MBL Molecule Information
Name：Mannose-binding protein C
Target Synonym：Collectin-1?Mannose-binding lectin?MBL?MBP1?COLEC1 ?MBL2?Mannan-binding protein?Mannose-binding protein C?MBP-C
Number of Launched Drugs：0
Number of Drugs in Clinical Trials：1
Lastest Research Phase：Phase ?
||Human MBL Protein
MBL Molecule Synonym Name
MBL Molecule Background
Mannose-binding lectin (MBL) is also known as mannose-binding protein, mannan-binding protein (MBP), Mannose-binding protein C, Collectin-1 (COLEC1), MBL2, which belongs to the class of collectins in the C-type lectin superfamily. MBL contains one C-type lectin domain and one collagen-like domain. MBL has an oligomeric structure (400-700 kDa), built of subunits that contain three presumably identical peptide chains of about 30 kDa each. MBL is calcium-dependent lectin involved in innate immune defense. MBL binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. MBL binds to late apoptotic cells. MBL may bind DNA.
MBL Clinical Drug Information
|Recombinant human mannose-binding lectin (NatImmune/Enzon)
||NatImmune A/S, Enzon Pharmaceuticals