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IL-33 Molecule Information

Target Synonym:IL1F11;IL33;IL-33;NF-HEV;NFHEV;Interleukin-1 family member 11;IL-1F11;Nuclear factor from high endothelial venules;C9orf26
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase ?

IL-33 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
IL3-H82H5 Human Biotinylated Human IL-33 Protein, His,Avitag™ (MALS verified)
IL3-M5245 Mouse Mouse IL-33 Protein, His Tag (MALS verified)
IL3-C5245 Cynomolgus Cynomolgus IL-33 Protein, His Tag
IL3-H52H7 Human Human IL-33 Protein, His Tag

IL-33 Part of Bioactivity data

Cynomolgus IL-33, His TagCynomolgus IL-33, His Tag (Cat. No. IL3-C5245) ELISA bioactivity

Immobilized Cynomolgus IL-33, His Tag (Cat. No. IL3-C5245) at 5 μg/mL (100 μL/well) can bind Human IL-1RL1, Fc Tag (Cat. No. IL1-H5250) with a linear range of 2-78 ng/mL (QC tested).

Biotinylated Human IL-33, His,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human IL-33, His,Avitag(Cat. No. IL3-H82H5) was more than 90% and the molecular weight of this protein is around 30-40 kDa verified by SEC-MALS.

Biotinylated Human IL-33, His,AvitagBiotinylated Human IL-33, His,Avitag (Cat. No. IL3-H82H5) ELISA bioactivity

Immobilized Human IL-1RL1, Fc Tag (Cat. No. IL1-H5250) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-33, His,Avitag (Cat. No. IL3-H82H5) with a linear range of 0.01-0.156 μg/mL (QC tested).

IL-33 Customer Reviews

IL-33 Molecule Synonym Name


IL-33 Molecule Background

Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.

IL-33 References

IL-33 Related Molecule

IL-33 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
LY-3375880 LY-3375880 Phase Ⅱ Lilly Atopic dermatitis Details
Anti-IL-33 mAb (Regeneron Pharmaceuticals/Sanofi) REGN-3500; SAR-440340 Phase Ⅱ Regeneron Pharmaceutical, Sanofi Allergic asthma, Chronic obstructive pulmonary disease (COPD) Details
Etokimab ANB-020 Phase Ⅱ AnaptysBio Atopic dermatitis, Hypersensitivity, Rhinosinusitis, Asthma Details
PF-06817024 PF-06817024 Phase Ⅰ Pfizer Atopic dermatitis, Rhinosinusitis Details

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