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IL-5 R alpha

IL-5 R alpha Molecule Information

Name:Interleukin-5 receptor subunit alpha
Target Synonym:IL5RA,CD125,IL-5RA,IL-5R Subunit Alpha,CDw125,Interleukin-5 Receptor Alpha Chain,HSIL5R3,Interleukin 5 Receptor, Alpha,Interleukin-5 Receptor Subunit Alpha,CD125 Antigen,Interleukin 5 Receptor Subunit Alpha,Interleukin 5 Receptor Type 3,Interleukin-5 Rece
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

IL-5 R alpha Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
ILA-H5259 Human Human IL-5 R alpha / CD125 Protein, Fc Tag
ILA-H5259-structure
ILA-H5259-sds
ILA-H5259-elisa_1
ILA-H52H4 Human Human IL-5 R alpha / CD125 Protein, His Tag
ILA-H52H4-structure
ILA-H52H4-sds

IL-5 R alpha Part of Bioactivity data

ILA-H5259-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-5, His Tag (Cat. No. IL5-H52H3) on NTA Biosensor, can bind Human IL-5 R alpha, Fc Tag (Cat. No. ILA-H5259) with an affinity constant of 4.63 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

ILA-H5259-ELISA
Human IL-5 R alpha, Fc TagHuman IL-5 R alpha, Fc Tag (Cat. No. ILA-H5259) ELISA bioactivity

Immobilized Human IL-5, His Tag (Cat. No. IL5-H52H3) at 5 μg/mL (100 μL/well) can bind Human IL-5 R alpha, Fc Tag (Cat. No. ILA-H5259) with a linear range of 2-39 ng/mL (QC tested).

IL-5 R alpha Molecule Synonym Name

IL5Ra,CD125

IL-5 R alpha Molecule Background

Interleukin-5 receptor subunit alpha (IL5RA) is also known as IL-5 receptor subunit alpha, IL-5R subunit alpha and CD125,which is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and type 5 subfamily.IL5R, a heterodimer of an alpha and a beta subunit, is expressed on eosinophils and basophils. IL5RA / CD125 is the receptor for interleukin-5 (IL5) and the alpha chain can bind to IL5. The WSXWS motif of IL5RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The beta subunit of IL5R is common to the IL3, IL5 and GM-CSF receptors.

IL-5 R alpha References

IL-5 R alpha Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Benralizumab BIW-8405; KHK-4563; MEDI-563; BIW-8405-IL-5R Approved Biowa, Medimmune Llc Fasenra Japan Asthma s:33:"Astrazeneca Pharmaceutical Co Ltd"; 2017-11-14 Hypereosinophilic Syndrome; Nasal Polyps; Chronic Urticaria; Eosinophilic Esophagitis; Pemphigoid, Bullous; Asthma; Sinusitis; Pulmonary Disease, Chronic Obstructive Details

IL-5 R alpha Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CSL-311 CSL-311 Phase 2 Clinical Csl Ltd Asthma Details

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