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GMP-SCFH25-Cell-based assay

GMP Human SCF Protein (Cat. No. GMP-SCFH25) stimulates proliferation of Mo7e cell line. The specific activity of GMP Human SCF Protein is > 5.00ⅹ10^5 IU/mg, which is calibrated against human SCF WHO International Standard (NIBSC code: 91/682) (QC tested).

SCF-H5219-Cell-based assay

Human SCF (26-189), premium grade (Cat. No. SCF-H5219) stimulates proliferation of Mo7e cells. The specific activity of Human SCF Protein, premium grade is > 5.00×10^5 IU/mg, which is calibrated against human SCF WHO International Standard (NIBSC code: 91/682) (QC tested).


Biotinylated Human SCF, Avitag,His Tag (Cat. No. SCF-H82E1) captured on Biotin CAP-Series S Sensor Chip can bind Human CD117, His Tag (Cat. No. CD7-H52H4) with an affinity constant of 0.236 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).


Immobilized Human SCF (26-189), premium grade (Cat. No. SCF-H5219) at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD117, His,Avitag (Cat. No. CD7-H82E6) with a linear range of 0.02-0.3 μg/mL (QC tested).

Synonym Name



Stem Cell Factor is also known as SCF, kit-ligand, KL, steel factor, KITLG, FPH2,  KL-1, Kitl, MGF, SCF, SF, or SHEP7, and  is a cytokine that binds to the c-Kit receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis. The soluble and transmembrane forms of the protein are formed by alternative splicing of the same RNA transcript.Soluble and transmembrane SCF is produced by fibroblasts and endothelial cells. Soluble SCF has a molecular weight of 18,5 KDa and forms a dimer. SCF plays an important role in the hematopoiesis during embryonic development. Sites where hematopoiesis takes place, such as the fetal liver and bone marrow, all express SCF. During development, the presence of the SCF also plays an important role in the localization of melanocytes, cells that produce melanin and control pigmentation. SCF plays a role in the regulation of HSCs in the stem cell niche in the bone marrow. SCF may be used along with other cytokines to culture HSCs and hematopoietic progenitors. The expansion of these cells ex-vivo (outside the body) would allow advances in bone-marrow transplantation, in which HSCs are transferred to a patient to re-establish blood formation.

Clinical and Translational Updates

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