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Brief Information

Name:Tissue factor pathway inhibitor
Target Synonym:TFPI,Tissue Factor Pathway Inhibitor,Extrinsic Pathway Inhibitor,TFPI1,LACI,EPI,Anti-Convertin,TFI,Lipoprotein-associated coagulation inhibitor,Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor)
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
TFI-H5226 Human Human TFPI Protein, His Tag (active enzyme)
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Synonym Name



Tissue factor pathway inhibitor (TFPI) is also known as Extrinsic pathway inhibitor (EPI), Lipoprotein - associated coagulation inhibitor (LACI), is a plasma proteinase inhibitor synthesized by vascular endothelial cells and part of it is associated with glycosaminoglycans of these cells. TFPI is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). TFPI is a secreted protein with a N­terminal acidic region, three Kunitz (K) domains separated with by two linker regions, and a C­terminal basic region. The first K domain inhibits coagulation factor VIIa complexed to tissue factor (TF); The second K domain inhibits factor Xa; The third K domain binds to heparin; The C­terminal basic region may have several functions. For example, it plays an important role in binding of TFPI to cell surfaces.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Concizumab mAbTFPI2021; NN-7415; NNC-0172-0000-2021; Anti-TFPI; mAb-2021; NNC-0172-2021; NNC-172-2021 Approved Novo Nordisk A/S Alhemo Canada Hemophilia B Novo Nordisk Canada Inc 2023-04-17 Hemophilia A; Hemophilia B; Hemorrhage Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
KN-057 KN-057; KN057 Phase 3 Clinical Suzhou Alphamab Co Ltd Hemophilia A; Hemophilia B Details
MG-1113 MG-1113 Phase 1 Clinical GC Biopharma Corp Hemophilia A Details
AP-017 AP017; AP-017 Phase 1 Clinical Anyuan Pharmaceutical Technology (Shanghai) Co Ltd Hemophilia A; Hemophilia B Details

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