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Brief Information

Name:Interleukin-6 receptor subunit beta
Target Synonym:Interleukin Receptor Beta Chain,IL-6R Subunit Beta,Interleukin-6 Receptor Subunit Beta,Membrane Glycoprotein Gp130,Gp130 Of The Rheumatoid Arthritis Antigenic Peptide-Bearing Soluble Form,CD130 Antigen,SGP130,Interleukin-6 Signal Transducer,IL6ST,Oncostat
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
ILT-M5252 Mouse Mouse gp130 / CD130 / IL-6 R beta Protein, Fc Tag
ILT-M52H1 Mouse Mouse gp130 / CD130 / IL-6 R beta Protein, His Tag

Synonym Name



Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Sarilumab REGN-88; SAR-153191 Approved Sanofi, Regeneron Pharmaceuticals Inc Kevzara Japan Arthritis, Rheumatoid Sanofi 2017-05-22 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Coronavirus Disease 2019 (COVID-19); Arthritis, Juvenile; Coronavirus Infections Details
Satralizumab RG-6168; SA-237 Approved Chugai Pharmaceutical Co Ltd Enspryng, エンスプリング EU Neuromyelitis Optica Roche Registration Gmbh 2020-06-29 Myasthenia Gravis; Neuromyelitis Optica Details
Tocilizumab MRA; rhPM-1; RG-1569; HPM-1; MRA-SC; R-1569; RO-48775533 Approved Chugai Pharmaceutical Co Ltd Actemra/RoActemra, Actemra, RoActemra, 雅美罗 United States systemic sclerosis-associated interstitial lung disease Genentech Inc 2005-04-11 Coronavirus Disease 2019 (COVID-19); Carcinoma, Hepatocellular; Lymphoma; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Colorectal Neoplasms; Lymphoma, Follicular; Multicentric Castleman's Disease (MCD); Takayasu Arteritis; systemic sclerosis-associated interstitial lung disease; Urinary Bladder Neoplasms; Arthritis, Juvenile; Liver Neoplasms; Carcinoma, Transitional Cell; Lymphoma, Large B-Cell, Diffuse; Spondylitis, Ankylosing; Scleroderma, Systemic; Arthritis, Rheumatoid; Polyarticular Juvenile Idiopathic Arthritis; Giant Cell Arteritis; Solid tumours; Biliary Tract Neoplasms; Cytokine Release Syndrome; Lymphoma, B-Cell Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Atexakin alfa r-IL-6; SON-080 Phase 2 Clinical Merck Serono, Weizmann Institute Of Science Peripheral Nervous System Diseases; Diabetic Neuropathies Details
Tocilizumab biosimilar (AryoGen Pharmed) Phase 3 Clinical Aryogen Biopharma Arthritis, Rheumatoid Details
Levilimab BCD-089 Phase 3 Clinical Biocad Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19) Details
Vobarilizumab ALX-0061; ANTI-IL-6R; 20A11-9mer-ALB11; Anti-IL-6R Nanobody Phase 2 Clinical Ablynx Arthritis, Rheumatoid; Lupus Erythematosus, Systemic Details
Tocilizumab biosimilar (Fresenius kabi) MSB-11456 Phase 3 Clinical Merck Serono Arthritis, Rheumatoid; Autoimmune Diseases Details
Recombinant humanized anti-IL-6R monoclonal antibody (Beijing VDJBio) Phase 1 Clinical Beijing Vdjbio Co Ltd Arthritis, Rheumatoid Details
Recombinant humanized anti-IL-6R antibody (Livzon Group) Phase 3 Clinical Livzon Pharmaceutical Group Inc Arthritis, Rheumatoid Details
Olamkicept FE-301; TJ-301; CR-5/18; FE-999301 Phase 2 Clinical Conaris Research Institute Inflammatory Bowel Diseases; Colitis, Ulcerative; Crohn Disease Details
CMAB806 CMAB-806 Phase 3 Clinical Taizhou Maibo Taike Biotechnology Co Ltd Arthritis, Rheumatoid; Arthritis Details
Recombinant humanized anti-IL-6R antibody (Hisun Pharma) HS-628 Phase 3 Clinical Zhejiang Hisun Pharmaceutical Co Ltd Arthritis, Rheumatoid; Arthritis Details
Tocilizumab biosimilar (Bio-Thera Solutions) BAT-1806 Phase 3 Clinical Bio-Thera Solutions Ltd Arthritis, Rheumatoid Details
Tocilizumab Biosimilar (qyuns) QX-003-S Phase 1 Clinical Jiangsu Quanxin Biomedical Co Ltd Arthritis, Rheumatoid Details

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