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gp130 Molecule Information

Name:Interleukin-6 receptor subunit beta
Target Synonym:Oncostatin-M receptor subunit alpha;CD_antigen=CD130;IL-6R-beta;gp130;Interleukin-6 signal transducer;Membrane glycoprotein 130;IL-6R subunit beta;Interleukin-6 receptor subunit beta;CDw130;IL-6 receptor subunit beta;IL-6RB;IL6ST
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:17
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
ILT-M5252 Mouse Mouse gp130 / CD130 / IL-6 R beta Protein, Fc Tag
ILT-M52H1 Mouse Mouse gp130 / CD130 / IL-6 R beta Protein, His Tag

gp130 Molecule Synonym Name


gp130 Molecule Background

Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.

gp130 References

gp130 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Tocilizumab MRA-SC; MRA; rhPM-1; RO-48775533; R-1569; RG-1569; HPM-1,RO48775533; R1569; RG1569; HPM1 Approved Chugai, Genentech Tocilizumab 日本 Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA) 中外制药 2005-04-11 00:00:00.0 Juvenile idiopathic arthritis (JIA), Multicentric Castleman's Disease (MCD), Giant Cell Arteritis, Cytokine Release Syndrome, Systemic juvenile idiopathic arthritis, Rheumatoid arthritis (RA), Takayasu Arterifis, Juvenile rheumatoid arthritis (JRA) Details
Sarilumab REGN-88; SAR-153191,REGN88,SAR153191 Approved Sanofi, Regeneron Pharmaceutical KEVZARA fda Rheumatoid arthritis (RA) SANOFI SYNTHELABO 2017-05-22 Rheumatoid arthritis (RA) Details

gp130 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Tocilizumab biosimilar (AryoGen Pharmed) Phase Ⅲ AryoGen Biopharma Rheumatoid arthritis (RA) Details
CMAB806 CMAB-806 Phase Ⅲ Taizhou Mabtech Rheumatoid arthritis (RA) Details
Atexakin alfa r-IL-6; SON-080 Phase Ⅱ Merck Serono, Weizmann Institute of Science, FirstString Research, RELIEF THERAPEUTICS Holding Diabetic neuropathy, Peripheral  neuropathy Details
Recombinant humanized anti-IL-6R antibody (Livzon Group) Phase Ⅲ Livzon Group Livzon Pharmaceutical Factory Rheumatoid arthritis (RA) Details
Sapelizumab SA-237; RG-6168,SA237 BLA Filing Chugai, Roche Rheumatoid arthritis (RA), Neuromyelitis optica (NMO) Details
Interleukin-6 (Wyeth) BSF-2; ILS-969; SDZ ILS-969,ILS 969,SDZ ILS 969 Phase Ⅲ Pfizer, Novartis Myeloid leukemia, Thrombocytopenia, Solid tumours, Ovarian cancer, Renal carcinoma, Melanoma Details
Tocilizumab biosimilar (Fresenius kabi) MSB-11456 Phase Ⅲ Merck Serono, Fresenius Kabi Rheumatoid arthritis (RA) Details
Interleukin-6 (Yeda) Phase Ⅱ Yeda Pharma, Merck Serono Thrombocytopenia, hematological malignancies, Leukemia, Haematological disorders Details
Olamkicept FE-301; FE-999301; TJ-301; CR-5/18 Phase Ⅱ Conaris Research Institute, Ferring Pharmaceuticals, I-MAB Biopharma Crohn's disease, Inflammatory bowel disease Details
Tocilizumab biosimilar (Bio-Thera Solutions) BAT-1806,BAT1806; BAT 1806 Phase Ⅲ Bio-Thera Solutions Rheumatoid arthritis (RA) Details
Recombinant humanized anti-IL-6R monoclonal antibody (Beijing VDJBio) Phase Ⅰ Beijing VDJBio Rheumatoid arthritis (RA) Details
Interleukin-6 (Ajinomoto) Phase Ⅱ Ajinomoto Thrombocytopenia, Cancer Details
Recombinant humanized anti-IL-6R antibody (Hisun Pharma) HS-628 Phase Ⅲ Hisun Pharm Rheumatoid arthritis (RA) Details
Levilimab BCD-089 Phase Ⅲ Biocad Rheumatoid arthritis (RA) Details
Vobarilizumab ALX-0061; ANTI-IL-6R; Anti-IL-6R Nanobody; 20A11-9mer-ALB11 Phase Ⅱ Ablynx, Abbvie Systemic lupus erythematosus, Rheumatoid arthritis (RA) Details
Pegylated recombinant human interleukin-6 IND Filing Chengdu Institute of Biological Products Unspecified Details
Tocilizumab Biosimilar (qyuns) QX-003-S Phase Ⅰ Jiangsu Qyuns Biotech Rheumatoid arthritis (RA) Details

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