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PLGF

PLGF Molecule Information

Name:Placental Growth Factor
Target Synonym:PLGF;PGF;PlGF;PGFL ;Placenta growth factor
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Approved

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PLGF Part of Bioactivity data

PGF-H5256-ELISA
Human PLGF (19-149), Fc TagHuman PLGF (19-149), Fc Tag (Cat. No. PGF-H5256) ELISA bioactivity

Immobilized Human VEGF R1, His Tag (Cat. No. VE1-H5220) at 2 μg/mL (100 μL/well) can bind Human PLGF (19-149), Fc Tag (Cat. No. PGF-H5256) with a linear range of 0.6-5 ng/mL (QC tested).

PGF-H5255-MALS-HPLC
Human PLGF (19-221), Fc Tag (Cat. No. ) MALS images

The purity of Human PLGF (19-221), Fc Tag (Cat. No. PGF-H5255) was more than 85% and the molecular weight of this protein is around 115-130 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human PLGF (19-221), Fc TagHuman PLGF (19-221), Fc Tag (Cat. No. PGF-H5255) ELISA bioactivity

Immobilized Human VEGF R1, His Tag (Cat. No. VE1-H5220) at 2 μg/mL (100 μL/well) can bind Human PLGF (19-221), Fc Tag (Cat. No. PGF-H5255) with a linear range of 0.3-5 ng/mL (QC tested).

PLGF Molecule Synonym Name

PGF,PLGF,PlGF,PGFL,SHGC-10760

PLGF Molecule Background

Placental growth factor (PGF) is also known as vascular endothelial growth factor-related protein, PLGF and PlGF2, is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PGF is actived in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. PlGF2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.

PLGF References

PLGF Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Aflibercept BAY-865321; BAT-86-5321 Approved Regeneron Pharmaceutical, Bayer, Santen EYLEA fda Macular edema, Macular degeneration REGENERON PHARMACEUTICALS 2011-11-18 Macular edema, Macular degeneration Details
Ziv-aflibercept AVE-0005; BAY-865321 Approved Regeneron Pharmaceutical, Sanofi, Yakult ZALTRAP fda Metastatic colorectal cancer (CRC) SANOFI AVENTIS US 2012-08-03 Colorectal cancer, Metastatic colorectal cancer (CRC) Details

PLGF Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ziv-aflibercept biosimiliar (Boan Biopharma) LY-01012 Phase Ⅰ Shandong Boan Biotechnology, Luye Pharma Metastatic colorectal cancer (CRC) Details
Aflibercept biosimilar (Momenta/Mylan) M-710; MYL-1701P Phase Ⅲ Momenta, Mylan Diabetic macular edema Details
Aflibercept biosimilar (Samsung Bioepis) SB-15 Phase Ⅲ Samsung Bioepis Wet age-related macular degeneration Details
Aflibercept biosimilar (CinnaGen)(阿柏西普生物类似药(CinnaGen)) Phase Ⅲ CinnaGen Wet age-related macular degeneration Details
Aflibercept biosimilar (Qilu Pharmaceutical) QL-1207 Phase Ⅲ Qilu Pharmaceutical Diabetic macular edema, Wet age-related macular degeneration Details
Aflibercept Biosimilar (Boan Biopharma/Luye) LY-09004 Phase Ⅰ Shandong Boan Biotechnology, Luye Pharma Diabetic macular edema, Senile Macular Degeneration Details
Aflibercept/Rinucumab REGN-2176-3 Phase Ⅱ Bayer, Regeneron Pharmaceutical Wet age-related macular degeneration Details
Aflibercept biosimilar (Amgen) Phase Ⅱ Amgen Wet age-related macular degeneration Details
Aflibercept/Nesvacumab REGN 910-3 Phase Ⅱ Regeneron Pharmaceutical, Bayer Diabetic macular edema, Wet age-related macular degeneration Details
Anti-placental growth factor monoclonal antibody R-7334; RG-7334; RO-5323441; TB-403; THR-317; αPlGF Phase Ⅱ BioInvent International, ThromboGenics, Roche, Oncurious Age-related macular degeneration (AMD), Medulloblastoma Details

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