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Your Position: Home > IL-33

IL-33

Brief Information

Name:Interleukin-33
Target Synonym:Nuclear Factor For High Endothelial Venules,DVS27-Related Protein,IL1F11,IL33,Interleukin-1 family member 11,IL-1F11,Interleukin 33,Nuclear Factor From High Endothelial Venules,C9orf26,NF-HEV,Chromosome 9 Open Reading Frame 26 (NF-HEV),Interleukin-1 Family, Member 11,NFEHEV,DVS27,IL-33,NFHEV,Interleukin-33,DKFZp586H0523
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

IL3-H52H7-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL-33, His Tag (Cat. No. IL3-H52H7) induces IL-8 secretion in HUVECs. The EC50 for this effect is 193.0-311.8 ng/mL (Routinely tested).

IL3-H82H5-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-1RL1, Fc Tag (Cat. No. IL1-H5250) on Protein A Biosensor, can bind with Biotinylated Human IL-33, His,Avitag (Cat. No. IL3-H82H5) an affinity constant of 1.81 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

IL3-H52H7-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-1RL1, Fc Tag (Cat. No. IL1-H5250) on Protein A Biosensor, can bind with Human IL-33, His Tag (Cat. No. IL3-H52H7) an affinity constant of 1.31 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

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Synonym Name

IL33,DV27,C9ORF26,IL1F11,NFHEV,DKFZp586H0523,DVS27,NFEHEV,RP11-575C20.2

Background

Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Torudokimab LY-3375880 Eli Lilly And Company Details
MT-2990 MT-2990 Phase 2 Clinical Mitsubishi Tanabe Pharma Corp Endometriosis Details
Itepekimab REGN-3500; SAR-440340 Phase 3 Clinical Regeneron Pharmaceuticals Inc, Sanofi Asthma; Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic Details
Etokimab ANB-020 Phase 2 Clinical Anaptysbio Inc Pulmonary Eosinophilia; Asthma; Sinusitis; Peanut Hypersensitivity; Dermatitis, Atopic; Hypersensitivity Details
Tozorakimab MEDI-3506 Phase 3 Clinical Medimmune Diabetic Nephropathies; Asthma; Pulmonary Disease, Chronic Obstructive; Bronchitis, Chronic; Dermatitis, Atopic Details
PF-06817024 PF-06817024 Phase 1 Clinical Pfizer Inc Nose Diseases; Dermatitis, Atopic Details

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