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PSGL-1

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Cat. No. Species Product Description Structure Purity Feature
PS1-H52H9 Human Human PSGL-1 / CD162 Protein, His Tag
PS1-H52H9-structure
PS1-H52H9-sds

PSGL-1 Molecule Synonym Name

PSGL1,CD162,SELPLG,Selectin P ligand

PSGL-1 Molecule Background

P-selectin glycoprotein ligand 1 (PSGL-1) is also known as Selectin P ligand (SELPLG), CD antigen CD162. PSGL-1 is disulfide-linked homodimer which is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 / SELPLG  interacts with P-, E- and L-selectins, through their lectin/EGF domains, is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan modification but there is a differing dependence for tyrosine sulfations. Dimerization appears not to be required for P-selectin/SELP binding. PSGL-1 can interact with SNX20, MSN and SYK. PSGL-1 / SELPLG mediate the activation of SYK by SELPLG.

PSGL-1 References

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