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IL-6 R alpha

Brief Information

Name:Interleukin-6 receptor alpha subunit
Target Synonym:IL6RA,IL6RQ,IL6Q,Interleukin-6 Receptor alpha Subunit,sIL6R,gp80,IL-6R subunit alpha,Membrane glycoprotein 80,IL6R,Interleukin 6 Receptor,IL-6 Receptor Subunit Alpha,CD126 Antigen,IL-6R 1,IL-6RA,Interleukin-6 Receptor Subunit Alpha,IL-6R-Alpha,IL-6R-1,CD1
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Approved

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Part of Bioactivity data

ILR-H5259-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-6 R alpha, Fc Tag (Cat. No. ILR-H5259) on Protein A Biosensor, can bind ActiveMax® Human IL-6, Tag Free(Cat. No. IL6-H4218) with an affinity constant of 35.9 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

CD6-H82E8-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human IL-6 R alpha, Avitag,His Tag (Cat. No. CD6-H82E8) on SA Biosensor, can bind ActiveMax® Human IL-6, Tag Free(Cat. No. IL6-H4218) with an affinity constant of 73.1 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

IL6R,CD126,IL-6R-1,IL-6RA,IL6RA,IL-6R-alpha,IL6RQ,gp80

Background

Interleukin 6 receptor (IL6R) is also known as CD126 (Cluster of Differentiation 126) , is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL6R is a protein complex consisting of a IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported. IL6R subunit also shared by many other cytokines. The soluble form of IL6R arises from proteolytic cleavage of membrane-bound IL6Rα, and acts agonistically by making the IL6 ligand accessible to the signal transducer gp130. Dysregulated production of IL6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, or osteoporosis, and it has been reported that a humanized anti-IL6R monoclonal antibody is a promising agent applicable to the therapeutic approach for IL6 driven diseases. Interleukin-6 receptor has been shown to interact with Interleukin 6 and Ciliary neurotrophic factor.

Clinical and Translational Updates

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Sarilumab REGN-88; SAR-153191 Approved Sanofi, Regeneron Pharmaceuticals Inc Kevzara Japan Arthritis, Rheumatoid Sanofi 2017-05-22 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Coronavirus Disease 2019 (COVID-19); Arthritis, Juvenile; Coronavirus Infections Details
Satralizumab RG-6168; SA-237 Approved Chugai Pharmaceutical Co Ltd Enspryng, エンスプリング EU Neuromyelitis Optica Roche Registration Gmbh 2020-06-29 Myasthenia Gravis; Neuromyelitis Optica Details
Tocilizumab MRA; rhPM-1; RG-1569; HPM-1; MRA-SC; R-1569; RO-48775533 Approved Chugai Pharmaceutical Co Ltd Actemra/RoActemra, Actemra, RoActemra, 雅美罗 United States systemic sclerosis-associated interstitial lung disease Genentech Inc 2005-04-11 Coronavirus Disease 2019 (COVID-19); Carcinoma, Hepatocellular; Lymphoma; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Colorectal Neoplasms; Lymphoma, Follicular; Multicentric Castleman's Disease (MCD); Takayasu Arteritis; systemic sclerosis-associated interstitial lung disease; Urinary Bladder Neoplasms; Arthritis, Juvenile; Liver Neoplasms; Carcinoma, Transitional Cell; Lymphoma, Large B-Cell, Diffuse; Spondylitis, Ankylosing; Scleroderma, Systemic; Arthritis, Rheumatoid; Polyarticular Juvenile Idiopathic Arthritis; Giant Cell Arteritis; Solid tumours; Biliary Tract Neoplasms; Cytokine Release Syndrome; Lymphoma, B-Cell Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Atexakin alfa r-IL-6; SON-080 Phase 2 Clinical Merck Serono, Weizmann Institute Of Science Peripheral Nervous System Diseases; Diabetic Neuropathies Details
Tocilizumab biosimilar (AryoGen Pharmed) Phase 3 Clinical Aryogen Biopharma Arthritis, Rheumatoid Details
Levilimab BCD-089 Phase 3 Clinical Biocad Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19) Details
Vobarilizumab ALX-0061; ANTI-IL-6R; 20A11-9mer-ALB11; Anti-IL-6R Nanobody Phase 2 Clinical Ablynx Arthritis, Rheumatoid; Lupus Erythematosus, Systemic Details
Tocilizumab biosimilar (Fresenius kabi) MSB-11456 Phase 3 Clinical Merck Serono Arthritis, Rheumatoid; Autoimmune Diseases Details
Recombinant humanized anti-IL-6R monoclonal antibody (Beijing VDJBio) Phase 1 Clinical Beijing Vdjbio Co Ltd Arthritis, Rheumatoid Details
Recombinant humanized anti-IL-6R antibody (Livzon Group) Phase 3 Clinical Livzon Pharmaceutical Group Inc Arthritis, Rheumatoid Details
Olamkicept FE-301; TJ-301; CR-5/18; FE-999301 Phase 2 Clinical Conaris Research Institute Inflammatory Bowel Diseases; Colitis, Ulcerative; Crohn Disease Details
CMAB806 CMAB-806 Phase 3 Clinical Taizhou Maibo Taike Biotechnology Co Ltd Arthritis, Rheumatoid; Arthritis Details
Recombinant humanized anti-IL-6R antibody (Hisun Pharma) HS-628 Phase 3 Clinical Zhejiang Hisun Pharmaceutical Co Ltd Arthritis, Rheumatoid; Arthritis Details
Tocilizumab biosimilar (Bio-Thera Solutions) BAT-1806 Phase 3 Clinical Bio-Thera Solutions Ltd Arthritis, Rheumatoid Details
Tocilizumab Biosimilar (qyuns) QX-003-S Phase 1 Clinical Jiangsu Quanxin Biomedical Co Ltd Arthritis, Rheumatoid Details

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