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Brief Information

Name:Parathyroid hormone receptor
Target Synonym:Parathyroid Hormone/Parathyroid Hormone-Related Protein Receptor,Seven Transmembrane Helix Receptor,PFE,Receptors, Parathyroid Hormone,Parathyroid Hormone 1 Receptor,Parathyroid Hormone Receptor 1,PTH/PTHr Receptor,PTH/PTHrP type I receptor,PTH1 receptor,PTH1R,PTHR,PTHR1,Parathyroid hormone/parathyroid hormone-related peptide receptor,EKNS
Number of Launched Drugs:22
Number of Drugs in Clinical Trials:27
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
PTR-H5222 Human Human PTH1R / PTHR1 Protein, His Tag
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Parathyroid hormone/parathyroid hormone-related peptide receptor is also known as Parathyroid hormone 1 receptor (PTH1R), PTHR1, PTH/PTHrP type I receptor (PTH/PTHr receptor), which belongs to the G-protein coupled receptor 2 family. PTH1R / PTHR1 is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Palopegteriparatide ACP-014; ACP014; ACP 014 Approved Ascendis Pharma TransCon, YORVIPATH EU Hypoparathyroidism Ascendis Pharma, Ascendis Pharma Bone Diseases As 2023-11-17 Hypoparathyroidism Details
Teriparatide biosimilar (Biosidus) rhPTH (1-34) (Biosidus) Approved Biosidus Osteofortil Argentina Osteoporosis Biosidus 2012-08-01 Osteoporosis Details
Abaloparatide ITM-058; BA-058-SC; BA-058-TD; BIM-44058; BA-058 Approved Ipsen ELADYNOS, Tymlos United States Osteoporosis, Postmenopausal Radius Health Inc 2017-04-28 Osteoporotic Fractures; Osteoporosis; Osteoporosis, Postmenopausal; Intervertebral Disc Degeneration; Fractures, Bone Details
Teriparatide biosimilar (Amega Biotech) rhPTH (1-34) (Amega Biotech) Approved Amega Biotech Osteoporosis Details
Teriparatide biosimilar (Pfenex) rhPTH (1-34) (Pfenex); PF-708 Approved Pfenex Biopharmaceuticals Inc Bonsity, Qutavina United States Osteoporosis, Postmenopausal; Glucocorticoid-induced osteoporosis; Osteoporosis Alvogen 2019-10-04 Osteoporosis; Osteoporosis, Postmenopausal; Glucocorticoid-induced osteoporosis Details
Teriparatide MN-10T; LY 333334; hPTH-1-34; EB-613 Approved Eli Lilly And Company Forteo, Forsteo, 复泰奥 United States Osteoporosis Eli Lilly And Company 2002-11-26 Ankle Fractures; Chronic Kidney Disease-Mineral and Bone Disorder; Anorexia Nervosa; Hypoparathyroidism; Periodontitis; Fractures, Bone; Osteoarthritis, Knee; Back Pain; Spinal Fractures; Humeral Fractures; Femoral Neck Fractures; Cartilage Diseases; Hypocalcemia; Colles' Fracture; Osteoporosis, Postmenopausal; Menopausal symptoms; Spinal Cord Injuries; Bone Diseases, Metabolic; Osteoporosis; Alveolar Bone Loss; Hyperparathyroidism, Secondary; Drug-Related Side Effects and Adverse Reactions Details
Parathyroid hormone (Shire) NPSP-795; rhPTH (1-84); rhPTH-1-84; PTH (1-84); SB-423562; PTH 1-84; NPSP-558; SHP-635; SHP-634; ALX-111; 423562; EBP-05; EB-612 Approved Shire Natpara, Preotact, Natpar United States Hypoparathyroidism Nps Pharmaceuticals, Inc 2006-04-24 Osteoporosis; Bone Diseases, Endocrine; Osteoporosis, Postmenopausal; Hypocalcemia; Psoriasis; Hypoparathyroidism; Hyperparathyroidism Details
Teriparatide biosimilar (Intas Pharmaceuticals) rhPTH (1-34) (Intas Pharmaceuticals); INTG8; INTG-8 Approved Intas Biopharmaceuticals Terifrac India Osteoporosis Intas Biopharmaceuticals 2010-12-01 Osteoporosis Details
Teriparatide biosimilar (Gedeon Richter) rhPTH (1-34) (Gedeon Richter) Approved Gedeon Richter Plc Terrosa EU Osteoporosis Gedeon Richter Plc 2017-01-04 Osteoporosis; Fractures, Stress Details
Teriparatide biosimilar (Salubris) SAL056; G56-W1; SAL-001 Approved Shenzhen Salubris Pharmaceuticals Co Ltd 欣复泰 Mainland China Osteoporosis, Postmenopausal Suzhou Genemen Biotech Co Ltd 2019-09-29 Osteoporosis, Postmenopausal Details
Teriparatide biosimilar (USV) Approved Usv Ltd Osteoporosis Details
Teriparatide biosimilar (Strides Pharma) SBL-001 Approved Strides Pharma Kauliv EU Osteoporosis; Osteoporosis, Postmenopausal Strides Pharma (Cyprus) Ltd 2023-01-12 Osteoporosis; Osteoporosis, Postmenopausal Details
Teriparatide biosimilar (STADA Arzneimittel AG) rhPTH (1-34) (STADA Arzneimittel AG) Approved Stada Arzneimittel Ag Movymia EU Osteoporosis Stada Arzneimittel Ag 2017-01-11 Osteoporosis Details
Recombinant parathyroid hormone biosimilar(Chongqing Fujin Biological Medicine) Approved Chongqing Fujin Biological Medicine Co Ltd Details
Recombinant Human Parathyroid Hormone (1-34), Shanghai Fosunpharma Approved Shanghai Fosun Pharmaceutical (Group) Co Ltd Details
Teriparatide acetate hPTH (1-34) acet. H2O; AK-159; MN-10-T Approved Union Square Ventures Llc Parathar, Teribone Japan Osteoporosis; Hypocalcemia null 1987-03-31 Osteoporosis; Hypocalcemia Details
Teriparatide biosimilar (Theramex) Approved Theramex Ireland Ltd Livogiva EU Osteoporosis Theramex Ireland Ltd 2020-08-27 Osteoporosis Details
Teriparatide biosimilar (Shanghai United Cell ) Approved Shanghai United Cell Biotechnology Co Ltd Mainland China Osteoporosis Shanghai United Cell Biotechnology Co Ltd 2017-03-22 Osteoporosis Details
Teriparatide biosimilar (Beijing Bokangjian Gene) Approved Beijing Genetech Pharmaceutical Co Ltd 博固泰 Mainland China Osteoporosis Beijing Genetech Pharmaceutical Co Ltd 2024-01-16 Osteoporosis; Osteoporosis, Postmenopausal Details
Teriparatide biosimilar (Virchow/Sun) rhPTH (1-34) (Virchow/Sun) Approved Sun Pharmaceutical Industries Ltd, Virchow Group Bonista, Osteotide EU Osteoporosis; Osteoporosis, Postmenopausal Sun Pharmaceutical Industries (Europe) Bv Osteoporosis; Osteoporosis, Postmenopausal Details
Teriparatide biosimilar (CinnaGen) rhPTH (1-34) (CinnaGen) Approved Cinnagen CinnoPar Iran Osteoporosis Cinnagen 2013-01-01 Osteoporosis Details
Teriparatide biosimilar (Zydus Cadila) rhPTH (1-34) (Zydus Cadila) Approved Zydus Cadila India Osteoporosis Zydus Cadila 2014-01-01 Osteoporosis Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Teriparatide biosimilar (National Institute of Dental and Craniofacial Research) rhPTH (1-34) (National Institute of Dental and Craniofacial Research) Phase 3 Clinical National Institute Of Dental And Craniofacial Research DiGeorge Syndrome; Hypothyroidism; Hypoparathyroidism Details
Teriparatide biosimilar (Shanghai CAS Shenglongda Biotech) Phase 3 Clinical Shanghai Zhongke Shenglongda Biotechnology (Group) Co Ltd Osteoporosis, Postmenopausal Details
Parathyroid hormone 1-84 (Kerun Biopharmaceutical) Phase 3 Clinical Chongqing Kerun Biologic Pharmaceutical Development Co Ltd Osteoporosis, Postmenopausal; Hypoparathyroidism Details
Eneboparatide AZP-3601 Phase 3 Clinical Harvard Medical School, Massachusetts General Hospital Endocrine System Diseases; Parathyroid Diseases; Hypoparathyroidism Details
Teriparatide transdermal (Corium International) Phase 2 Clinical Corium International Inc Osteoporosis Details
Teriparatide transdermal (Zosano Pharma) B-106; B-104; ZP-PTH; ThPTH (1-34); TH-0229 Phase 2 Clinical Zosano Pharma Corp Osteoporosis; Osteoporosis, Postmenopausal Details
KUR-113 KUR-113; I-040202; Fibrin-PTH Phase 2 Clinical Kuros Biosciences Spinal Diseases; Intervertebral Disc Degeneration; Wounds and Injuries Details
T3-sulfate (Bracco SpA) Phase 2 Clinical Bracco Spa Hypothyroidism Details
Recombinant Human Parathyroid Hormone (1-34)(Shanghai Celgen Biopharmaceuticals) Phase 2 Clinical Shanghai Celgen Bio-Pharmaceutical Co Ltd Osteoporosis Details
KUR-111 I-0401; KUR-111 Phase 2 Clinical Kuros Biosciences Fractures, Bone Details
MT-1013 MT-1013 Phase 2 Clinical Shaanxi Micot Technology Co Ltd Hyperparathyroidism, Secondary Details
Teriparatide biosimilar (Shanghai Fudan-Zhangjiang Bio-Pharmaceutical) Phase 1 Clinical Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd Osteoporosis Details
PCO-371 PCO-371 Phase 1 Clinical Chugai Pharmaceutical Co Ltd Hypoparathyroidism Details
Hemoparatide hPTH-137 Phase 1 Clinical Pharis Biotec Psoriasis Details
EXT-608 EXT-608 Phase 1 Clinical Extend Biosciences Inc Details
Teriparatide biosimilar(Hybio Pharmaceutical) Phase 1 Clinical Hybio Pharmaceutical Co Ltd Osteoporosis, Postmenopausal Details
RT-102(Rani) RT-102 Phase 1 Clinical Rani Therapeutics Holdings Inc Osteoporosis Details
MBX-2109 MBX-2109 Phase 1 Clinical MBX Biosciences Inc Details
Parathyroid hormone 1-84(Sichuan Luzhou Buchang Biopharmaceutical) Phase 1 Clinical Sichuan Luzhou Buchang Biopharmaceutical Co Ltd Hypocalcemia Details
MT-1009 MT-1009 Phase 1 Clinical Shaanxi Micot Technology Co Ltd Osteoporosis; Glucocorticoid-induced osteoporosis Details
BMD-1221 BMD-1221 Clinical University Of Arkansas System Fractures, Bone Details

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