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IL-4

Brief Information

Name:Interleukin-4
Target Synonym:MGC79402,B-cell stimulatory factor 1,Lymphocyte stimulatory factor 1,IL4,Interleukin 4,B_cell Stimulatory Factor 1,B Cell Growth Factor 1,Binetrakin,Pitrakinra,BSF-1,IL-4,Interleukin 4 Variant 2,BCGF-1,BCGF1,BSF1,Interleukin-4
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
IL4-H82E0 Human Biotinylated Human IL-4 Protein, Avitag™,His Tag
IL4-H82E0-structure
IL4-H82E0-sds
IL4-H82E0-elisa_1
IL4-H4218 Human ActiveMax® Human IL-4 Protein, Tag Free
IL4-H4218-structure
IL4-H4218-sds
IL4-H4218-elisa_1

Part of Bioactivity data

IL4-H82E0-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Biotinylated Human IL-4, Avitag,His Tag (Cat. No. IL4-H82E0) stimulates the proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 1.19-2.64 ng/mL (Routinely tested).

IL4-H4218-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

ActiveMax® Human IL-4, Tag Free (Cat. No. IL4-H4218) stimulates the proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 0.27-0.49 ng/mL (Routinely tested).

IL4-H4218-ELISA
ActiveMax® Human IL-4, Tag FreeActiveMax® Human IL-4, Tag Free (Cat. No. IL4-H4218) ELISA bioactivity

Immobilized ActiveMax® Human IL-4, Tag Free (Cat. No. IL4-H4218) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-4 R alpha, Avitag,His Tag (Cat. No. ILR-H82E9) with a linear range of 2-78 ng/mL (QC tested).

IL4-H82E0-ELISA
Biotinylated Human IL-4, Avitag,His TagBiotinylated Human IL-4, Avitag,His Tag (Cat. No. IL4-H82E0) ELISA bioactivity

Immobilized Human IL-4 R alpha, His Tag (Cat. No. ILR-H5221) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-4, Avitag,His Tag (Cat. No. IL4-H82E0) with a linear range of 1.95-15.6 ng/mL (QC tested).

Synonym Name

IL4,BCGF1,BSF1

Background

Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Dectrekumab/VAK-694 QBX-258 Phase 2 Clinical Novartis Pharma Ag Lymphedema; Asthma Details
OCH-NCNP1 OCH-NCNP1 Phase 2 Clinical Keio University Multiple Sclerosis; Crohn Disease Details
Romilkimab SUB-33159; SAR-156597 Phase 2 Clinical Sanofi Idiopathic Pulmonary Fibrosis; Scleroderma, Systemic Details
DMT-210 DMT-200; DMT-210; DMT-220; SIG-990 Phase 2 Clinical Signum Dermalogix Rosacea; Dermatitis, Atopic Details
LQ-036 LQ-036 Phase 1 Clinical Shanghai Novamab Biopharmaceuticals Co Ltd Asthma Details

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