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PLGF

PLGF Molecule Information

Name:Placental Growth Factor
Target Synonym:PLGF;PGF;PlGF;PGFL ;Placenta growth factor
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Approved

PLGF Protein Product ListCompare or Buy

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By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
PGF-M52H0 Mouse Mouse PLGF / PGF Protein, His Tag
PGF-M52H0-structure
PGF-M52H0-sds
PGF-M52H0-elisa_1
PGF-R52H0 Rhesus macaque Rhesus macaque PLGF / PGF Protein, His Tag
PGF-R52H0-structure
PGF-R52H0-sds
PGF-R52H0-elisa_1
PGF-H5229 Human Human PLGF / PGF Protein, His Tag
PGF-H5229-structure
PGF-H5229-sds
PGF-H5229-elisa_1

PLGF Molecule Synonym Name

PGF,PLGF,PlGF2,PlGF,PGFL,SHGC-10760

PLGF Molecule Background

Placental growth factor (PGF) is also known as vascular endothelial growth factor-related protein, PLGF and PlGF2, is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PGF is actived in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. PlGF2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.

PLGF References

PLGF Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Aflibercept BAY-865321; BAT-86-5321 Approved Regeneron Pharmaceutical, Bayer, Santen EYLEA fda Macular edema, Macular degeneration REGENERON PHARMACEUTICALS 2011-11-18 Macular edema, Macular degeneration Details
Ziv-aflibercept AVE-0005; BAY-865321 Approved Regeneron Pharmaceutical, Sanofi, Yakult ZALTRAP fda Metastatic colorectal cancer (CRC) SANOFI AVENTIS US 2012-08-03 Colorectal cancer, Metastatic colorectal cancer (CRC) Details

PLGF Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Aflibercept biosimilar (Momenta/Mylan) M-710; MYL-1701P Phase Ⅲ Momenta, Mylan Diabetic macular edema Details
Aflibercept biosimilar (Qilu Pharmaceutical) QL-1207 Phase Ⅲ Qilu Pharmaceutical Diabetic macular edema, Wet age-related macular degeneration Details
Aflibercept Biosimilar (Boan Biopharma/Luye) LY-09004 Phase Ⅰ Shandong Boan Biotechnology, Luye Pharma Diabetic macular edema, Senile Macular Degeneration Details
Aflibercept/Rinucumab REGN-2176-3 Phase Ⅱ Bayer, Regeneron Pharmaceutical Wet age-related macular degeneration Details
Aflibercept/Nesvacumab REGN 910-3 Phase Ⅱ Regeneron Pharmaceutical, Bayer Diabetic macular edema, Wet age-related macular degeneration Details
Anti-placental growth factor monoclonal antibody R-7334; RG-7334; RO-5323441; TB-403; THR-317; αPlGF Phase Ⅱ BioInvent International, ThromboGenics, Roche, Oncurious Age-related macular degeneration (AMD), Medulloblastoma Details

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