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Your Position: Home > IL-37

IL-37

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Cat. No. Species Product Description Structure Purity Feature
ILB-H51H5 Human Human IL-37 / IL-1F7 Protein, His Tag
ILB-H51H5-structure
ILB-H51H5-sds
ILB-H5141 Human Human IL-37b / IL-1F7b Protein, His Tag
ILB-H5141-structure
ILB-H5141-sds

Synonym Name

IL1F7,IL37,FIL1Z,IL1H4,IL1RP1

Background

Interleukin-1 family member 7 (IL1F7b) ,a member of the IL-1 family, is aslo known as interleukin-37, interleukin-1 homolog 4 (IL-1H4), interleukin-1 zeta (IL-1 zeta) and interleukin-1-related protein, which can interact with SMAD3 and bind to IL18R1, but not to IL1R1, with lower affinity than IL18. IL1F7b is a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Therefore,IL1F7b can suppress, or reduce, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spare anti-inflammatory cytokines. Furthermore,IL1F7b can also inhibit dendritic cell activation.

Clinical and Translational Updates

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