SCARB1
SCARB1 Molecule Information
Name:Scavenger receptor class B member 1
Target Synonym:SRB1;Collagen type I receptor, thrombospondin receptor-like 1;Scavenger receptor class B member 1;CD_antigen=CD36;SCARB1;CD36 antigen-like 1;CLA-1;CLA1;CD36L1 ;SR-BI;CD36 and LIMPII analogous 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase ?
SCARB1 Molecule Synonym Name
SCARB1,CD36L1,SRB1,CLA-1,SR-BI,HDLQTL6
SCARB1 Molecule Background
Scavenger receptor class B member 1 (SRB1) is also known as SR-BI, CD36 and LIMPII analogous 1 (CD36L1), CLA-1, is a member of the scavenger receptor family or CD36 family. CD36L1 is an integral membrane protein found in numerous cell types/tissues, including the liver and adrenal. SRB1 is receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. CLA-1 facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as high-density lipoprotein (HDL) and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. SCARB1 is, along with CD81, the receptor for the entry of the Hepatitis C virus glycoprotein E2 in liver cells, and binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. SRB1 plays an important role in the uptake of HDL cholesteryl ester.
SCARB1 References
- Acton S., et al., 1996, Science 271 (5248): 518¨C20.
- Duggan AE., et al., 2002, J. Exp. Zool. 292 (5): 430¨C4.
- Kapadia SB., et al., 2007, J. Virol. 81 (1): 374¨C83.
- Scarselli E., et al., 2002, EMBO J. 21:5017-5025.
SCARB1 Clinical Drug Information
| Name |
Research Code |
Research Phase |
Company |
Indications |
Clinical Trials |
| ITX-5061 |
ITX-5061,ITX5061 |
Phase Ⅱ |
iTherX |
HCV infection |
Details
|
A-Z