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Complement Component C5a

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Cat. No. Species Product Description Structure Purity Feature
C5A-H525a Human Human Complement Component C5a Protein, Fc Tag
C5A-C5118 Cynomolgus Cynomolgus Complement Component C5a Protein, Tag Free
C5A-M51H4 Mouse Mouse Complement Component C5a Protein, His Tag
C5A-H5116 Human Human Complement Component C5a Protein, Tag Free

Complement Component C5a Molecule Synonym Name

C5a,Complement Component 5a

Complement Component C5a Molecule Background

Human Complement Component C5a (C5a) is also known as C5,and is a protein fragment released from complement component C5.,is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells; C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation; C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism; C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system; C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.

Complement Component C5a References

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