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Leptin R

Leptin R Molecule Information

Name:Leptin receptor
Target Synonym:LEP-R;Leptin receptor;OBR;CD_antigen=CD295;DB ;OB-R;LEPR;OB receptor;HuB219
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
LER-H5252 Human Human Leptin R / CD295 Protein, Fc Tag
LER-H5252-structure
LER-H5252-sds

Leptin R Molecule Synonym Name

LEPR,CD295,DKFZp686B1731,OBR,Leptin receptor

Leptin R Molecule Background

Leptin receptor (LEPR) is also known as LEP-R, cluster of differentiation 295 (CD295), OB-R and B219, is a single-transmembrane-domain receptor of the gp130 family of cytokine receptors. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this protein have been associated with obesity and pituitary dysfunction. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.

Leptin R References

Leptin R Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Metreleptin AC-164594; KTR-103 Approved Amylin Pharmaceutical, AstraZeneca, Bristol-Myers Squibb, Aegerion, Shionogi Metreleptin 日本 Lipodystrophy 盐野义 2013-03-25 00:00:00.0 Lipodystrophy Details

Leptin R Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
REGN-4461 REGN-4461 Phase Ⅰ Regeneron Pharmaceutical Obesity, Lipodystrophy Details
Metreleptin/Pramlintide Acetate AC-137-164594 Phase Ⅱ Amylin Pharmaceutical, Takeda Obesity Details

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