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TFPI

TFPI Molecule Information

Name:Tissue factor pathway inhibitor
Target Synonym:Lipoprotein-associated coagulation inhibitor?TFPI?LACI?Extrinsic pathway inhibitor?EPI?TFPI1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase ?

TFPI Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
TFI-C52H3 Rhesus Rhesus macaque TFPI Protein
TFI-C52H3-structure
TFI-C52H3-sds
TFI-H8226 Human Biotinylated Human TFPI, ultra sensitivity (primary amine labeling)
TFI-H8226-structure
TFI-H8226-sds
TFI-H5226 Human Human TFPI Protein
TFI-H5226-structure
TFI-H5226-sds

TFPI Molecule Synonym Name

TFPI,LACI,TFPI1,EPI,TFI

TFPI Molecule Background

Tissue factor pathway inhibitor (TFPI) is also known as Extrinsic pathway inhibitor (EPI), Lipoprotein - associated coagulation inhibitor (LACI), is a plasma proteinase inhibitor synthesized by vascular endothelial cells and part of it is associated with glycosaminoglycans of these cells. TFPI is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). TFPI is a secreted protein with a N­terminal acidic region, three Kunitz (K) domains separated with by two linker regions, and a C­terminal basic region. The first K domain inhibits coagulation factor VIIa complexed to tissue factor (TF); The second K domain inhibits factor Xa; The third K domain binds to heparin; The C­terminal basic region may have several functions. For example, it plays an important role in binding of TFPI to cell surfaces.

TFPI References

TFPI Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Concizumab mAb-2021; NN-7415; NNC-0172-0000-2021; NNC-0172-2021; NNC-172-2021; mAbTFPI2021 ; Anti-TFPI,mAb2021; NN7415; NNC0172-0000-2021; NNC0172-2021; NNC172-2021; mAb-TFPI2021  Phase Ⅱ Novo Nordisk Hemophilia A, Hemophilia B Details
BAY-1093884 BAY-109; BAY-1093884,BAY1093884 Phase Ⅱ Bayer, MorphoSys Hemophilia Details

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