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SOD1 Molecule Information

Name:Superoxide dismutase
Target Synonym:Superoxide dismutase 1;Superoxide dismutase [Cu-Zn];hSod1;SOD1
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:19
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
SO1-H5148 Human Human SOD1 / Cu-Zn SOD Protein, His Tag

SOD1 Molecule Synonym Name

SOD1,Superoxide dismutase 1,hSod1

SOD1 Molecule Background

Superoxide dismutase [Cu-Zn] (SOD1) is also known as superoxide dismutase 1 (hSod1), an enzyme that in humans is encoded by the SOD1 gene, located on chromosome 21. SOD1 can bind copper and zinc ions and is one of three superoxide dismutases responsible for destroying free superoxide radicals in the body. The encoded isozyme (SOD1) is a soluble cytoplasmic and mitochondrial intermembrane space protein, acting as a homodimer to convert naturally occurring, but harmful, superoxide radicals to molecular oxygen and hydrogen peroxide. Furthermore, the mutations of SOD1 gene can result in a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord.

SOD1 References

SOD1 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Orgotein Approved GT Biopharma, Meiji Seika Pharma Rheumatic disorders, Cystitis, Radiation injuries Details

SOD1 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
INO-6001 INO-6001; INO-6002,INO 6001; INO6001; INO6002 Preclinical Rocket Pharmaceuticals Age-related macular degeneration (AMD), Diabetic retinopathy Details
NI-204 AP-101-Neurimmune; TDI-200; NI-204A Preclinical Neurimmune, ALS Therapy Development Institute Amyotrophic lateral sclerosis (ALS) Details
Avasopasem manganese GC-4419; KM-4419; M-40419; SC-72325A Phase Ⅲ Galera, ActivBiotics, MetaPhore Pharmaceuticals Oral mucositis, Stomatitis Details
BMX-010 BMX-010; MnTE-2-PyP; MnTE-2-PyP5+,BMX 010; MnTE 2 PyP; MnTE 2 PyP5+,BMX010; MnTE2PyP; MnTE2PyP5+ Phase Ⅱ Duke University, BioMimetix Plaque psoriasis, Atopic dermatitis Details
Nicardipine/Superoxide dismutase Phase Ⅰ Hybrid Medical Peyronie disease Details
Superoxide dismutase liposomal (Apeiron Biologics) APN-201 Phase Ⅲ Polymun Scientific, Apeiron Biologics Radiodermatitis, Peyronie's disease Details
Sudismase (Chiron) CG-4505,CG 4505,CG4505 Phase Ⅲ Chiron, Cephalon Osteoarthritis (OA), Transplant rejection Details
Stroquinan SP-8203; SP-8203 hydrochloride; SP8203 HCL Phase Ⅱ Shin Poong Pharmaceutical Stroke Details
CDRI-81-470 CDRI-81-470 Phase Not Specified Central Drug Research Institute Worm infection Details
Tofersen 99mTc-MAG3-BIIB067; BIIB-067; ISIS-333611 Phase Ⅲ Ionis Pharmaceuticals, Ludwig Institute for Cancer Research, Biogen Amyotrophic lateral sclerosis (ALS) Details
Imisopasem Manganese GC-4403; M-40403; SC-72325 Phase Ⅱ MetaPhore Pharmaceuticals Postoperative pain, Cancer related pain Details
NK-341 NK-341 Phase Ⅲ Nippon Kayaku Arrhythmia, ischaemic heart disorder Details
GC-4711 GC-4711 Phase Ⅱ Galera Non small cell lung cancer (NSCLC) Details
Superoxide dismutase (Ube Industries) FKU-871; r-hSOD Phase Ⅱ UBE, Astellas ischaemic heart disorder Details
Bis-choline tetrathiomolybdate WTX-101; ATN-224 Phase Ⅲ Wilson Therapeutics Wilson's disease Details
NV-52 NV-52; NV-07β Phase Ⅱ Novogen Ulcerative colitis, Crohn's disease, Inflammatory bowel disease Details
AEOL-10150 AEOL-10150 Phase Ⅰ Aeolus Pharmaceuticals Solid tumours, Idiopathic pulmonary fibrosis (IPF) Details
Superoxide dismutase (Weizmann Institute) rhSOD1 Phase Ⅱ Weizmann Institute of Science, JCR Pharmaceuticals, Merck Serono Amyotrophic lateral sclerosis (ALS), RSV infection, Neonatal respiratory distress syndrome, ischaemic heart disorder, Asthma Details
SOD1 miRNA therapy (University of Massachusetts Medical School) APB-102 Phase Not Specified University of Massachusetts Medical School, Apic Bio Amyotrophic lateral sclerosis (ALS) Details

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