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PTH1R

PTH1R Molecule Information

Name:Parathyroid hormone receptor
Target Synonym:PTH/PTHrP type I receptor;PTH/PTHr receptor;Parathyroid hormone/parathyroid hormone-related peptide receptor;PTH1R;PTHR ;PTHR1;Parathyroid hormone 1 receptor;PTH1 receptor
Number of Launched Drugs:14
Number of Drugs in Clinical Trials:44
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
PTR-H5222 Human Human PTH1R / PTHR1 Protein, His Tag
PTR-H5222-structure
PTR-H5222-sds

PTH1R Molecule Synonym Name

PTH1R,PTHR,PTHR1

PTH1R Molecule Background

Parathyroid hormone/parathyroid hormone-related peptide receptor is also known as Parathyroid hormone 1 receptor (PTH1R), PTHR1, PTH/PTHrP type I receptor (PTH/PTHr receptor), which belongs to the G-protein coupled receptor 2 family. PTH1R / PTHR1 is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

PTH1R References

PTH1R Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Teriparatide biosimilar (Intas Pharmaceuticals) rhPTH (1-34) (Intas Pharmaceuticals) Approved Intas Biopharmaceuticals Osteoporosis Details
Teriparatide biosimilar (STADA Arzneimittel AG) rhPTH (1-34) (STADA Arzneimittel AG) Approved STADA Arzneimittel teriparatide ema STADA Arzneimittel AG 2017-01-11 Osteoporosis Details
Teriparatide biosimilar (Virchow/Sun) rhPTH (1-34) (Virchow/Sun) Approved Virchow Group, Sun Pharmaceutical Osteoporosis Details
Teriparatide biosimilar (Gedeon Richter) rhPTH (1-34) (Gedeon Richter) Approved Gedeon Richter teriparatide ema Gedeon Richter Plc. 2017-01-04 Osteoporosis Details
Teriparatide biosimilar (USV) Approved USV Osteoporosis Details
Teriparatide biosimilar (Pfenex) rhPTH (1-34) (Pfenex); PF-708 Approved Pfenex, NT Pharma, Alvogen BONSITY fda PFENEX INC 2019-10-04 Osteoporosis Details
Teriparatide biosimilar (Zydus Cadila) rhPTH (1-34) (Zydus Cadila) Approved Zydus cadila Osteoporosis Details
Teriparatide acetate AK-159; MN-10-T; hPTH (1-34) acet. H2O Approved USV, Ipsen, Asahi Kasei, Sanofi, Dong-A Pharmaceutical Hypocalcaemia, Osteoporosis Details
Teriparatide hPTH-1-34; LY 333334; MN-10T Approved Lilly FORTEO fda Osteoporosis LILLY 2002-11-26 Osteoporosis Details
Teriparatide (Amega Biotech) rhPTH (1-34) (Amega Biotech) Approved Amega Biotech Osteoporosis Details
Abaloparatide ITM-058; BIM-44058; BA-058; BA-058-SC; BA-058-TD,BA058,BIM44058,ITM058 Approved Ipsen, Radius Health TYMLOS fda Postmenopausal osteoporosis RADIUS HEALTH INC 2017-04-28 Postmenopausal osteoporosis Details
Teriparatide biosimilar (Biosidus) rhPTH (1-34) (Biosidus) Approved Biosidus Osteoporosis Details
Teriparatide biosimilar (CinnaGen) rhPTH (1-34) (CinnaGen) Approved CinnaGen Osteoporosis Details
Parathyroid hormone (Shire) 423562; ALX-111; NPSP-795; NPSP-558; PTH (1-84); PTH 1-84; rhPTH (1-84); rhPTH-1-84; SB-423562; SHP-635; SHP-634 Approved Shire parathyroid hormone (rDNA) ema

Treatment of osteoporosis in postmenopausal women at high risk of fractures (see section 5.1).

A significant reduction in the incidence of vertebral, but not hip fractures has been demonstrated.

NPS Pharma Holdings Limited 2006-04-24 Hypoparathyroidism, Osteoporosis Details

PTH1R Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ostabolin topical (Zelos) Phase Ⅱ Zelos Therapeutics Psoriasis Details
Parathyroid hormone 7-34 (IGI) PTH(7-34) Preclinical Teligent Alopecia Details
AJT-240 AJT-240; SK-1403 Phase Ⅲ EA Pharma, JW pharmaceutical, Sanwa Kagaku Kenkyusho, Tasly Pharm Hyperparathyroidism Details
ZYPH-0907 ZYPH-0907 Phase Ⅰ Zydus cadila Osteoporosis Details
Parathyroid hormone (1-34) gel (TG Therapeutics) Phase Ⅰ TG Therapeutics Psoriasis Details
Teriparatide biosimilar (Stelis) SBL-001,SBL001,SBL 001 Phase Ⅰ Stelis Biopharma Osteoporosis Details
Teriparatide liposomal cream (Manhattan Pharmaceuticals) Phase Ⅱ Boston University, TG Therapeutics Psoriasis Details
BIM-44002 BIM-44002 Phase Ⅱ Ipsen Hypercalcemia Details
Recombinant human parathyroid hormone (Green Cross) Phase Ⅱ Green Cross Osteoporosis Details
Teriparatide biosimilar (Shanghai CAS Shenglongda Biotech) Phase Ⅲ Shanghai Zhongke Shenglongda Biotechnology Postmenopausal osteoporosis Details
Recombinant parathyroid hormone (Beijing SL Pharmaceutical) Phase Ⅱ Beijing ShuangLu Pharmaceutical Osteoporosis Details
Teriparatide biosimilar (Shanghai Fudan-Zhangjiang Bio-Pharmaceutical) Phase Ⅰ Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Osteoporosis Details
Ostabolin (Zelos) ZT-031 Phase Ⅱ Azelon Pharmaceuticals Hip fracture, Menopausal symptoms, Postmenopausal osteoporosis, Osteoporosis Details
Teriparatide (Critical Pharmaceuticals) CP-046 Phase Ⅰ Critical Pharmaceuticals, University of Nottingham Osteoporosis Details
Recombinant parathyroid hormone (1-34) Phase Ⅲ Shanghai Zhongke Shenglongda Biotechnology Postmenopausal osteoporosis Details
Parathyroid hormone 1-84 (Kerun Biopharmaceutical) Phase Ⅱ Kerun Biopharmaceutical, Heze Buchang Pharmaceutical Osteoporosis Details
PCO-371 PCO-371,PCO371 Phase Ⅰ Chugai Hypoparathyroidism Details
Teriparatide biosimilar (Genemen Biotech) Phase Not Specified Genemen Biotech (Suzhou) Postmenopausal osteoporosis, Osteoporosis in men Details
KUR-115 KUR-115 Phase Ⅰ Kuros Biosciences, Baxter Bone disorders Details
Recombinant human parathyroid hormone (Shenzhen Salubris Pharmaceuticals) G56-W1; rhPTH(1-34) Phase Ⅱ Salubris Osteoporosis Details
Humanised anti-PTHrP antibody Phase Ⅱ Chugai Hypercalcemia, Metastatic cancer Details
KUR-111 KUR-111; I-0401 Phase Ⅱ Kuros Biosciences Fractures Details
BMD-1221 BMD-1221 Phase Not Specified University of Arkansas System, BiologicsMD Fractures Details
Teriparatide biosimilar (Rhein Minapharm Biogenetics) Phase Not Specified Rhein Minapharm Biogenetics Osteoporosis Details
Teriparatide biosimilar (National Institute of Dental and Craniofacial Research) rhPTH (1-34) (National Institute of Dental and Craniofacial Research) Phase Ⅲ National Institute of Dental and Craniofacial Research Primary hypothyroidism, DiGeorge Syndrome Details
Teriparatide transdermal (Corium International) Phase Ⅱ Corium International Osteoporosis Details
Parathyroid hormone analog (oral,Unigene/GlaxoSmithKline) GSK-768974 Phase Ⅱ Unigene Laboratories Postmenopausal osteoporosis Details
Recombinant human parathyroid hormone 1-34 (Shanghai United Cell Biotech) rhPTH (1-34) Phase Ⅲ Shanghai United Cell Biotechnology Osteoporosis Details
Teriparatide biosimilar (Dongguan Baolijian Bioengineer) Phase Ⅲ Dongguan baolijian biotech Postmenopausal osteoporosis Details
T3-sulfate (Bracco SpA) Phase Ⅱ Bracco Hypothyroidism Details
TransCon PTH ACP-014 Phase Ⅱ Ascendis Pharma Hypoparathyroidism Details
Teriparatide biosimilar (United Cell Biotechnology) IND Filing Shanghai United Cell Biotechnology Postmenopausal osteoporosis, Osteoporosis in men Details
Recombinant human parathyroid hormone (Beijing ShuangLu Pharmaceutical) Phase Ⅱ Beijing ShuangLu Pharmaceutical Osteoporosis Details
Hemoparatide hPTH-137 Phase Ⅰ Pharis Biotec Psoriasis Details
Teriparatide transdermal (Zosano Pharma) B-104; B-106; TH-0229; ThPTH (1-34); ZP-PTH,B 104; B 106; TH 0229; ZP PTH,B104; B106; TH0229 Phase Ⅱ Zosano Postmenopausal osteoporosis Details
Teriparatide intranasal (Marina Biotech) Phase Ⅱ Marina Biotech Osteoporosis Details
KUR-112 (Kuros Biosciences) KUR-112; I-040302; TGplPTH1-34 Phase Ⅰ Kuros Biosciences Bone cancer Details
Teriparatide transdermal (TransPharma) hPTH (1-34); ViaDerm-hPTH (1-34); ViaDor-hPTH (1-34) Phase Ⅱ TransPharma Medical, Lilly Osteoporosis Details
Teriparatide (Asubio Pharma) SUN-E3001; CHS-13340 Phase Ⅱ Daiichi Sankyo, Chugai Postmenopausal osteoporosis Details
Teriparatide (Azelon Pharmaceuticals) ZT-034 Phase Ⅱ Azelon Pharmaceuticals Postmenopausal osteoporosis Details
Recombinant Human Parathyroid Hormone (1-34), Shanghai Celgen Biopharmaceuticals Phase Ⅱ Shanghai Celgen Bio Osteoporosis Details
Recombinant parathyroid hormone 1-34 (Uni-Bio Science Group) rhPTH 1-34 (Uni-Bio Science Group);Uni-PH (1-34); Uni-rPH (1-34); Uni-PTH; UNI-PTH (1-34) BLA Filing Uni-Bio Science Group Postmenopausal osteoporosis Details
Teriparatide oral (Bone Medical) BN-003,BN 003,BN003 Phase Ⅱ Botanix Pharmaceuticals Osteoporosis Details
KUR-113 Fibrin-PTH; I-040202; KUR-113 Phase Ⅱ Kuros Biosciences Fractures Details

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