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Carbonic Anhydrase II

Brief Information

Name:Carbonic anhydrase II
Target Synonym:Carbonic Dehydratase,Carbonic anhydrase II,Carbonic Anhydrase C,CA2,EC 4.2.1.1,Carbonic Anhydrase B,EC:4.2.1.1,Carbonate Dehydratase II,Epididymis Secretory Protein Li 282,CA-II,CAC,CAII,Car2,HEL-76,Epididymis Luminal Protein 76,HEL-S-282,Carbonic Anhydra
Number of Launched Drugs:7
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CA2-H5228 Human Human Carbonic Anhydrase II / CA2 Protein, His Tag
CA2-H5228-structure
CA2-H5228-sds

Synonym Name

CA2,CA-II,CAII,Car2

Background

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes. CAs form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs rather slowly in the absence of a catalyst. One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. The active site of most carbonic anhydrases contains a zinc ion. They are, therefore, classified as metalloenzymes. There are at least five distinct CA families (¦Á, ¦Â, ¦Ã, ¦Ä and ¦Å). These families have no significant amino acid sequence similarity and in most cases are thought to be an example of convergent evolution. The ¦Á-CAs are found in humans. Carbonic anhydrase II (CA2) is also known as Carbonate dehydratase II, Carbonic anhydrase C, is one of fourteen forms of human ¦Á carbonic anhydrases. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal carbonic anhydrase allows the reabsorption of sodium ions in the proximal tubule. Carbonic anhydrase II has been shown to interact with Band 3 and Sodium-hydrogen antiporter 1.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Methazolamide VVP-808 Approved 尼目克司, Neptazane Mainland China Glaucoma s:4:"null"; 1959-01-26 Glaucoma Details
Brinzolamide/Timolol Maleate Approved Alcon Azarga Mainland China Ocular Hypertension; Glaucoma, Open-Angle s:29:"Alcon Laboratories (U.K.) Ltd"; 2008-11-25 Glaucoma, Open-Angle; Ocular Hypertension; Glaucoma Details
Sultiame Riker-594 Approved Ospolot N; Epilepsy Details
Brinzolamide AL-4862; ALO-4862 Approved Alcon 派立明, Azopt Japan Ocular Hypertension; Glaucoma, Open-Angle s:5:"Alcon"; 1998-04-01 Glaucoma, Open-Angle; Glaucoma; Ocular Hypertension Details
Phentermine Hydrochloride/Topiramate VI-0521 Approved Vivus Qnexa, Qsiva, Qsymia United States Obesity s:9:"Vivus Inc"; 2012-07-17 Kidney Diseases; Sleep Apnea Syndromes; Hepatic Insufficiency; Obesity; Diabetes Mellitus Details
Brinzolamide/Brimonidine Tartrate Approved Novartis Pharma Ag Simbrinza Mainland China Ocular Hypertension; Glaucoma, Open-Angle s:22:"Novartis Europharm Ltd"; 2013-04-19 Glaucoma, Open-Angle; Ocular Hypertension Details
Topiramate McN-4853; RWJ-17021; KW-6485P; W-6485; TPM; SPN-538 Approved Janssen Global Services Llc 妥泰, Topamax, Topina, Conviban, Qudexy United States Lennox Gastaut Syndrome s:29:"Upsher-Smith Laboratories Llc"; 1995-01-01 Epilepsy, Tonic-Clonic; Vascular Headaches; Hyperlipidemias; Affective Disorders, Psychotic; Migraine without Aura; Obesity; Alcoholism; Epilepsy, Generalized; Epilepsy; Migraine with Aura; Epilepsy, Absence; Lennox Gastaut Syndrome; Hypertension; Migraine Disorders; Diabetic Neuropathies; Polyneuropathies; Bulimia; Essential Tremor; Bipolar Disorder; Diabetes Mellitus, Type 2; Mood Disorders; Seizures; Epilepsies, Partial; Hypertriglyceridemia; Headache; Binge-Eating Disorder Details

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