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PSGL-1 Molecule Information

Name:P-selectin glycoprotein ligand-1
Target Synonym:P-selectin glycoprotein ligand 1,PSGL-1,SELPLG,Selectin P Ligand,Cutaneous Lymphocyte-Associated Associated Antigen,CD162 Antigen,CD162,PSGL1,CLA
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
PS1-H82E4 Human Biotinylated Human PSGL-1 / CD162 Protein, His,Avitag™
PS1-H52H9 Human Human PSGL-1 / CD162 Protein, His Tag

PSGL-1 Molecule Synonym Name

PSGL1,CD162,SELPLG,Selectin P ligand

PSGL-1 Molecule Background

P-selectin glycoprotein ligand 1 (PSGL-1) is also known as Selectin P ligand (SELPLG), CD antigen CD162. PSGL-1 is disulfide-linked homodimer which is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 / SELPLG  interacts with P-, E- and L-selectins, through their lectin/EGF domains, is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan modification but there is a differing dependence for tyrosine sulfations. Dimerization appears not to be required for P-selectin/SELP binding. PSGL-1 can interact with SNX20, MSN and SYK. PSGL-1 / SELPLG mediate the activation of SYK by SELPLG.

PSGL-1 References

PSGL-1 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Neihulizumab AbGn-168; AbGn-168H Phase 2 Clinical Abgenomics Diabetes Mellitus, Type 1; Graft vs Host Disease; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative Details
SelK-2 SelK-2 Phase 2 Clinical Selexys Venous Thromboembolism; Asthma; Pulmonary Disease, Chronic Obstructive; Crohn Disease Details

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