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Carbonic Anhydrase II

Brief Information

Name:Carbonic anhydrase II
Target Synonym:Carbonic anhydrase II,Carbonic Anhydrase B,EC:,Carbonate Dehydratase II,Carbonic Anhydrase C,EC,CA2,Epididymis Luminal Protein 76,Car2,HEL-76,Epididymis Secretory Protein Li 282,CA-II,CAC,CAII,HEL-S-282,Carbonic Anhydrase 2,Carbonic Dehydratase
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CA2-H5228 Human Human Carbonic Anhydrase II / CA2 Protein, His Tag
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Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes. CAs form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs rather slowly in the absence of a catalyst. One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. The active site of most carbonic anhydrases contains a zinc ion. They are, therefore, classified as metalloenzymes. There are at least five distinct CA families (¦Á, ¦Â, ¦Ã, ¦Ä and ¦Å). These families have no significant amino acid sequence similarity and in most cases are thought to be an example of convergent evolution. The ¦Á-CAs are found in humans. Carbonic anhydrase II (CA2) is also known as Carbonate dehydratase II, Carbonic anhydrase C, is one of fourteen forms of human ¦Á carbonic anhydrases. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal carbonic anhydrase allows the reabsorption of sodium ions in the proximal tubule. Carbonic anhydrase II has been shown to interact with Band 3 and Sodium-hydrogen antiporter 1.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Brinzolamide/Timolol Maleate Approved Alcon Azarga, Elazop EU Ocular Hypertension; Glaucoma, Open-Angle Novartis Europharm Ltd 2008-11-25 Glaucoma, Open-Angle; Ocular Hypertension; Glaucoma Details
Sultiame Riker-594 Approved Ospolot Sleep Apnea, Obstructive; Epilepsy Details
Brinzolamide/Brimonidine Tartrate Approved Novartis Pharma Ag Simbrinza United States Ocular Hypertension; Glaucoma, Open-Angle Alcon Laboratories Inc 2013-04-19 Glaucoma, Open-Angle; Ocular Hypertension; Glaucoma Details
Topiramate KW-6485P; McN-4853; RWJ-17021; W-6485; TPM; SPN-538; USL-255 Approved Johnson & Johnson Innovative Medicine Topamax, Topina, Conviban, Qudexy, Eprontia, 妥泰 United Kingdom Migraine Disorders; Epilepsy Johnson & Johnson Innovative Medicine 1995-01-01 Epilepsy, Generalized; Hypertension; Cognition; Tobacco Use Disorder; Migraine with Aura; Epilepsy, Absence; Sciatica; Obsessive-Compulsive Disorder; Gambling; Alcoholism; Epilepsy; Hypoxia-Ischemia, Brain; Parkinson Disease; Lennox Gastaut Syndrome; Stress Disorders, Post-Traumatic; Lymphoma; Cocaine-Related Disorders; Migraine without Aura; Alcohol Drinking; Obesity; Hyperlipidemias; Heart Defects, Congenital; Vascular Headaches; Affective Disorders, Psychotic; Mental Disorders; Mood Disorders; Alcohol-Induced Disorders; Peripheral Nervous System Diseases; Hypertriglyceridemia; Weight Loss; Pediatric Obesity; Headache; HIV Infections; Binge-Eating Disorder; Epilepsies, Partial; Seizures; Binge Drinking; Diabetes Mellitus, Type 2; Migraine Disorders; Marijuana Abuse; Contraception; Bipolar Disorder; Essential Tremor; Bulimia; Obesity, Morbid; Diabetic Neuropathies; Polyneuropathies; Pain, Postoperative; Glaucoma, Open-Angle; Epilepsy, Tonic-Clonic Details
Brinzolamide AL-4862; ALO-4862 Approved Alcon 派立明, Azopt United States Ocular Hypertension; Glaucoma, Open-Angle Sandoz 1998-04-01 Glaucoma, Open-Angle; Ocular Hypertension; Glaucoma Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Topiramate (PrevEp) PrevEp-004 Phase 2 Clinical PrevEP Inc Status Epilepticus; Epilepsy, Benign Neonatal Details

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