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IL-33

IL-33 Molecule Information

Name:Interleukin-33
Target Synonym:IL1F11;IL33;IL-33;NF-HEV;NFHEV;Interleukin-1 family member 11;IL-1F11;Nuclear factor from high endothelial venules;C9orf26
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase ?

IL-33 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
IL3-H52H7 Human Human IL-33 Protein, His Tag
IL3-H52H7-structure
IL3-H52H7-sds
IL3-H52H7-elisa_1

IL-33 Molecule Synonym Name

IL33,DV27,C9ORF26,IL1F11,NFHEV,DKFZp586H0523,DVS27,NFEHEV,RP11-575C20.2

IL-33 Molecule Background

Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-¦ÊB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.

IL-33 References

IL-33 Related Molecule

IL-33 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
LY-3375880 LY-3375880 Phase Ⅱ Lilly Atopic dermatitis Details
Anti-IL-33 mAb (Regeneron Pharmaceuticals/Sanofi) REGN-3500; SAR-440340 Phase Ⅱ Regeneron Pharmaceutical, Sanofi Allergic asthma, Chronic obstructive pulmonary disease (COPD) Details
Etokimab ANB-020 Phase Ⅱ AnaptysBio Atopic dermatitis, Hypersensitivity, Rhinosinusitis, Asthma Details
PF-06817024 PF-06817024,PF06817024,PF 06817024 Phase Ⅰ Pfizer Atopic dermatitis, Rhinosinusitis Details

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