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MMP-1 Molecule Information

Name:Matrix metalloproteinase-1
Target Synonym:MMP-1;27 kDa interstitial collagenase;22 kDa interstitial collagenase;MMP1;Interstitial collagenase;Matrix metalloproteinase-1;Fibroblast collagenase;CLG
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
MM1-H5222 Human Human MMP-1 Protein, His Tag

MMP-1 Molecule Synonym Name


MMP-1 Molecule Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Thrombospondins, intervertebral disc proteins, regulate the effective levels of matrix metalloproteinases (MMPs) 2 and 9, which are key effectors of ECM remodeling. Matrix metalloproteinase-1 (MMP-1) is also known as interstitial collagenase and fibroblast collagenase. MMP

MMP-1 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
FCX-013 FCX-013,FCX013; FCX 013 IND Filing Fibrocell Science Systemic sclerosis Details
CP-471358 CP-471358 Phase Ⅰ Pfizer Solid tumours Details
Rebimastat BMS-275291; D-2163 Phase Ⅲ Celltech, Bristol-Myers Squibb Non small cell lung cancer (NSCLC) Details
BT-1718 BDC-17; BT-1718 Phase Ⅱ Bicycle Therapeutics Solid tumours Details

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