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RENIN

RENIN Molecule Information

Name:Renin
Target Synonym:EC 3.4.23,REN,Renin,Angiotensinogenase,Angiotensin-Forming Enzyme,Renin Precursor, Renal,HNFJ2,EC:3.4.23.15,EC 3.4.23.15
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
REN-M5222 Mouse Mouse RENIN Protein, His Tag
REN-M5222-structure
REN-M5222-sds
REN-H5221 Human Human RENIN Protein, His Tag
REN-H5221-structure
REN-H5221-sds

RENIN Molecule Synonym Name

REN,FLJ10761,Renin,angiotensinogenase

RENIN Molecule Background

Renin is also known as REN and angiotensinogenase, is a circulating enzyme that participates in the body's renin-angiotensin system (RAS), and plays an essential role in the elevation of arterial blood pressure and increased sodium retention by the kidney. Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. Renin is secreted from kidney cells, which are activated via signaling from the macula densa, which responds to the rate of fluid flow through the distal tubule, by decreases in renal perfusion pressure (through stretch receptors in the vascular wall), and by sympathetic nervous stimulation, mainly through beta-1 receptor activation. Renin can bind to ATP6AP2, which results in a fourfold increase in the conversion of angiotensinogen to angiotensin I over that shown by soluble renin. In addition, renin binding results in phosphorylation of serine and tyrosine residues of ATP6AP2. The level of renin mRNA appears to be modulated by the binding of HADHB, HuR and CP1 to a regulatory region in the 3' UTR. An over-active renin-angiotension system leads to vasoconstriction and retention of sodium and water. These effects lead to hypertension. Therefore, renin inhibitors can be used for the treatment of hypertension.

RENIN References

RENIN Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Aliskiren Hemifumarate/Amlodipine Besilate/Hydrochlorothiazide Approved Novartis Pharma Ag Rasitrio, Amturnide United States Hypertension s:4:"null"; 2010-12-21 Hypertension; Essential Hypertension Details
Aliskiren Hemifumarate/Hydrochlorothiazide Approved Novartis Pharma Ag Rasilez HCT, Tekturna HCT EU Essential Hypertension s:16:"Noden Pharma Dac"; 2008-01-18 Hypertension; Essential Hypertension Details
Aliskiren Approved N; Details
Aliskiren Hemifumarate SPP-100; SPP-100A; SPP-100B; CGP-60536; CGP-60536B Approved Novartis Pharma Ag 锐思力, Enviage, Rasilez, Riprazo, Sprimeo, Tekturna Mainland China Essential Hypertension s:16:"Noden Pharma Dac"; 2007-03-05 Heart Failure; Diabetes Mellitus, Type 2; Coronary Artery Disease; Hypertension; Diabetic macular oedema; Cardiovascular Diseases; Essential Hypertension; Kidney Failure, Chronic Details

RENIN Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Imarikiren hydrochloride SCO-272; TAK-272 Phase 2 Clinical Takeda Pharmaceutical Co Ltd Kidney Diseases; Hypertension; Hepatic Insufficiency; Diabetic Nephropathies Details
SP-20104 (Sarfez Pharmaceuticals) SP-20104 Phase 2 Clinical 1 A Pharma Gmbh Glomerulosclerosis, Focal Segmental Details
IONIS-AGT-LRx IONISAGTLRx; ISIS-757456; ISISAGTLRx Phase 2 Clinical Ionis Pharmaceuticals Inc Hypertension Details

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