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IL-10

Brief Information

Name:Interleukin-10
Target Synonym:Interleukin 10,IL-10,IL10,CSIF,Cytokine Synthesis Inhibitory Factor,T-Cell Growth Inhibitory Factor,Interleukin-10,GVHDS,IL10A,TGIF
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
IL0-M4248 Mouse Mouse IL-10 Protein, His Tag
IL0-M4248-structure
IL0-M4248-sds
IL0-H4248 Human Human IL-10 Protein, His Tag
IL0-H4248-structure
IL0-H4248-sds

Part of Bioactivity data

IL0-M4248-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Mouse IL-10, His Tag (Cat. No. IL0-M4248) inhibits LPS-induced secretion of IL-6 by RAW264.7 cells. The EC50 for this effect is 0.27-0.39 ng/mL (Routinely tested).

IL0-H4248-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL-10, His Tag (Cat. No. IL0-H4248) inhibits LPS-induced secretion of IL-6 by RAW264.7 cells. The EC50 for this effect is 0.11-0.24 ng/mL (Routinely tested).

Synonym Name

CSIF,IL-10,IL10A,TGIF,B-TCGF,GVHDS,MGC126450,MGC126451,RP11-262N9.1,Interleukin-10

Background

Interleukin-10 (IL-10) is also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. Mature human IL-10 shares 72% - 86% amino acid sequence identity with bovine, canine, equine, feline, mouse, ovine, porcine, and rat IL-10. Whereas human IL-10 is active on mouse cells, mouse IL-10 does not act on human cells. IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and regulatory T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production. Knockout studies suggested the function of Interleukin-10 / IL-10 as an essential immunoregulator in the intestinal tract. Patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant interleukin-10, showing the importance of interleukin-10 for counteracting excessive immunity in the human body.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Thykamine PUR-0110; PCT-233 Phase 3 Clinical Purgenesis Technologies Dermatitis; Colitis, Ulcerative; Proctocolitis Details
MK-1966 MK-1966 Phase 1 Clinical Merck Sharp & Dohme Corp Hematologic Neoplasms Details
ATX-MS-1467 M-2736; ATX-MS-01; ATX-MS-1467; MSC-2358825A Phase 2 Clinical Apitope Technology Multiple Sclerosis, Relapsing-Remitting; Multiple Sclerosis Details
BT-063 BT-063 Phase 2 Clinical Biotest Lupus Erythematosus, Systemic Details
KLS-2031 KLS-2031 Phase 2 Clinical Kolon Life Science Sciatica; Radiculopathy Details
Recombinant anti-InE monoclonal antibody Phase 1 Clinical Dingfu Biotarget Solid tumours Details
Orismilast LP-0058; LEO-32731 Phase 2 Clinical Leo Pharma Inc Drug-Related Side Effects and Adverse Reactions; Psoriasis; Dermatitis, Atopic Details

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