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Your Position: Home > IL-4

IL-4

Brief Information

Name:Interleukin-4
Target Synonym:MGC79402,B-cell stimulatory factor 1,Lymphocyte stimulatory factor 1,IL4,Interleukin 4,B_cell Stimulatory Factor 1,B Cell Growth Factor 1,Binetrakin,Pitrakinra,BSF-1,IL-4,Interleukin 4 Variant 2,BCGF-1,BCGF1,BSF1,Interleukin-4
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
CRS-B003 Human Human IL-4 ELISA Kit
EP-132 Human IL-4 [Biotinylated] : IL-4Rα Inhibitor Screening ELISA Kit
CEA-C003 Human Human IL-4 ELISA Kit
CRS-A004 Human Human Interleukin-4(IL-4) ELISA Kit
IL4-H52H9 Human Human IL-4 Protein, His Tag (MALS verified)
IL4-H52H9-structure
IL4-H52H9-sds
IL4-C5259 Cynomolgus Cynomolgus IL-4 Protein, Fc Tag (MALS verified)
IL4-C5259-structure
IL4-C5259-sds
IL4-M52H5 Mouse Mouse IL-4 Protein, His Tag
IL4-M52H5-structure
IL4-M52H5-sds
IL4-H82E0 Human Biotinylated Human IL-4 Protein, Avitag™,His Tag (MALS verified)
IL4-H82E0-structure
IL4-H82E0-sds
IL4-H4218 Human Human IL-4 Protein, premium grade
IL4-H4218-structure
IL4-H4218-sds

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Part of Bioactivity data

IL4-H82E0-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Biotinylated Human IL-4, Avitag,His Tag (Cat. No. IL4-H82E0) stimulates the proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 1.19-2.64 ng/mL (Routinely tested).

IL4-H4218-Cell-based assay
 IL-4 CELL

Human IL-4, premium grade (Cat. No. IL4-H4218) situmulates proliferation of TF-1. The EC50 for this effect is 0.602 µg/mL. The specific activity of Human IL-4, premium grade (Cat. No. IL4-H4218) is approximately 1.79×107 IU/mg, which is calibrated against human IL4 WHO International Stand (NIBSC code: 88/656) (QC tested).

IL4-H52H9-ELISA
Human  IL-4, His TagHuman  IL-4, His Tag (Cat. No. IL4-H52H9) ELISA bioactivity

Immobilized Human IL-4, His Tag (Cat. No. IL4-H52H9) at 5 μg/mL (100 μL/well) can bind Human IL-4 R alpha, Fc Tag (Cat. No. ILR-H5253) with a linear range of 0.5-16 ng/mL (QC tested).

IL4-H52H9-MALS-HPLC
Human  IL-4, His Tag (Cat. No. ) MALS images

The purity of Human IL-4, His Tag (Cat. No. IL4-H52H9) is more than 90% and the molecular weight of this protein is around 18-27 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human  IL-4, His TagHuman  IL-4, His Tag (Cat. No. IL4-H52H9) ELISA bioactivity

Immobilized Human IL-4, His Tag (Cat. No. IL4-H52H9) at 5 μg/mL (100 μL/well) can bind Human IL-4 R alpha, Fc Tag (Cat. No. ILR-H5253) with a linear range of 0.5-16 ng/mL (QC tested).

Synonym Name

IL4,BCGF1,BSF1

Background

Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Dectrekumab/VAK-694 QBX-258 Phase 2 Clinical Novartis Pharma Ag Lymphedema; Asthma Details
OCH-NCNP1 OCH-NCNP1 Phase 2 Clinical Keio University Multiple Sclerosis; Crohn Disease Details
DMT-210 DMT-200; DMT-210; DMT-220; SIG-990 Signum Dermalogix Details
AIR-645 AIR-645; ISIS-369645 Ionis Pharmaceuticals Inc Details
Romilkimab SUB-33159; SAR-156597 Sanofi Details
GSK-2434735 GSK-2434735 Glaxosmithkline Plc Details
VAK-694 VAK-694; NVP-VAK-694 Novartis Pharma Ag Details
Berdazimer sodium NVN1000-SB206; MAP3-NONOate - SB-206; SB-019; NVN-1000-SB-206-Novan; SB-206 Novan Details

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