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Brief Information

Name:Interleukin-1 receptor accessory protein
Target Synonym:Interleukin-1 receptor 3,IL-1RAcP,IL-1 receptor accessory protein,IL-1R-3,C3orf13,Interleukin 1 Receptor Accessory Protein,IL1R3,Interleukin-1 Receptor Accessory Protein Beta,IL-1R3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
ILP-H5256 Human Human IL-1 RAcP / IL-1 R3 Protein, Fc Tag
ILP-H5225 Human Human IL-1 RAcP / IL-1 R3 Protein, His Tag

Synonym Name



Interleukin-1 receptor accessory protein (IL1RAP or IL-1RAcP) is also known as Interleukin-1 receptor 3 (IL-1R-3 or IL-1R3), C3orf13, which belongs to the interleukin-1 receptor family. IL1RAP contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RAP is detected in liver, skin, placenta, thymus and lung. IL-1R3 / IL1RAP is coreceptor with IL1R1, associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
GSK3903371 GSK3903371 Clinical Glaxosmithkline Plc Neoplasms Details
Nidanilimab CAN-04 Phase 2 Clinical Lund University Foundation Squamous Cell Carcinoma of Head and Neck; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Melanoma Details

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