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Your Position: Home > Carbonic Anhydrase II

Carbonic Anhydrase II

Brief Information

Name:Carbonic anhydrase II
Target Synonym:Carbonic anhydrase II,Carbonic Anhydrase B,EC:4.2.1.1,Carbonate Dehydratase II,Carbonic Anhydrase C,EC 4.2.1.1,CA2,Epididymis Luminal Protein 76,Car2,HEL-76,Epididymis Secretory Protein Li 282,CA-II,CAC,CAII,HEL-S-282,Carbonic Anhydrase 2,Carbonic Dehydratase
Number of Launched Drugs:7
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CA2-H5228 Human Human Carbonic Anhydrase II / CA2 Protein, His Tag
CA2-H5228-structure
CA2-H5228-sds

Synonym Name

CA2,CA-II,CAII,Car2

Background

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes. CAs form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs rather slowly in the absence of a catalyst. One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. The active site of most carbonic anhydrases contains a zinc ion. They are, therefore, classified as metalloenzymes. There are at least five distinct CA families (¦Á, ¦Â, ¦Ã, ¦Ä and ¦Å). These families have no significant amino acid sequence similarity and in most cases are thought to be an example of convergent evolution. The ¦Á-CAs are found in humans. Carbonic anhydrase II (CA2) is also known as Carbonate dehydratase II, Carbonic anhydrase C, is one of fourteen forms of human ¦Á carbonic anhydrases. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal carbonic anhydrase allows the reabsorption of sodium ions in the proximal tubule. Carbonic anhydrase II has been shown to interact with Band 3 and Sodium-hydrogen antiporter 1.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Phentermine Hydrochloride/Topiramate VI-0521 Approved Qnexa, Qsiva, Qsymia United States Obesity Vivus Inc 2012-07-17 Kidney Diseases; Sleep Apnea Syndromes; Hepatic Insufficiency; Obesity; Diabetes Mellitus Details
Methazolamide VVP-808 Approved 尼目克司, Neptazane Mainland China Glaucoma null 1959-01-26 Glaucoma Details
Brinzolamide/Timolol Maleate Approved Alcon Azarga Mainland China Ocular Hypertension; Glaucoma, Open-Angle Alcon Laboratories (U.K.) Ltd 2008-11-25 Glaucoma, Open-Angle; Ocular Hypertension; Glaucoma Details
Topiramate TPM; SPN-538; USL-255; KW-6485P; McN-4853; RWJ-17021; W-6485 Approved Janssen Global Services Llc 妥泰, Topamax, Topina, Conviban, Qudexy, Eprontia United States Lennox Gastaut Syndrome Upsher-Smith Laboratories Llc 1995-01-01 Lennox Gastaut Syndrome; Affective Disorders, Psychotic; Vascular Headaches; Hyperlipidemias; Migraine without Aura; Obesity; Alcoholism; Epilepsy, Generalized; Epilepsy; Migraine with Aura; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Hypertension; Migraine Disorders; Bulimia; Essential Tremor; Bipolar Disorder; Polyneuropathies; Diabetic Neuropathies; Mood Disorders; Diabetes Mellitus, Type 2; Epilepsies, Partial; Seizures; Binge-Eating Disorder; Headache; Hypertriglyceridemia Details
Brinzolamide/Brimonidine Tartrate Approved Novartis Pharma Ag Simbrinza Mainland China Ocular Hypertension; Glaucoma, Open-Angle Novartis Europharm Ltd 2013-04-19 Glaucoma, Open-Angle; Ocular Hypertension Details
Brinzolamide AL-4862; ALO-4862 Approved Alcon 派立明, Azopt Japan Ocular Hypertension; Glaucoma, Open-Angle Alcon 1998-04-01 Glaucoma, Open-Angle; Glaucoma; Ocular Hypertension Details
Sultiame Riker-594 Approved Ospolot Sleep Apnea, Obstructive; Epilepsy Details

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