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Neprilysin Molecule Information

Target Synonym:EC:,MME,Enkephalinase,CALLA,Neutral endopeptidase,Common acute lymphocytic leukemia antigen,Neprilysin,CD10,Membrane Metalloendopeptidase,Neutral Endopeptidase 24.11,Atriopeptidase,NEP,SFE,Membrane Metallo-Endopeptidase (Neutral Endopeptidase, En
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
MME-H521b Human Human Neprilysin / MME / CD10 Protein, Tag Free
MME-H526a Human Human Neprilysin / MME / CD10 Protein, Fc Tag

Neprilysin Molecule Synonym Name


Neprilysin Molecule Background

Cluster of differentiation 10 (CD10) is also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, and common acute lymphoblastic leukemia antigen (CALLA), is a 90-110-kDa type II transmembrane glycoprotein normally expressed by a variety of tissues, including epithelial cells of the prostate, kidney, intestine, endometrium, adrenal glands, and lung. This zinc-dependent metalloprotease enzyme cleaves peptide bonds on the amino side of hydrophobic residues and inactivates a variety of physiologically active secreted peptides. CD20 is thought to be the rate-limiting degrading enzyme of amyloid ¦Â peptide (A¦Â) whose abnormal misfolding and aggregation in neural tissue has been implicated in the development of Alzheimer's disease (AD). CD10 is also identified as the common acute lymphoblastic leukemia antigen (CALLA) present on leukemic cells of pre-B phenotype, and thus serves as the most important biomarker in the diagnosis of human acute lymphocytic leukemia (ALL).

Neprilysin References

Neprilysin Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Racecadotril Tiorfan; Hidrasec Approved Bioprojet Pharma Mainland China Diarrhea s:16:"Bioprojet Pharma"; 1993-03-23 Diarrhea, Infantile; Diarrhea Details
Sacubitril/Valsartan Sodium Hydrate LCZ-696 Approved Novartis Pharma Ag 诺欣妥, Entresto Japan Heart Failure s:18:"Novartis Pharma Ag"; 2015-07-07 Erectile Dysfunction; Heart Failure; Renal Insufficiency; Myocardial Infarction; Cardiomyopathy, Hypertrophic; Postmyocardial Infarction Syndrome; Hypertension; Essential Hypertension; Hepatic Insufficiency; Lymphoma; Ventricular Dysfunction, Left; Heart Failure, Systolic Details

Neprilysin Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Dexecadotril Phase 3 Clinical Bioprojet Pharma Gastrointestinal Diseases Details
Sacubitril AHU-377 Phase 2 Clinical Novartis Pharma Ag Heart Failure; Cardiomyopathy, Hypertrophic; Hypertension; Essential Hypertension Details
Debio-0827 PL-37; Debio-0827 Phase 2 Clinical Pharmaleads Pain Details
LHW-090 LHV-527; LHW-090 Phase 2 Clinical Novartis Pharma Ag Hypertension; Renal Insufficiency, Chronic Details
Sacubitril/Allisartan Isoproxil S-086; AHU-377/EXP3174 Phase 2 Clinical Shenzhen Salubris Pharmaceuticals Co Ltd Heart Failure; Hypertension; Essential Hypertension Details
STR-324 STR-324 Phase 2 Clinical Shanghai Pasteur Institute Of Chinese Academy Of Sciences Pain; Acute Pain Details

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