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MMP-1

Brief Information

Name:Matrix metalloproteinase-1
Target Synonym:MMP-1,EC 3.4.24,Interstitial Collagenase,Matrix Metalloprotease 1,CLG,Fibroblast Collagenase,Matrix Metallopeptidase 1,Matrix Metalloproteinase-1,EC:3.4.24.7,Matrix Metallopeptidase 1 (Interstitial Collagenase),EC 3.4.24.7,MMP1,CLGN,Matrix Metalloproteina
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
MM1-H5222 Human Human MMP-1 Protein, His Tag
MM1-H5222-structure
MM1-H5222-sds

Synonym Name

MMP1,CLG,CLGN

Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Thrombospondins, intervertebral disc proteins, regulate the effective levels of matrix metalloproteinases (MMPs) 2 and 9, which are key effectors of ECM remodeling. Matrix metalloproteinase-1 (MMP-1) is also known as interstitial collagenase and fibroblast collagenase. MMP

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
FCX-013 FCX-013; HDF-LV-RTS-MMP1 Phase 2 Clinical Fibrocell Science Scleroderma, Systemic; Scleroderma, Localized Details
BT-1718 BDC-17; BT-1718 Phase 2 Clinical Bicycle Therapeutics Neoplasms Details

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