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Your Position: Home > PLGF

PLGF

Brief Information

Name:Placental Growth Factor
Target Synonym:PGFL,Placental Growth Factor-Like,SHGC-10760,D12S1900,PlGF-2,PIGF,Placenta growth factor,PlGF,PGF,Placental Growth Factor,Placental Growth Factor, Vascular Endothelial Growth Factor-Related Protein
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:10
Lastest Research Phase:Approved

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Part of Bioactivity data

PGF-H5256-ELISA
Human PLGF (19-149), Fc TagHuman PLGF (19-149), Fc Tag (Cat. No. PGF-H5256) ELISA bioactivity

Immobilized Human VEGF R1, His Tag (Cat. No. VE1-H5220) at 2 μg/mL (100 μL/well) can bind Human PLGF (19-149), Fc Tag (Cat. No. PGF-H5256) with a linear range of 0.6-5 ng/mL (QC tested).

PGF-H5255-MALS-HPLC
Human PLGF (19-221), Fc Tag (Cat. No. ) MALS images

The purity of Human PLGF (19-221), Fc Tag (Cat. No. PGF-H5255) was more than 85% and the molecular weight of this protein is around 115-130 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human PLGF (19-221), Fc TagHuman PLGF (19-221), Fc Tag (Cat. No. PGF-H5255) ELISA bioactivity

Immobilized Human VEGF R1, His Tag (Cat. No. VE1-H5220) at 2 μg/mL (100 μL/well) can bind Human PLGF (19-221), Fc Tag (Cat. No. PGF-H5255) with a linear range of 0.3-5 ng/mL (QC tested).

Synonym Name

PGF,PLGF,PlGF,PGFL,SHGC-10760

Background

Placental growth factor (PGF) is also known as vascular endothelial growth factor-related protein, PLGF and PlGF2, is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PGF is actived in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. PlGF2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Ziv-aflibercept AVE-0005; BAY-865321 Approved Sanofi, Regeneron Pharmaceuticals Inc Zaltrap Japan Colorectal Neoplasms Sanofi 2012-08-03 Solid tumours; Ovarian Neoplasms; Lung Diseases; Ascites; Prostatic Neoplasms; Colorectal Neoplasms; Lymphoma; Lung Neoplasms; Neoplasm Metastasis Details
Aflibercept BAY-865321; BAT-86-5321 Approved Regeneron Pharmaceuticals Inc, Bayer Ag Eylea Mainland China Macular Degeneration; Macular Edema Bayer Australia Ltd 2011-11-18 Wet Macular Degeneration; Retinopathy of Prematurity; Diabetic Retinopathy; Diabetes Mellitus; Neoplasm Metastasis; Macular Degeneration; Retinal Vein Occlusion; Retinal Degeneration; Diabetes Complications; Diabetes Mellitus, Type 1; Diabetic macular oedema; Prostatic Neoplasms; Retinal Diseases; Myopia, Degenerative; Neoplasms; Glaucoma, Neovascular; Diabetes Mellitus, Type 2; Macular Edema Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Aflibercept biosimilar (CinnaGen)(阿柏西普生物类似药(CinnaGen)) Phase 3 Clinical Cinnagen Macular Degeneration Details
Aflibercept biosimilar (Amgen) Phase 2 Clinical Amgen Inc Macular Degeneration Details
Aflibercept biosimilar (Samsung Bioepis) SB-15 Phase 3 Clinical Samsung Bioepis Macular Degeneration Details
Aflibercept biosimilar (Momenta/Mylan) M-710; MYL-1701P Phase 3 Clinical Mylan, Momenta Diabetic macular oedema Details
Aflibercept/Nesvacumab REGN 910-3 Phase 2 Clinical Regeneron Pharmaceuticals Inc Diabetic macular oedema; Macular Degeneration Details
Aflibercept Biosimilar (Boan Biopharma/Luye Pharma) LY-09004 Phase 3 Clinical Shandong Boan Biotechnology Co Ltd, Luye Pharma Group Ltd Diabetic macular oedema; Macular Degeneration Details
Aflibercept biosimilar (Mabwell) 9MW0813 Phase 1 Clinical Diabetic macular oedema Details
Aflibercept biosimilar (Qilu Pharmaceutical) QL-1207 Phase 3 Clinical Qilu Pharmaceutical Co Ltd Diabetic macular oedema; Macular Degeneration Details
Ziv-aflibercept biosimiliar (Boan Biopharma) LY-01012 Phase 3 Clinical Shandong Boan Biotechnology Co Ltd Wet Macular Degeneration; Colorectal Neoplasms; Macular Degeneration Details
Aflibercept biosimilar (Sam Chun Dang Pharm) SCD-411 Phase 3 Clinical Sam Chun Dang Pharm Co Ltd Macular Degeneration Details
Anti-placental growth factor monoclonal antibody αPlGF; R-7334; TB-403; RG-7334; THR-317; RO-5323441 Phase 2 Clinical Thrombogenics, Bioinvent International Retinal Telangiectasis; Medulloblastoma; Solid tumours; Ovarian Neoplasms; Macular Edema; Glioblastoma; Colorectal Neoplasms; Carcinoma, Hepatocellular; Diabetic Retinopathy; Macular Degeneration; Diabetes Mellitus Details
Aflibercept Biosimilar (Clover Biopharmaceuticals) SCB-420 Phase 1 Clinical Sichuan Sanyecao Bio-Pharmaceutical Co Ltd Diabetic macular oedema; Macular Degeneration Details
CT-P42 CT-P42 Phase 3 Clinical Celltrion Diabetic macular oedema Details
FYB-203 FYB-203 Phase 3 Clinical Formycon Macular Degeneration Details

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