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Your Position: Home > SCF

SCF

SCF Product List

Cat. No. Species Product Description Structure Purity Feature
SCF-H82E1 Human Biotinylated Human SCF / KITLG Protein, Avi Tag (Avitag™)
SCF-H82E1-structure
SCF-H82E1-sds
SCF-H82E1-elisa_1
SCF-H4212 Human ActiveMax® Recombinant Human SCF /KITLG
SCF-H4212-structure
SCF-H4212-sds
SCF-H4212-elisa_1
SCF-M5228 Mouse Mouse SCF / KITLG Protein
SCF-M5228-structure
SCF-M5228-sds
SCF-M5228-elisa_1

SCF Molecule Synonym Name

KITLG,FPH2,KL-1,Kitl,MGF,SCF,SF,SHEP7,KL

SCF Molecule Background

Kit ligand (KITLG) is also known as stem cell factor (SCF), mast cell growth factor (MGF), steel factor (SF), which belongs to the SCF family, and is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein. KITLG is the ligand for the receptor-type protein-tyrosine kinase KIT. SCF / MGF plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG / SCF binding can activate several signaling pathways. KITLG / SF Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG / SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG / SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG / SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1, 4, 5 - trisphosphate. KITLG / SCF acts synergistically with other cytokines, probably interleukins.

SCF References

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