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LILRB4

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Part of Bioactivity data

LI4-H52H7-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human ANGPTL7, His Tag (Cat. No. AN7-H52H5) immobilized on CM5 Chip can bind Human LILRB4, His Tag (Cat. No. LI4-H52H7) with an affinity constant of 4.67 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

LI4-H82E4-ELISA
Biotinylated Human LILRB4, His,AvitagBiotinylated Human LILRB4, His,Avitag (Cat. No. LI4-H82E4) ELISA bioactivity

Immobilized Biotinylated Human LILRB4, His,Avitag (Cat. No. LI4-H82E4) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-LILRB4 Antibody, Human IgG1 with a linear range of 0.1-4 ng/mL (QC tested).

Synonym Name

LILRB4,ILT3,LIR5,CD85K,HM18

Background

Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Clinical and Translational Updates

Related Molecule

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