Name:Interleukin-33 Target Synonym:Nuclear Factor For High Endothelial Venules,DVS27-Related Protein,IL1F11,IL33,Interleukin-1 family member 11,IL-1F11,Interleukin 33,Nuclear Factor From High Endothelial Venules,C9orf26,NF-HEV,Chromosome 9 Open Reading Frame 26 (NF-HEV),Interleukin-1 Famil
Number of Launched Drugs:0 Number of Drugs in Clinical Trials:4 Lastest Research Phase:Phase 3 Clinical
Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.