IL-33 Molecule Information
Target Synonym:IL1F11;IL33;IL-33;NF-HEV;NFHEV;Interleukin-1 family member 11;IL-1F11;Nuclear factor from high endothelial venules;C9orf26
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase ?
IL-33 Molecule Synonym Name
IL-33 Molecule Background
Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-¦ÊB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.
IL-33 Related Molecule
IL-33 Clinical Drug Information
|Anti-IL-33 mAb (Regeneron Pharmaceuticals/Sanofi)
||Regeneron Pharmaceutical, Sanofi
||Allergic asthma, Chronic obstructive pulmonary disease (COPD)
||Atopic dermatitis, Hypersensitivity, Rhinosinusitis, Asthma
||Atopic dermatitis, Rhinosinusitis