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PH20

PH20 Product List

Cat. No. Species Product Description Structure Purity Feature
PH0-H5225 Human Human PH20 / SPAM1 Protein
PH0-H5225-structure
PH0-H5225-sds

PH20 Molecule Synonym Name

SPAM1,PH-20,HYAL3,HYA1,HYAL1,HYAL5,SPAG15

PH20 Molecule Background

Hyaluronidase PH-20 is also known as Sperm adhesion molecule 1 (SPAM1) and Sperm surface protein PH-20, which belongs to the glycosyl hydrolase 56 family, SPAM1 / PH-20 is expressed in testis. SPAM-1 / PH20 random hydrolysis of (1->4)-linkages between N ¨C acetyl ¨C beta ¨C D ¨C glucosamine and D-glucuronate residues in hyaluronate. SPAM-1 / PH20 involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. SPAM1 aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.

PH20 References

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