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BMPR-IB

Brief Information

Name:Bone morphogenetic protein receptor type-1B
Target Synonym:BDA1D,Serine/Threonine Receptor Kinase,Activin Receptor-Like Kinase 6,Bone Morphogenetic Protein Receptor Type 1B,ALK6,BMPR-1B,AMDD,Bone Morphogenetic Protein Receptor Type-1B,BMPR1B,CDw293 Antigen,ALK-6,EC 2.7.11,BDA2,CDw293,EC:2.7.11.30,Bone Morphogenet
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved

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Synonym Name

BMPR1B,ALK6,CDw293

Background

The bone morphogenetic protein receptor, type IB is also known as BMPR1B or ALK6 is a protein which in humans is encoded by the BMPR1B gene. Bone morphogenetic proteins (BMPs) signal through the BMP type I and type II receptors to regulate cellular processes, including embryonic development. The type I BMP receptors activin-like kinase (ALK) 3 and ALK6 share a high degree of homology, yet possess distinct signaling roles. Decreased expression of BMPR-IB correlates with poor prognosis in breast cancer patients and leads to increased cell proliferation of breast cancer cells in vitro, and BMPR-IB mediates an inhibitory effect on breast cancer cells. Researchers found that BMP-2-induced apoptosis was mediated by BMP-RIB in osteoblasts and occurred independently of BMP-2-induced osteoblast differentiation.

Clinical and Translational Updates

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