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IL-1 RII

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Cat. No. Species Product Description Structure Purity Feature
IL2-H4256 Human Human IL-1 RII / CD121b Protein, Fc Tag
IL2-H4256-structure
IL2-H4256-sds
IL2-H4256-elisa_1
IL2-H4256-elisa_2
IL2-H4226 Human Human IL-1 RII / CD121b Protein, His Tag
IL2-H4226-structure
IL2-H4226-sds

Part of Bioactivity data

IL2-H4256-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) captured on CM5 chip via anti-human IgG Fc antibodies surface can bind Human IL-1 beta, Tag Free (Cat. No. ILB-H4110) with an affinity constant of 0.622 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

IL2-H4256-ELISA
Human IL-1 RII, Fc TagHuman IL-1 RII, Fc Tag (Cat. No. IL2-H4256) ELISA bioactivity

Immobilized Human IL-1 beta, Tag Free (Cat. No. ILB-H4110) at 10 μg/mL (100 μL/well) can bind Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) with a linear range of 4-125 ng/mL (QC tested).

Synonym Name

CD121b,IL1RB,IL1R2,CDw121b

Background

Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Clinical and Translational Updates

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