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Your Position: Home > IL-5 R alpha

IL-5 R alpha

Brief Information

Name:Interleukin-5 receptor subunit alpha
Target Synonym:IL5RA,CD125,IL-5RA,IL-5R Subunit Alpha,CDw125,Interleukin-5 Receptor Alpha Chain,HSIL5R3,Interleukin 5 Receptor, Alpha,Interleukin-5 Receptor Subunit Alpha,CD125 Antigen,Interleukin 5 Receptor Subunit Alpha,Interleukin 5 Receptor Type 3,Interleukin-5 Rece
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
ILA-H5259 Human Human IL-5 R alpha / CD125 Protein, Fc Tag
ILA-H5259-structure
ILA-H5259-sds
ILA-H5259-elisa_1
ILA-H52H4 Human Human IL-5 R alpha / CD125 Protein, His Tag
ILA-H52H4-structure
ILA-H52H4-sds

Part of Bioactivity data

ILA-H5259-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-5, His Tag (Cat. No. IL5-H52H3) on NTA Biosensor, can bind Human IL-5 R alpha, Fc Tag (Cat. No. ILA-H5259) with an affinity constant of 4.63 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

ILA-H5259-ELISA
Human IL-5 R alpha, Fc TagHuman IL-5 R alpha, Fc Tag (Cat. No. ILA-H5259) ELISA bioactivity

Immobilized Human IL-5, His Tag (Cat. No. IL5-H52H3) at 5 μg/mL (100 μL/well) can bind Human IL-5 R alpha, Fc Tag (Cat. No. ILA-H5259) with a linear range of 2-39 ng/mL (QC tested).

Synonym Name

IL5Ra,CD125

Background

Interleukin-5 receptor subunit alpha (IL5RA) is also known as IL-5 receptor subunit alpha, IL-5R subunit alpha and CD125,which is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and type 5 subfamily.IL5R, a heterodimer of an alpha and a beta subunit, is expressed on eosinophils and basophils. IL5RA / CD125 is the receptor for interleukin-5 (IL5) and the alpha chain can bind to IL5. The WSXWS motif of IL5RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The beta subunit of IL5R is common to the IL3, IL5 and GM-CSF receptors.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Benralizumab BIW-8405; KHK-4563; MEDI-563; BIW-8405-IL-5R Approved Biowa, Medimmune Llc Fasenra Japan Asthma Astrazeneca Pharmaceutical Co Ltd 2017-11-14 Hypereosinophilic Syndrome; Nasal Polyps; Chronic Urticaria; Bronchiectasis; Eosinophilic Esophagitis; Asthma; Sinusitis; Pemphigoid, Bullous; Pulmonary Disease, Chronic Obstructive Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CSL-311 CSL-311 Phase 2 Clinical Csl Ltd Asthma Details

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