cells such as macrophages and regulatory T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production. Knockout studies suggested the function of Interleukin-10 / IL-10 as an essential immunoregulator in the intestinal tract. Patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant interleukin-10, showing the importance of interleukin-10 for counteracting excessive immunity in the human body.

IL-10 References

IL-10 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
HMPL-011 HMPL-011 Phase Ⅰ Hutchison Medipharma Autoimmune diseases Details
PUR-0110 PUR-0110; PCT-233 Phase Ⅱ PurGenesis Technologies Ulcerative colitis Details
LP-0058 LP-0058; LEO-32731,LP0058,LEO32731 Phase Ⅱ Leo Pharma Psoriasis, Atopic dermatitis Details
CC-11006 CC-11006 Phase Ⅰ Celgene Myelodysplastic syndrome (MDS), Inflammation Details
Recombinant interleukin-10 (psoriasis), National Cancer Institute rhIL-10 Phase Ⅱ National Cancer Institute Psoriasis Details
Anti-Human IL10 Therapeutic Antibody SCH-708980,SCH 708980,SCH708980 Phase Ⅱ National Institute of Allergy and Infectious Diseases Visceral leishmaniasis Details
MK-1966 MK-1966,MK 1966,MK1966 Phase Ⅰ Merck Sharp & Dohme, Dynavax hematological malignancies Details
BT-063 BT-063 Phase Ⅱ Biotest Systemic lupus erythematosus Details

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