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Serpin A8

Serpin A8 Product List

Cat. No. Species Product Description Structure Purity Feature
SE8-H5227 Human Human Serpin A8 / AGT Protein
SE8-H5227-structure
SE8-H5227-sds

Serpin A8 Molecule Synonym Name

Angiotensinogen,SerpinA8,AGT,ANHU

Serpin A8 Molecule Background

Serpin A8 also known as angiotensinogen (AGT) , is a member of the serpin family. It is an ¦Á-2-globulin that is expressed by the liver and secreted in plasma. As essential component of the renin-angiotensin system (RAS), Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III) in lowered blood pressure by the enzyme renin. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3 stimulates aldosterone release. Defects in AGT are a cause of renal tubular dysgenesis (RTD).

Serpin A8 References

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