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Serpin A1

Brief Information

Target Synonym:Alpha-1-antiproteinase,PRO2209,Serpin Family A Member 1,alpha 1-Antitrypsin,Protease Inhibitor 1 (Anti-Elastase), Alpha-1-Antitrypsin,Alpha-1 Protease Inhibitor,Serpin A1,AAT,PI,Serpin Peptidase Inhibitor Clade A (Alpha-1antiproteinase, Antitrypsin) Member 1,Serine (Or Cysteine) Proteinase Inhibitor, Clade A, Member 1,Alpha-1-Antitrypsin Short Transcript Variant 1C4,Serpin Peptidase Inhibitor Clade A Member 1,Alpha-1-Antitrypsin Null,Alpha-1 Antitrypsin,Alpha-1-Antitrypsin,Alpha1AT,PRO2275,NNIF,
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
SE1-H5226 Human Human Serpin A1 Protein, His Tag
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Serpin A1 is also known as Alpha-1-antitrypsin (A1AT), serum trypsin inhibitor, alpha-1 proteinase inhibitor (A1PI), AAT, which belongs to the serpin family. Most serpins inactivate enzymes by binding to them covalently, requiring very high levels to perform their function. Like all serine protease inhibitors, A1AT has a characteristic secondary structure of beta sheets and alpha helices. Serpin A1 / A1AT is inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form of SerpinA1 inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Serpin A1 / A1AT protects tissues from enzymes of inflammatory cells, especially neutrophil elastase. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD).

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Alfalastin (LFB SA) Approved Lfb Biotechnologies Sas Alfalastin France alpha 1-Antitrypsin Deficiency Lfb Biotechnologies Sas 2005-08-01 alpha 1-Antitrypsin Deficiency Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Fazirsiran TAK-999; ADS-001; ARO-AAT Phase 3 Clinical Arrowhead Pharmaceuticals Inc, Takeda Pharmaceutical Co Ltd alpha 1-Antitrypsin Deficiency; Hepatic Insufficiency Details
Belcesiran DCR-A1AT Phase 2 Clinical Dicerna Pharmaceuticals Inc, Alnylam Pharmaceuticals Inc alpha 1-Antitrypsin Deficiency Details
INBRX-101 AAT-IgG-Fc; AAT-Fc; rhAAT-Fc; AT-292; INBRX-101 Phase 2 Clinical Inhibrx alpha 1-Antitrypsin Deficiency; Emphysema Details
VX-864 VX-864 Phase 2 Clinical Vertex Pharmaceuticals Incorporated alpha 1-Antitrypsin Deficiency Details
KB-408 KB-408 Phase 1 Clinical Krystal Biotech Inc alpha 1-Antitrypsin Deficiency Details
VX-668 VX-668; VX668 Phase 1 Clinical Vertex Pharmaceuticals Incorporated alpha 1-Antitrypsin Deficiency Details
WVE-006 WVE-006 Phase 1 Clinical Wave Life Sciences Ltd alpha 1-Antitrypsin Deficiency Details
VX-634 VX-634 Phase 1 Clinical Vertex Pharmaceuticals Incorporated alpha 1-Antitrypsin Deficiency Details
Alpha-1 antitrypsin (Kalytera Therapeutics) Clinical Clalit Health Services Details

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