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Your Position: Home > Complement Component C5a

Complement Component C5a

Brief Information

Name:C5a anaphylatoxin chemotactic receptor
Target Synonym:C5AR,Complement Component 5 Receptor 1 (C5a Ligand),C5a Anaphylatoxin Chemotactic Receptor,Complement C5a Receptor 1,C5a Anaphylatoxin Receptor,C5AR1,C5a Anaphylatoxin Chemotactic Receptor 1,Complement Component 5a Receptor 1,C5a Ligand,C5A,C5R1,CD88,CD88 Antigen,Complement Component 5 Receptor 1,Receptor, Anaphylatoxin C5a,C5a-R
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved
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Synonym Name

C5a,Complement Component 5a

Background

Human Complement Component C5a (C5a) is also known as C5,and is a protein fragment released from complement component C5.,is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells; C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation; C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism; C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system; C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.

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