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Brief Information

Name:Bone morphogenetic protein receptor type-1A
Target Synonym:Bone Morphogenetic Protein Receptor Type 1A,EC 2.7.11,Activin receptor-like kinase 3,Bone morphogenetic protein receptor type-1A,ALK3,BMPR1A,Bone Morphogenetic Protein Receptor, Type IA,Serine/Threonine-Protein Kinase Receptor R5,ACVRLK3,BMPR-1A,SKR5,Activin A Receptor, Type II-Like Kinase 3,CD292 Antigen,EC,10q23del,CD292,BMP type-1A receptor,ALK-3,EC:
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved
ACRO Quality

Synonym Name



The bone morphogenetic protein receptor, type IA is also known as BMPR1A or ALK3 is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 290). The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2[1]. Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis.

Clinical and Translational Updates

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