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Stathmin 1

Stathmin 1 Molecule Information

Target Synonym:Protein Pr22,Phosphoprotein p19,LAP18,C1orf215,STMN1,Stathmin 1,Oncoprotein 18,Leukemia-Associated Phosphoprotein P18,Stathmin 1/Oncoprotein 18,Metablastin,Prosolin,Chromosome 1 Open Reading Frame 215,Testicular Tissue Protein Li 189,Transmembrane Protein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
ST1-H5149 Human Human Stathmin 1 / STMN1 Protein, His Tag

Stathmin 1 Molecule Synonym Name


Stathmin 1 Molecule Background

Stathmin (STMN1), a member of the stathmin family, is also known as Leukemia-associated phosphoprotein p18, Oncoprotein 18 (Op18), Phosphoprotein p19 (pp19), Protein Pr22 and pp17, which contains one SLD (stathmin-like) domain. The function of STMN1 as an important regulatory protein of microtubule dynamics has been well-characterized. Stathmin (STMN1) interacts with two molecules of dimeric ¦Á,¦Â-tubulin to form a tight ternary complex called the T2S complex.One mole of STMN1 binds to two moles of tubulin dimers through the stathmin-like domain (SLD).When STMN1 sequesters tubulin into the T2S complex, tubulin becomes non-polymerizable. Without tubulin polymerization, there is no microtubule assembly.STMN1 also promotes microtubule disassembly by acting directly on the microtubule ends.

Stathmin 1 References

Stathmin 1 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
pbi-shRNA STMN1 Lipoplex Phase 1 Clinical Gradalis Solid tumours Details

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