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Your Position: Home > PLGF

PLGF

PLGF Molecule Information

Name:Placental Growth Factor
Target Synonym:PLGF;PGF;PlGF;PGFL ;Placenta growth factor

Number of Launched Drugs:2
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Approved

PLGF Part of Bioactivity data

PGF-R52H0-ELISA

Immobilized Rhesus macaque VEGF R1, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. VE1-R5257) at 5 μg/mL (100 μL/well) can bind Rhesus macaque PLGF, His Tag (Cat. No. PGF-R52H0) with a linear range of 2-40 ng/mL (QC tested).

Protocol

PGF-M52H0-ELISA

Immobilized Mouse VEGF R1, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. VE1-M5256) at 2 μg/mL (100 μL/well) can bind Mouse PLGF, His Tag (Cat. No. PGF-M52H0) with a linear range of 0.2-4 ng/mL (QC tested).

Protocol

PLGF Protein Product ListCompare or Buy

Product> Filter Results

Cat. No.	Species	Product Description
PGF-M52H0	Mouse	Mouse PLGF / PGF Protein, His Tag
PGF-R52H0	Rhesus macaque	Rhesus macaque PLGF / PGF Protein, His Tag
PGF-H5229	Human	Human PLGF / PGF Protein, His Tag

PLGF Molecule Synonym Name

PGF,PLGF,PlGF2,PlGF,PGFL,SHGC-10760

PLGF Molecule Background

Placental growth factor (PGF) is also known as vascular endothelial growth factor-related protein, PLGF and PlGF2, is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PGF is actived in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. PlGF2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.

PLGF References

PLGF Public Drug Information

Name	Research Code	Research Phase	Company	First Brand Name	First Approved Country	First Indication	First Approved Company	First Approved Date	Indications	Clinical Trials
Aflibercept	BAY-865321; BAT-86-5321	Approved	Regeneron Pharmaceutical, Bayer, Santen	EYLEA	fda	Macular edema, Macular degeneration	REGENERON PHARMACEUTICALS	2011-11-18	Macular edema, Macular degeneration	Details
Ziv-aflibercept	AVE-0005; BAY-865321	Approved	Regeneron Pharmaceutical, Sanofi, Yakult	ZALTRAP	fda	Metastatic colorectal cancer (CRC)	SANOFI AVENTIS US	2012-08-03	Colorectal cancer, Metastatic colorectal cancer (CRC)	Details

PLGF Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
Ziv-aflibercept biosimiliar (Boan Biopharma)	LY-01012	Phase Ⅰ	Shandong Boan Biotechnology, Luye Pharma	Metastatic colorectal cancer (CRC)	Details
Aflibercept biosimilar (Momenta/Mylan)	M-710; MYL-1701P	Phase Ⅲ	Momenta, Mylan	Diabetic macular edema	Details
Aflibercept biosimilar (CinnaGen)(阿柏西普生物类似药（CinnaGen）)		Phase Ⅲ	CinnaGen	Wet age-related macular degeneration	Details
Aflibercept biosimilar (Qilu Pharmaceutical)	QL-1207	Phase Ⅲ	Qilu Pharmaceutical	Diabetic macular edema, Wet age-related macular degeneration	Details
Aflibercept Biosimilar (Boan Biopharma/Luye）	LY-09004	Phase Ⅰ	Shandong Boan Biotechnology, Luye Pharma	Diabetic macular edema, Senile Macular Degeneration	Details
Aflibercept/Rinucumab	REGN-2176-3	Phase Ⅱ	Bayer, Regeneron Pharmaceutical	Wet age-related macular degeneration	Details
Aflibercept biosimilar (Amgen)		Phase Ⅱ	Amgen	Wet age-related macular degeneration	Details
Aflibercept/Nesvacumab	REGN 910-3	Phase Ⅱ	Regeneron Pharmaceutical, Bayer	Diabetic macular edema, Wet age-related macular degeneration	Details
Anti-placental growth factor monoclonal antibody	R-7334; RG-7334; RO-5323441; TB-403; THR-317; αPlGF	Phase Ⅱ	BioInvent International, ThromboGenics, Roche, Oncurious	Age-related macular degeneration (AMD), Medulloblastoma	Details