Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
user
  1. Dashboard
  2. My Profile
  3. My Address
  4. My Orders
  5. Acro Membership
Login Register
Recombinant Proteins ClearClear history
Recombinant Proteins CloseClose
Browse Products By Molecule Name a-zA-Z
TL1A Hot |GMP IL-2 Hot |Streptavidin（SA） Hot |Claudin 18.2 |Cadherin-17 
0
There is no goods in the shopping cart !
My Cart|Check Out
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > RENIN

RENIN

Brief Information

Name:Renin
Target Synonym:REN,Renin,Angiotensinogenase,Angiotensin-Forming Enzyme,Renin Precursor, Renal,HNFJ2,EC:3.4.23.15,EC 3.4.23.15,EC 3.4.23
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Approved

Product ListCompare or Buy

Product> Filter Results
By Product Status:
By Product Category:
By Species:
By Tag:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
REN-M5222 Mouse Mouse RENIN Protein, His Tag
REN-M5222-structure
REN-M5222-sds
REN-H5221 Human Human RENIN Protein, His Tag
REN-H5221-structure
REN-H5221-sds
ACRO Quality

Synonym Name

REN,FLJ10761,Renin,angiotensinogenase

Background

Renin is also known as REN and angiotensinogenase, is a circulating enzyme that participates in the body's renin-angiotensin system (RAS), and plays an essential role in the elevation of arterial blood pressure and increased sodium retention by the kidney. Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. Renin is secreted from kidney cells, which are activated via signaling from the macula densa, which responds to the rate of fluid flow through the distal tubule, by decreases in renal perfusion pressure (through stretch receptors in the vascular wall), and by sympathetic nervous stimulation, mainly through beta-1 receptor activation. Renin can bind to ATP6AP2, which results in a fourfold increase in the conversion of angiotensinogen to angiotensin I over that shown by soluble renin. In addition, renin binding results in phosphorylation of serine and tyrosine residues of ATP6AP2. The level of renin mRNA appears to be modulated by the binding of HADHB, HuR and CP1 to a regulatory region in the 3' UTR. An over-active renin-angiotension system leads to vasoconstriction and retention of sodium and water. These effects lead to hypertension. Therefore, renin inhibitors can be used for the treatment of hypertension.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Aliskiren Hemifumarate/Amlodipine Besilate/Hydrochlorothiazide Approved Novartis Pharma Ag Rasitrio, Amturnide United States Hypertension null 2010-12-21 Hypertension; Essential Hypertension Details
Aliskiren Approved Mainland China Essential Hypertension Novartis Pharma Ag 2010-03-26 Essential Hypertension Details
Aliskiren Hemifumarate SPP-100; SPP-100A; SPP-100B; CGP-60536; CGP-60536B Approved Novartis Pharma Ag Enviage, Rasilez, Riprazo, Sprimeo, Tekturna, 锐思力 United States Hypertension Noden Pharma Dac 2007-03-05 Myocardial Ischemia; Heart Failure; Diabetes Mellitus, Type 2; Glomerulonephritis, IGA; Myocardial Infarction; Coronary Artery Disease; Hypertension; Hypertrophy, Left Ventricular; Diabetic macular oedema; Cardiovascular Diseases; Essential Hypertension; Diabetic Nephropathies; Kidney Failure, Chronic; Overweight; Diabetes Mellitus Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
MT-2765 MT-2765 Phase 3 Clinical Mitsubishi Tanabe Pharma Corp Hypertension Details
SP-20104 (Sarfez Pharmaceuticals) SP-20104 Phase 2 Clinical 1 A Pharma Gmbh Glomerulosclerosis, Focal Segmental Details
Imarikiren hydrochloride TAK-272; SCO-272 Phase 2 Clinical Takeda Pharmaceutical Co Ltd Kidney Diseases; Hypertension; Diabetic Nephropathies; Hepatic Insufficiency Details
SPH-3127 SPH-3127 Phase 3 Clinical Mitsubishi Tanabe Pharma, Shanghai Pharmaceuticals Holding Co Ltd Kidney Diseases; Hypertension; Psoriasis; Essential Hypertension; Diabetic Nephropathies; Colitis, Ulcerative Details

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Email
Email
order@acrobiosystems.com
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA
linkedin twitter facebook youtube

Leave a message

Copyright © 2017 ACROBiosystems. All Rights Reserved
|Related Links|Privacy Policy|Terms and Conditions|Legal|Sitemap