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Your Position: Home > IL-4

IL-4

Brief Information

Name:Interleukin-4
Target Synonym:MGC79402,B-cell stimulatory factor 1,Lymphocyte stimulatory factor 1,IL4,Interleukin 4,B_cell Stimulatory Factor 1,B Cell Growth Factor 1,Binetrakin,Pitrakinra,BSF-1,IL-4,Interleukin 4 Variant 2,BCGF-1,BCGF1,BSF1,Interleukin-4
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

IL4-H82E0-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Biotinylated Human IL-4, Avitag,His Tag (Cat. No. IL4-H82E0) stimulates the proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 1.19-2.64 ng/mL (Routinely tested).

IL4-H4218-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

ActiveMax® Human IL-4, Tag Free (Cat. No. IL4-H4218) stimulates the proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 0.27-0.49 ng/mL (Routinely tested).

IL4-C5259-ELISA
Cynomolgus IL-4, Fc TagCynomolgus IL-4, Fc Tag (Cat. No. IL4-C5259) ELISA bioactivity

Immobilized Cynomolgus / Rhesus macaque IL-4 R alpha, His Tag (Cat. No. ILR-C52H8) at 5 μg/mL (100 μL/well) can bind Cynomolgus IL-4, Fc Tag (Cat. No. IL4-C5259) with a linear range of 0.1-4 ng/mL (QC tested).

IL4-H52H9-MALS-HPLC
Human  IL-4, His Tag (Cat. No. ) MALS images

The purity of Human IL-4, His Tag (Cat. No. IL4-H52H9) is more than 90% and the molecular weight of this protein is around 18-27 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human  IL-4, His TagHuman  IL-4, His Tag (Cat. No. IL4-H52H9) ELISA bioactivity

Immobilized Human IL-4, His Tag (Cat. No. IL4-H52H9) at 5 μg/mL (100 μL/well) can bind Human IL-4 R alpha, Fc Tag (Cat. No. ILR-H5253) with a linear range of 0.5-16 ng/mL (QC tested).

Synonym Name

IL4,BCGF1,BSF1

Background

Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Dectrekumab/VAK-694 QBX-258 Phase 2 Clinical Novartis Pharma Ag Lymphedema; Asthma Details
OCH-NCNP1 OCH-NCNP1 Phase 2 Clinical Keio University Multiple Sclerosis; Crohn Disease Details
Romilkimab SUB-33159; SAR-156597 Phase 2 Clinical Sanofi Idiopathic Pulmonary Fibrosis; Scleroderma, Systemic Details

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