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IL-4 Molecule Information

Target Synonym:B-cell stimulatory factor 1;Pitrakinra;Interleukin-4;Binetrakin;BSF-1;Lymphocyte stimulatory factor 1;IL4;IL-4
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:10
Lastest Research Phase:Phase ?

IL-4 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
IL4-H82E0 Human Biotinylated Human IL-4 Protein, Avitag™,His Tag
IL4-H4218 Human ActiveMax® Human IL-4 Protein, Tag Free

IL-4 Molecule Synonym Name


IL-4 Molecule Background

Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.

IL-4 References

IL-4 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Interleukin-4/13 Trap IL-4/IL-13 trap Phase Ⅰ Regeneron Pharmaceutical Hypersensitivity, Asthma Details
GSK-2434735 GSK-2434735,GSK 2434735,GSK2434735 Phase Ⅰ GlaxoSmithKline Asthma Details
AIR-645 AIR-645; ISIS-369645 Phase Ⅱ Ionis, Altair Therapeutics Allergic asthma Details
VAK-694 VAK-694; NVP-VAK-694 Phase Ⅱ Novartis Seasonal allergic rhinitis Details
Pascolizumab SB-240683 Phase Ⅱ GlaxoSmithKline, PDL BioPharma Asthma Details
Binetrakin (Eastman/Immunex) Phase Ⅱ Immunex, Eastman Cancer Details
Dectrekumab/VAK-694 QBX-258 Phase Ⅱ Novartis Secondary lymphedema, Asthma Details
Romilkimab SAR-156597; SUB-33159 Phase Ⅱ Sanofi Idiopathic pulmonary fibrosis (IPF) Details
IL-4R (Aradigm) Phase Ⅱ Aradigm Asthma Details
P-45 P-45; P-45FP Phase Ⅱ IXICO Alopecia Details
OCH-NCNP1 OCH-NCNP1,OCHNCNP1 Phase Ⅱ Keio University, Ajinomoto Multiple sclerosis (MS), Crohn's disease Details

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