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SCARB1

Brief Information

Name:Scavenger receptor class B member 1
Target Synonym:CLA-1,SR-BI,Collagen Type I Receptor, Thrombospondin Receptor-Like 1,Scavenger Receptor Class B, Member 1,Scavenger Receptor Class B Type III,CD36 Antigen-Like 1,CD36 Antigen,HDLQTL6,CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor)-Like 1,
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
SC1-H5258 Human Human SCARB1 / SR-B1 Protein, Fc Tag
SC1-H5258-structure
SC1-H5258-sds

Synonym Name

SCARB1,CD36L1,SRB1,CLA-1,SR-BI,HDLQTL6

Background

Scavenger receptor class B member 1 (SRB1) is also known as SR-BI, CD36 and LIMPII analogous 1 (CD36L1), CLA-1, is a member of the scavenger receptor family or CD36 family. CD36L1 is an integral membrane protein found in numerous cell types/tissues, including the liver and adrenal. SRB1 is receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. CLA-1 facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as high-density lipoprotein (HDL) and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. SCARB1 is, along with CD81, the receptor for the entry of the Hepatitis C virus glycoprotein E2 in liver cells, and binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. SRB1 plays an important role in the uptake of HDL cholesteryl ester.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ITX-5061 ITX-5061 Phase 2 Clinical Itherx Hepatitis C Details

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