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Carbonic Anhydrase II

Carbonic Anhydrase II Molecule Information

Name:Carbonic anhydrase II
Target Synonym:CAC;CA-II;Carbonic anhydrase C;Carbonate dehydratase II;Carbonic anhydrase II;CA2;Carbonic anhydrase 2
Number of Launched Drugs:8
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CA2-H5228 Human Human Carbonic Anhydrase II / CA2 Protein, His Tag

Carbonic Anhydrase II Molecule Synonym Name


Carbonic Anhydrase II Molecule Background

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes. CAs form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs rather slowly in the absence of a catalyst. One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. The active site of most carbonic anhydrases contains a zinc ion. They are, therefore, classified as metalloenzymes. There are at least five distinct CA families (¦Á, ¦Â, ¦Ã, ¦Ä and ¦Å). These families have no significant amino acid sequence similarity and in most cases are thought to be an example of convergent evolution. The ¦Á-CAs are found in humans. Carbonic anhydrase II (CA2) is also known as Carbonate dehydratase II, Carbonic anhydrase C, is one of fourteen forms of human ¦Á carbonic anhydrases. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal carbonic anhydrase allows the reabsorption of sodium ions in the proximal tubule. Carbonic anhydrase II has been shown to interact with Band 3 and Sodium-hydrogen antiporter 1.

Carbonic Anhydrase II References

Carbonic Anhydrase II Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Brinzolamide/Timolol Maleate Approved Alcon brinzolamide;timolol maleate ema

Decrease of intraocular pressure (IOP) in adult patients with open angle glaucoma or ocular hypertension for whom monotherapy provides insufficient IOP reduction.

Novartis Europharm Limited 2008-11-25 Ocular hypertension, Open-angle glaucoma, Glaucoma Details
Brinzolamide/Brimonidine Tartrate Approved Novartis SIMBRINZA fda NOVARTIS 2013-04-19 Ocular hypertension, Open-angle glaucoma Details
Methazolamide VVP-808 Approved Unknown NEPTAZANE fda LEDERLE 1959-01-26 Glaucoma Details
Brinzolamide AL-4862; ALO-4862 Approved Alcon AZOPT fda Ocular hypertension, Open-angle glaucoma NOVARTIS 1998-04-01 Ocular hypertension, Open-angle glaucoma Details
Dorzolamide Hydrochloride/Timolol Maleate/Brimonidine Tartrate PRO-122 Approved Laboratorios Sophia Ocular hypertension, Glaucoma Details
Topiramate McN-4853; RWJ-17021; TPM; W-6485; KW-6485P; SPN-538 Approved Janssen Topiramate 英国 Migraine, Epilepsy/Seizures 杨森 1995-01-01 00:00:00.0 Migraine, Epilepsy/Seizures Details
Phentermine Hydrochloride/Topiramate VI-0521 Approved Vivus QSYMIA fda VIVUS 2012-07-17 Obesity Details
Sultiame Riker-594 Approved Unknown Sultiam-neuraxpharm 100 mg Filmtabletten hma Epilepsy/Seizures neuraxpharm Arzneimittel GmbH
Elisabeth-Selbert-Str. 23
D-40764 Langenfeld
2016-11-18 Epilepsy/Seizures Details

Carbonic Anhydrase II Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Brinzolamide/Travoprost Phase Ⅲ Alcon Ocular hypertension, Glaucoma Details
Ondansetron/Topiramate Phase Ⅱ ADial Pharmaceuticals Alcoholism Details
Para-Toluenesulfonamide PTS-100; PTS-02; PTS-302; PTS-500; p-TSA; PTS NDA Filing Beijing Vision Drugs Development, Gongwin Biopharm, Tianjin Chase Sun Pharmaceutical, Tianjin Chase Sun Jiandakang Adenoid cystic carcinoma, Non small cell lung cancer (NSCLC), Hepatocellular carcinoma (HCC) Details

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