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Brief Information

Target Synonym:MGC79402,B-cell stimulatory factor 1,Lymphocyte stimulatory factor 1,IL4,Interleukin 4,B_cell Stimulatory Factor 1,B Cell Growth Factor 1,Binetrakin,Pitrakinra,BSF-1,IL-4,Interleukin 4 Variant 2,BCGF-1,BCGF1,BSF1,Interleukin-4
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Approved

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Part of Bioactivity data

GMP-L04H26-Cell-based assay

GMP Human IL-4 Protein (Cat. No. GMP-L04H26) stimulates proliferation of TF-1 human erythroleukemic cell line. The specific activity of GMP Human IL-4 Protein is > 1.20×10^7 IU/mg, which is calibrated against human IL-4 WHO International Standard (NIBSC code: 88/656) (QC tested).

IL4-H82E0-Cell-based assay

Biotinylated Human IL-4, Avitag,His Tag (Cat. No. IL4-H82E0) stimulates the proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 1.19-2.64 ng/mL (Routinely tested).

IL-4 [Biotinylated] : IL-4Rα Inhibitor Screening ELISA KitIL-4 [Biotinylated] : IL-4Rα Inhibitor Screening ELISA Kit (Cat. No. EP-132) ELISA bioactivity

Serial dilutions of Human IL-4(Catalog # EP132-C03) (1:1 serial dilution, from 5 μg/mL to 0.01 μg/mL (295.86-0.58 nM)) was added into IL-4 R alpha: IL-4-Biotin binding reactions. The assay was performed according to the above-described protocol. Background was subtracted from data points prior to log transformation and curve fitting (QC tested).

IL-4 MALS images

The purity of Human IL-4 Protein, Fc Tag (Cat. No. IL4-H5253) is more than 90% and the molecular weight of this protein is around 90-110 kDa verified by SEC-MALS.

Customer Reviews

Synonym Name



Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Berdazimer sodium-SB-206 (Novan) NVN-1000-SB-206-Novan; MAP3-NONOate - SB-206; NVN1000-SB206; SB-206; SB-019; NI-MC101 Approved Novan Inc Zelsuvmi, ZELSUVMI, KINSOLUSTM United States Molluscum Contagiosum Lnhc Inc 2024-01-05 Acne Vulgaris; Tinea Pedis; Psoriasis; Molluscum Contagiosum; Condylomata Acuminata; Dermatitis, Atopic Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Berdazimer sodium-SB-204 (Novan) MAP3-NONOate-SB-204; NVN1000-SB204; SB-204 Phase 3 Clinical University Of North Carolina At Chapel Hill Acne Vulgaris Details
Eblasakimab MK-6105; ASLAN-004; CSL-334 Phase 2 Clinical Csl Ltd, Merck Sharp & Dohme Corp Dermatitis, Atopic; Hypersensitivity Details
Dectrekumab/VAK-694 QBX-258 Phase 2 Clinical Novartis Pharma Ag Lymphedema; Asthma Details
OCH-NCNP1 OCH-NCNP1 Phase 2 Clinical Keio University Multiple Sclerosis; Crohn Disease Details
PF-07264660 PF-07264660 Phase 2 Clinical Pfizer Inc Dermatitis, Atopic Details
PF-07275315 PF-07275315 Phase 2 Clinical Pfizer Inc Dermatitis, Atopic Details
AUP1602-C AUP-16; AUP1602-C Phase 2 Clinical Aurealis Diabetic Foot; Ulcer Details
KBL-693 KBL-693 Phase 1 Clinical Kobiolabs Asthma Details

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