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Coagulation Factor II

Coagulation Factor II Molecule Information

Target Synonym:Thrombin light chain;Prothrombin;Thrombin heavy chain;Activation peptide fragment 2;F2;Activation peptide fragment 1;Coagulation factor II
Number of Launched Drugs:40
Number of Drugs in Clinical Trials:64
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
THN-H52H0 Human Human Coagulation Factor II / Thrombin Protein, His Tag

Coagulation Factor II Molecule Synonym Name

thrombin,Coagulation factor II

Coagulation Factor II Molecule Background

Prothrombin is also known as coagulation factor II (F2),which can be cleaved into the following 4 chains: activation peptide fragment 1, activation peptide fragment 2, thrombin light chain and thrombin heavy chain. Coagulation factor II (F2) is able to form a heterodimer with SERPINA5. The mutations of F2 gene can result in a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. Furthermore, thrombin converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Coagulation factor II (F2) can also play an important role in blood homeostasis, inflammation and wound healing.

Coagulation Factor II References

Coagulation Factor II Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Human prothrombin complex (Tonrol Biopharmaceuticals) Approved Tonrol cfda Bleeding, Hemophilia B, Congenital factor VII deficiency, Factor X deficiency 2015-06-25 Factor X deficiency, Hemophilia B, Congenital factor VII deficiency, Bleeding Details
Enoxaparin sodium biosimilar (Gland Pharma) Approved Gland Pharma Unstable angina, Deep vein thrombosis (DVT), Venous thromboembolism (VTE), Myocardial infarction (MI) Details
Thrombomodulin Alfa ART-123; TMD-123; AT-908,ART123 Approved Asahi Kasei Thrombomodulin Alfa 日本 Disseminated intravascular coagulation (DIC) 旭化成 2008-01-25 00:00:00.0 Disseminated intravascular coagulation (DIC) Details
Beriplast-P Approved CSL Behring Wound Healing, Bleeding Details
Fibrin patch (Ethicon/Omrix Biopharmaceuticals) Approved Johnson & Johnson human fibrinogen / human thrombin ema

 Supportive treatment in adult surgery where standard surgical techniques are insufficient (see section 5.1):

-   for improvement of haemostasis.

Omrix Biopharmaceuticals N. V. 2013-09-25 Bleeding Details
Dermatan sulfate MF-701; MF-777 Approved Mediolanum Farmaceutici Dermatan sulfate 意大利 Thrombosis, Venous thromboembolism (VTE), Thrombocytopenia Mediolanum Farmaceutici 1998-07-01 00:00:00.0 Thrombocytopenia, Venous thromboembolism (VTE), Thrombosis Details
Hirudin biosimilar (Rhein-Minapharm) Approved Rhein Minapharm Biogenetics Deep vein thrombosis (DVT) Details
Argatroban DK-7419; GN1600; MCI-9038; MD-805; MDI-805; OM-805 Approved Mitsubishi Tanabe Pharma, Pfizer Argatroban 日本 1990-01-01 00:00:00.0 Percutaneous coronary intervention (PCI), Thrombosis Details
Human fibrinogen/Human thrombin (Instituto Grifols) Approved Grifols human fibrinogen, human thrombin ema

Supportive treatment in adults where standard surgical techniques are insufficient:

  • for improvement of haemostasis
  • as suture support in vascular surgery
Instituto Grifols, S.A. 2017-11-10 Bleeding Details
Antithrombin Gamma KW-3357 Approved Kyowa Hakko Kirin Antithrombin Gamma 日本 Hereditary antithrombin deficiency, Disseminated intravascular coagulation (DIC) 协和发酵麒麟 2015-07-03 00:00:00.0 Disseminated intravascular coagulation (DIC), Hereditary antithrombin deficiency Details
Antithrombin III (CSL Behring) BI51.017 Approved CSL Behring Antithrombin III (CSL Behring) 日本 Thrombosis, Disseminated intravascular coagulation (DIC) CSL Behring 1987-08-02 00:00:00.0 Disseminated intravascular coagulation (DIC), Thrombosis, Thrombosis Details
Human fibrinogen concentrate (CSL Behring) Approved CSL Behring Riastap hma Afibrinogenaemia CSL Behring
Emil-von-Behring-Straße 76
35041 Marburg
2010-07-27 Afibrinogenaemia Details
Enoxaparin sodium biosimilar (Sahar International Trading) Approved Sahar International Trading Unstable angina, ST-segment elevation myocardial infarction (STEMI), Venous thromboembolism (VTE), Blood coagulation disorders Details
Fibrin sealant patch (Takeda) Approved Nycomed Pharmaceutical, Takeda human fibrinogen;human thrombin ema Takeda Austria GmbH 2004-06-08 Bleeding Details
Andexanet alfa PRT-064445; PRT-4445; PRT-44545,PRT064445,PRT4445 Approved Portola Pharmaceutical andexanet alfa ema

For adult patients treated with a direct factor Xa (FXa) inhibitor (apixaban or rivaroxaban) when reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding.

Portola Netherlands B.V. 2019-04-26 Hemorrhagic disorder Details
Enoxaparin sodium biosimilar (Harvest Moon Pharmaceuticals) Approved Harvest Moon Unstable angina, Deep vein thrombosis (DVT), Venous thromboembolism (VTE), Myocardial infarction (MI) Details
Enoxaparin sodium biosimilar (Chandra Bhagat Pharma) Approved Chandra Bhagat Pharma(CBC) Deep vein thrombosis (DVT) Details
Desirudin CGP-39393 Approved Unknown desirudin ema

Prevention of deep venous thrombosis in patients undergoing elective hip or knee replacement surgery.

Canyon Pharmaceuticals Ltd. 1997-07-09 Venous thromboembolism (VTE) Details
Human fibrinogen concentrate (LFB Biomedicaments) FGTW; FibCLOT Approved LFB Biotechnologies, Innsbruck Medical University FibCLOT hma Afibrinogenaemia, Blood coagulation disorders Laboratoire Francais du Fractionnement et des Biotechnologies
3 Avenue des Tropiques
ZA de Courtaboeuf
91940 Les Ulis, France
2015-12-22 Afibrinogenaemia, Blood coagulation disorders Details
Enoxaparin Sodium PK-10169; RP-54563; XRP-4563K; M-enoxaparin; PRY-005; RPY-005 Approved Sanofi LOVENOX (PRESERVATIVE FREE) fda SANOFI AVENTIS US 1993-03-29 Unstable angina, ST-segment elevation myocardial infarction (STEMI), Venous thromboembolism (VTE) Details
Human fibrin sealant kit (Hualan Biological Engineering) Approved Hualan Biological Engineering Human Fibrin Sealant Kit cfda wound, Bleeding 2015-05-26 wound, Bleeding Details
Bivalirudin BG-8967; Hirulog-1 Approved The Medicines Company ANGIOMAX fda Percutaneous coronary intervention (PCI), Unstable angina, Percutaneous transluminal coronary angioplasty (PTCA) SANDOZ INC 2000-12-15 Percutaneous coronary intervention (PCI), Thrombocytopenia, Percutaneous transluminal coronary angioplasty (PTCA), Thromboembolism Details
Liquid fibrin sealant (OMRIX Biopharmaceuticals) Approved OMRIX Biopharmaceuticals, Ethicon Quixil hma Bleeding Omrix Biopharmaceuticals S.A.
200 Chaussee de Waterloo
1640 Rhode St Genese
2000-12-07 Bleeding Details
Antithrombin III (Human, Grifols) Approved Grifols Hereditary antithrombin deficiency, Thromboembolism Details
Human coagulation factor X (Bio Products Laboratory) Approved Bio Products Laboratory Human coagulation factor X ema BPL Bioproducts Laboratory GmbH 2016-03-16 Factor X deficiency Details
Human fibrinogen/Human thrombin (Mallinckrodt) PRO-0601 Approved Mallinckrodt human fibrinogen;human thrombin ema Mallinckrodt Pharmaceuticals Ireland Limited 2015-03-19 Surgical blood loss Details
Enoxaparin sodium biosimilar (Blau Pharmaceuticals) Approved Blau Pharmaceuticals Thrombosis Details
Human prothrombin complex concentrate (Guizhou Taibang Biological Products) Approved Guizhou Taibang Biological Products Prothrombin complex deficiency Details
Prothrombin complex concentrate (Sanquin) Approved Sanquin Cofact hma Bleeding Sanquin
Plesmanlaan 125
1066 CX Amsterdam
The Netherlands
2006-11-19 Bleeding Details
Enoxaparin sodium biosimilar (Pharmathen) Approved Pharmathen enoxaparin sodium ema Pharmathen S.A. 2016-09-14 Unstable angina, Deep vein thrombosis (DVT), Venous thromboembolism (VTE), Myocardial infarction (MI) Details
Enoxaparin sodium biosimilar (PT Kalbe) Approved Kalbe Farma Unstable angina, Deep vein thrombosis (DVT), Myocardial infarction (MI) Details
Human prothrombin complex (Octapharma) Approved Octapharma Human prothrombin complex (Octapharma) 德国 Bleeding Octapharma 2003-03-14 00:00:00.0 Bleeding Details
Human prothrombin complex concentrate (Shanxi Kangbao Biological Products) Approved Shanxi Kangbao Biological Product Human Prothrombin Complex cfda Bleeding, Surgical blood loss 2019-09-17 Surgical blood loss, Bleeding Details
Enoxaparin sodium biosimilar (Rovi) Approved Rovi Unstable angina, Deep vein thrombosis (DVT), Myocardial infarction (MI) Details
Antithrombin alfa rhATIII Approved Genzyme, rEVO Biologics Antithrombin alfa ema Laboratoire Francais du Fractionnement et des Biotechnologies 2006-07-28 Hereditary antithrombin deficiency Details
Fibrinogen (Octapharma) Approved Octapharma Afibrinogenaemia Details
Prothrombin complex concentrat (Taibang Biological Products) Approved Shandong Taibang Biological Products Human Prothrombin Complex cfda Bleeding 2014-09-30 Bleeding Details
Human fibrinogen/Human thrombin (Baxalta) Approved Baxalta Bleeding Details
Idarucizumab BI-655075; 97RWB5S1U6 (UNII code) ,BI655075 Approved Boehringer Ingelheim PRAXBIND fda Emergency surgery, Bleeding BOEHRINGER INGELHEIM 2015-10-16 Emergency surgery, Bleeding Details
Enoxaparin sodium biosimilar (Neiss Labs) Approved Neiss Labs Deep vein thrombosis (DVT) Details
Dabigatran Etexilate Mesylate BIBR-1048MS; BIBR-953; BIBR-953-ZW; BIBR-1048,BIBR 1048 MS,BIBR1048 MS Approved Boehringer Ingelheim Dabigatran etexilate mesilate ema Boehringer Ingelheim International GmbH 2008-03-17 Pulmonary embolism, Deep vein thrombosis (DVT), Stroke and systemic embolism, Venous thromboembolism (VTE) Details

Coagulation Factor II Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
GH-9001 GH-9001 Phase Ⅰ InflaZyme, Leo Pharma Thrombosis Details
Efegatran sulfate hydrate GYKI-14766; LY-294468 Phase Ⅱ Lilly, Ivax Thrombosis, Myocardial infarction (MI) Details
VE-1902 VE-01902; VE-1902,VE 1902,VE1902 Phase Ⅰ Verseon Atrial fibrillation Details
Ximelagatran H-376/95; H-376; H-37695,H 376/95,H376/95 Withdrawn AstraZeneca Venous thromboembolism (VTE) Details
Recombinant Hirudin-2 (AMMS) IND Filing Institute of Pharmacology & Radiation of AMMS Unspecified Details
L-376062 L-372236; L-377009; L-376062; L-375378; L-373722; L-372460 Phase Ⅰ Merck Sharp & Dohme Thrombosis Details
TRI-50b TRI-50b; TRI-50; TRI-B50,TRI50b Phase Ⅱ Trigen Holdings AG Thrombosis Details
Napsagatran RO-466240; RO-46-6240/010 Phase Ⅱ Roche Thrombosis, Myocardial infarction (MI) Details
Flovagatran sodium TGN-255,TGN255 Phase Ⅱ Trigen Holdings AG Thrombosis Details
BCH-2763 BCH-2763 Preclinical Shire Thrombosis Details
Recombinant hirudin (Fosun Pharma) IND Filing Fosun Pharma Thrombosis Details
Sofigatran MCC-977 Phase Ⅱ Mitsubishi Tanabe Pharma Deep vein thrombosis (DVT) Details
DP-4088 DPOC-4088; DP-4088,DP4088,DPOC4088 Phase Ⅰ Merck Sharp & Dohme, Diakron, Orchid Blood coagulation disorders Details
Recombinant human thrombin (Suzhou Zelgen Biopharmaceutical) Phase Ⅲ Zelgen Biosciences Surgical blood loss Details
Recombinant bifunctional hirudin (Fudan University) Phase Ⅰ Fudan University Unspecified Details
CTB-001 CTB-001; CT-001 Phase Ⅰ C-TRI Thrombosis Details
Vasoflux Phase Ⅱ InflaZyme Myocardial infarction (MI), Thrombosis Details
LB-30057 CI-1028; LB-30057; PD-172524 Phase Ⅰ LG Chem, Pfizer Thrombosis Details
UK-156406 UK-156406 Phase Ⅰ Pfizer Thrombosis Details
GW-473178 GW-473178 Phase Ⅰ GlaxoSmithKline Venous thromboembolism (VTE), Atrial fibrillation Details
Enoxaparin sodium biosimilar (Techdow) BLA Filing Shenzhen Techdow Unstable angina, Deep vein thrombosis (DVT), Venous thromboembolism (VTE), Myocardial infarction (MI) Details
SR-123781 SR-123781; SR-123781A; SanOrg-123781; HDS; SANORG 123781A Phase Ⅲ Sanofi Acute coronary syndrome (ACS), Thrombosis Details
PF-05230907 PF-05230907; PF-5230907; PF-907 Phase Ⅰ Pfizer Cerebral haemorrhage Details
EP-217609 Org-217609; EP-217609; EP217609C101,Org217609; EP21796 Phase Ⅱ Merck Sharp & Dohme, Endotis Thrombosis Details
ORG-27306 ORG-27306 Phase Ⅰ Merck Sharp & Dohme Thrombosis Details
V-19 V-19 Phase Ⅱ InflaZyme Thrombosis Details
CX-397 CX-397,CX 397,CX397 Phase Ⅱ Kaken Pharmaceutical Disseminated intravascular coagulation (DIC), Thrombosis Details
TRIB-50 TRI-50; TRI-B50 Phase Ⅱ Thrombosis Research Institute, Trigen Holdings AG Thrombosis Details
Org-36764 Org-36764 Phase Ⅰ Merck Sharp & Dohme Thrombosis Details
Odiparcil SB-424323; IVA-336 Phase Ⅱ Abbvie, GlaxoSmithKline Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome) Details
Deligoparin sodium OP-2000 Phase Ⅲ Opocrin SpA, Aeolus Pharmaceuticals, Perrigo Cardiovascular disorders, Ulcerative colitis, Inflammatory bowel disease Details
Thrombomodulin (Mochida/JCR) MB-015; MR-33; TMD1-105; rhu-TM BLA Filing Mochida, JCR Pharmaceuticals Disseminated intravascular coagulation (DIC) Details
Peptide-based blood coagulant (Haemostatix) Phase Ⅱ Haemostatix, Boryung Pharmaceutical Surgical blood loss Details
BSF-208791 BSF 208791; BSF208791 Phase Ⅰ Abbvie Thrombosis Details
rHV2-Lys-47 rHV2-Lys-47 Phase Ⅰ Sanofi, Transgene Disseminated intravascular coagulation (DIC), Thrombosis Details
EGR-Xa EGR-Xa Phase Ⅰ COR Therapeutics Inc Thromboembolism Details
SSR-182289A SSR-182289A; SSR-182289,SSR182289A,SSR182289 Phase Ⅱ Sanofi Thrombosis Details
CVS-1578 CVS-1578 Phase Ⅰ Merck Sharp & Dohme, Dendreon Corporation Thromboembolism Details
SSR-128429 SSR-128429 Phase Ⅰ Sanofi Thromboembolism Details
Dabigatran etexilate tosylate (Huons) RDG-17012 Phase Ⅰ Huons Thromboembolism Details
Targeted NIF-hirulog hybrid (Chongqing Fujin Biomedical) rNIF-hirulog; TNHH Phase Ⅰ Chongqing Fujin Biomedical Stroke Details
Heparinase I Phase Ⅲ IBEX Technologies, BioMarin Pharmaceutical Blood coagulation disorders Details
Semuloparin sodium AVE-5026 NDA Filing Sanofi Thromboembolism Details
ARC-183 ARC-183 Phase Ⅰ Archemix Thrombosis Details
AZD-8165 AZD-8165 Phase Ⅰ AstraZeneca Thrombosis Details
Recombinant hirudin (Guangzhou Recomgen Biotech) IND Filing Guangzhou Recomgen Biotech Thrombosis Details
Recombinant hirudin (Shandong Ahua Biochemical) IND Filing Angde Biopharmaceutical Thrombosis Details
MPC-0920 MPC-0920 Phase Ⅰ Myriad Genetics Thrombosis Details
CVS-1123 CVS-1123 Phase Ⅰ Merck Sharp & Dohme Unstable angina, Coronary artery disease (CAD), Venous thromboembolism (VTE) Details
Recombinant hirudin (Kerun Biopharmaceutical) IND Filing Kerun Biopharmaceutical Thrombosis Details
EP-42675 Org-42675; EP-42675,EP42675,Org42675 Phase Ⅰ Merck Sharp & Dohme, Endotis Thrombosis Details
3DP-4815 3DP-4815; JNJ-6368661; RWJ-422521; TDP-4815 Phase Ⅰ Johnson & Johnson Arterial thrombosis, Venous thromboembolism (VTE) Details
Enoxaparin sodium biosimilar (Biocad) BCD-080 Phase Ⅲ Biocad Deep vein thrombosis (DVT), Venous thromboembolism (VTE) Details
Recombinant staphylokinase-hirudin fusion protein IND Filing Humanwell Healthcare, Institute of Pharmacology & Radiation of AMMS Thromboembolism Details
S-18326 S-18326 Phase Ⅰ Servier Thrombosis Details
NU-172 ARC-2172; NU-172 Phase Ⅱ Archemix, ARCA biopharma Heart disease Details
Ichorcumab JNJ-64179375; JNJ-9375; JNJ-375,JNJ64179375; JNJ9375; JNJ375,JNJ 64179375; JNJ 9375; JNJ 375 Phase Ⅱ Cambridge University Hospitals, University of Cambridge, Janssen Thrombosis Details
Inogatran Inogatran; H-314/27; HA-31427 Phase Ⅱ AstraZeneca Unstable angina, Myocardial infarction (MI) Details
EH Phase Ⅰ Academy of Military Medical Sciences, Beijing Sanyouliheze Biological Technology Deep vein thrombosis (DVT) Details
RWJ-27755 PPACK; RWJ-27755 Preclinical Johnson & Johnson Thrombosis Details
CJC-1004 CJC-1004; CCI-1004; DAC:T1 Phase Ⅱ ConjuChem Thrombosis Details
MER-102 Phase Ⅰ Merrion Pharmaceuticals Thrombosis Details
Adomiparin sodium M-118 Phase Ⅱ Momenta Acute coronary syndrome (ACS) Details

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