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Neprilysin

Brief Information

Name:Neprilysin
Target Synonym:EC:3.4.24.11,EC 3.4.24,Atriopeptidase,NEP,SFE,Membrane Metallo-Endopeptidase (Neutral Endopeptidase, Enkephalinase, CALLA, CD10),Membrane Metallo-Endopeptidase Variant 1,Membrane Metallo-Endopeptidase Variant 2,Neprilysin-390,Neprilysin-411,CD10 Antigen,EC 3.4.24.11,CMT2T,SCA43,EPN,MME,Enkephalinase,CALLA,Neutral endopeptidase,Common acute lymphocytic leukemia antigen,Neprilysin,CD10,Membrane Metalloendopeptidase,Neutral Endopeptidase 24.11,Skin fibroblast elastase
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Approved

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By Product Status:
By Product Category:
By Species:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
MME-H521b Human Human Neprilysin / MME / CD10 Protein, Tag Free
MME-H521b-structure
MME-H521b-sds
MME-H526a Human Human Neprilysin / MME / CD10 Protein, Fc Tag
MME-H526a-structure
MME-H526a-sds

Synonym Name

MME,CALLA,CD10,DKFZp686O16152,MGC126681,MGC126707,NEP,SFE,Neprilysin

Background

Cluster of differentiation 10 (CD10) is also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, and common acute lymphoblastic leukemia antigen (CALLA), is a 90-110-kDa type II transmembrane glycoprotein normally expressed by a variety of tissues, including epithelial cells of the prostate, kidney, intestine, endometrium, adrenal glands, and lung. This zinc-dependent metalloprotease enzyme cleaves peptide bonds on the amino side of hydrophobic residues and inactivates a variety of physiologically active secreted peptides. CD20 is thought to be the rate-limiting degrading enzyme of amyloid ¦Â peptide (A¦Â) whose abnormal misfolding and aggregation in neural tissue has been implicated in the development of Alzheimer's disease (AD). CD10 is also identified as the common acute lymphoblastic leukemia antigen (CALLA) present on leukemic cells of pre-B phenotype, and thus serves as the most important biomarker in the diagnosis of human acute lymphocytic leukemia (ALL).

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Racecadotril Tiorfan; Hidrasec Approved Bioprojet Pharma Mainland China Diarrhea Bioprojet Pharma 1993-03-23 Diarrhea Details
Sacubitril/Valsartan Sodium Hydrate LCZ-696 Approved Novartis Pharma Ag Entresto, 诺欣妥 Japan Heart Failure Novartis Pharma Ag 2015-07-07 Essential Hypertension; Arrhythmias, Cardiac; Heart Failure, Systolic; Peripheral Arterial Disease; Kidney Failure, Chronic; Ventricular Dysfunction, Left; Obesity; Laryngeal Neoplasms; Lymphoma; Cardiovascular Diseases; Ventricular Remodeling; Atrial Remodeling; Hepatic Insufficiency; Erectile Dysfunction; Cardiomyopathies; Breast Neoplasms; Medullary thyroid cancer (MTC); Hypertension; Postmyocardial Infarction Syndrome; Heart Diseases; Coronavirus Disease 2019 (COVID-19); Cardiomyopathy, Hypertrophic; Renal Insufficiency; Myositis; Myocardial Infarction; Heart Failure Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Debio-0827 PL-37; Debio-0827 Phase 2 Clinical Pharmaleads Pain Details
Dexecadotril Phase 3 Clinical Bioprojet Pharma Gastrointestinal Diseases Details
QR-12000 QR-12000 Phase 1 Clinical Wuhan Langlai Science And Technology Co Ltd Hypertension Details
Sacubitril AHU-377 Novartis Pharma Ag Details
Sacubitril/Allisartan Isoproxil AHU-377/EXP3174; S-086 Phase 3 Clinical Shenzhen Salubris Pharmaceuticals Co Ltd Heart Failure; Hypertension; Essential Hypertension Details
STR-324 STR-324 Phase 2 Clinical Shanghai Pasteur Institute Of Chinese Academy Of Sciences Acute Pain Details

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