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Stathmin 1

Brief Information

Target Synonym:Protein Pr22,Phosphoprotein p19,LAP18,C1orf215,STMN1,Stathmin 1,Oncoprotein 18,Leukemia-Associated Phosphoprotein P18,Stathmin 1/Oncoprotein 18,Metablastin,Prosolin,Chromosome 1 Open Reading Frame 215,Testicular Tissue Protein Li 189,Transmembrane Protein C1orf215,Phosphoprotein 19,Stathmin,PP17,PR22,Op18,Pp19,Lag,SMN,FLJ32206
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
ST1-H5149 Human Human Stathmin 1 / STMN1 Protein, His Tag
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Stathmin (STMN1), a member of the stathmin family, is also known as Leukemia-associated phosphoprotein p18, Oncoprotein 18 (Op18), Phosphoprotein p19 (pp19), Protein Pr22 and pp17, which contains one SLD (stathmin-like) domain. The function of STMN1 as an important regulatory protein of microtubule dynamics has been well-characterized. Stathmin (STMN1) interacts with two molecules of dimeric ¦Á,¦Â-tubulin to form a tight ternary complex called the T2S complex.One mole of STMN1 binds to two moles of tubulin dimers through the stathmin-like domain (SLD).When STMN1 sequesters tubulin into the T2S complex, tubulin becomes non-polymerizable. Without tubulin polymerization, there is no microtubule assembly.STMN1 also promotes microtubule disassembly by acting directly on the microtubule ends.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
QRL-201 QRL201 Phase 1 Clinical QurAlis Corp Amyotrophic Lateral Sclerosis Details
pbi-shRNA STMN1 Lipoplex Phase 1 Clinical Gradalis Inc Solid tumours Details

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