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PSGL-1

Brief Information

Name:P-selectin glycoprotein ligand-1
Target Synonym:P-selectin glycoprotein ligand 1,PSGL-1,SELPLG,Selectin P Ligand,Cutaneous Lymphocyte-Associated Associated Antigen,CD162 Antigen,CD162,PSGL1,CLA
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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By Product Category:
By Species:
Cat. No. Species Product Description Structure Purity Feature
PS1-H82E4 Human Biotinylated Human PSGL-1 / CD162 Protein, His,Avitag™
PS1-H82E4-structure
PS1-H82E4-sds
PS1-H52H9 Human Human PSGL-1 / CD162 Protein, His Tag
PS1-H52H9-structure
PS1-H52H9-sds
PS1-H52H9-elisa_2

Part of Bioactivity data

PS1-H52H9-BLI
Human_FcRn_Heterodimer_Protein_SPR

Human PSGL-1, His Tag (Cat. No. PS1-H52H9) immobilized on CM5 Chip can bind Human B7-H5, Fc Tag (Cat. No. B75-H5259) with an affinity constant of 0.213 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name

PSGL1,CD162,SELPLG,Selectin P ligand

Background

P-selectin glycoprotein ligand 1 (PSGL-1) is also known as Selectin P ligand (SELPLG), CD antigen CD162. PSGL-1 is disulfide-linked homodimer which is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 / SELPLG  interacts with P-, E- and L-selectins, through their lectin/EGF domains, is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan modification but there is a differing dependence for tyrosine sulfations. Dimerization appears not to be required for P-selectin/SELP binding. PSGL-1 can interact with SNX20, MSN and SYK. PSGL-1 / SELPLG mediate the activation of SYK by SELPLG.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SelK-2 SelK-2 Phase 2 Clinical Selexys Venous Thromboembolism; Asthma; Pulmonary Disease, Chronic Obstructive; Crohn Disease Details
Neihulizumab AbGn-168; AbGn-168H Phase 2 Clinical Abgenomics Diabetes Mellitus, Type 1; Graft vs Host Disease; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative Details

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