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Coagulation Factor II

Coagulation Factor II Molecule Information

Name:Prothrombin
Target Synonym:Thrombin light chain?Prothrombin?Thrombin heavy chain?Activation peptide fragment 2?F2?Activation peptide fragment 1?Coagulation factor II
Number of Launched Drugs:28
Number of Drugs in Clinical Trials:60
Lastest Research Phase:Approved

Coagulation Factor II Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
THN-H52H0 Human Human Coagulation Factor II / Thrombin Protein
THN-H52H0-structure
THN-H52H0-sds

Coagulation Factor II Molecule Synonym Name

thrombin,Coagulation factor II

Coagulation Factor II Molecule Background

Prothrombin is also known as coagulation factor II (F2),which can be cleaved into the following 4 chains: activation peptide fragment 1, activation peptide fragment 2, thrombin light chain and thrombin heavy chain. Coagulation factor II (F2) is able to form a heterodimer with SERPINA5. The mutations of F2 gene can result in a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. Furthermore, thrombin converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Coagulation factor II (F2) can also play an important role in blood homeostasis, inflammation and wound healing.

Coagulation Factor II References

Coagulation Factor II Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Human prothrombin complex (Tonrol Biopharmaceuticals) Approved Tonrol Factor X deficiency, Hemophilia B, Congenital factor VII deficiency, Bleeding Details
Thrombomodulin Alfa ART-123; TMD-123; AT-908,ART123 Approved Asahi Kasei Thrombomodulin Alfa 日本 Disseminated intravascular coagulation (DIC) 旭化成 2008-01-25 00:00:00.0 Disseminated intravascular coagulation (DIC) Details
Fibrin patch (Ethicon/Omrix Biopharmaceuticals) Approved Johnson & Johnson human fibrinogen / human thrombin ema

 Supportive treatment in adult surgery where standard surgical techniques are insufficient (see section 5.1):

-   for improvement of haemostasis.

Omrix Biopharmaceuticals N. V. 2013-09-25 Bleeding Details
Dermatan sulfate MF-701,MF-777 Approved Mediolanum Farmaceutici Dermatan sulfate 意大利 Thrombosis, Venous thromboembolism (VTE), Thrombocytopenia Mediolanum Farmaceutici 1998-07-01 00:00:00.0 Thrombocytopenia, Venous thromboembolism (VTE), Thrombosis Details
Argatroban DK-7419; GN1600; MCI-9038; MD-805; MDI-805; OM-805,MD-805,OM-805,DK-7419,MCI-9038,MQPA Approved Mitsubishi Tanabe Pharma, Pfizer Argatroban 日本 1990-01-01 00:00:00.0 Percutaneous coronary intervention (PCI), Thrombocytopenia Details
Human fibrinogen/Human thrombin (Instituto Grifols) Approved Grifols human fibrinogen;human thrombin ema Mallinckrodt Pharmaceuticals Ireland Limited 2015-03-19 Bleeding Details
Antithrombin Gamma KW-3357,KW3357 Approved Kyowa Hakko Kirin Antithrombin Gamma 日本 Hereditary antithrombin deficiency, Disseminated intravascular coagulation (DIC) 协和发酵麒麟 2015-07-03 00:00:00.0 Disseminated intravascular coagulation (DIC), Hereditary antithrombin deficiency Details
Antithrombin III (CSL Behring) BI51.017 Approved CSL Behring Antithrombin III (CSL Behring) 日本 Thrombosis, Disseminated intravascular coagulation (DIC) CSL Behring 1987-08-02 00:00:00.0 Disseminated intravascular coagulation (DIC), Thrombosis, Thrombosis Details
Human fibrinogen concentrate (CSL Behring) Approved CSL Behring Afibrinogenaemia Details
Fibrin sealant patch (Takeda) Approved Nycomed Pharmaceutical, Takeda human fibrinogen;human thrombin ema Takeda Austria GmbH 2004-06-08 Bleeding Details
Andexanet alfa PRT-064445; PRT-4445; PRT-44545,PRT064445,PRT4445 Approved Portola Pharmaceutical Hemorrhagic disorder Details
Enoxaparin sodium biosimilar (Harvest Moon Pharmaceuticals) Approved Harvest Moon Unstable angina, Deep vein thrombosis (DVT), Venous thromboembolism (VTE), Myocardial infarction (MI) Details
Desirudin CGP-39393; r-Hirudin Approved Unknown desirudin ema

Prevention of deep venous thrombosis in patients undergoing elective hip or knee replacement surgery.

Canyon Pharmaceuticals Ltd. 1997-07-09 Venous thromboembolism (VTE) Details
Human fibrinogen concentrate (LFB Biomedicaments) FGTW; FibCLOT Approved LFB Biotechnologies, Innsbruck Medical University Afibrinogenaemia, Blood coagulation disorders Details
Enoxaparin Sodium PK-10169; RP-54563; XRP-4563K; M-enoxaparin; PRY-005; RPY-005 Approved Sanofi LOVENOX (PRESERVATIVE FREE) fda SANOFI AVENTIS US 1993-03-29 Unstable angina, ST-segment elevation myocardial infarction (STEMI), Venous thromboembolism (VTE) Details
Bivalirudin BG-8967,BG8967,BG 8967 Approved The Medicines Company ANGIOMAX fda Unstable angina, Percutaneous transluminal coronary angioplasty (PTCA), Percutaneous coronary intervention (PCI) THE MEDICINES CO 2000-12-15 Percutaneous coronary intervention (PCI), Thrombocytopenia, Percutaneous transluminal coronary angioplasty (PTCA), Thromboembolism Details
Liquid fibrin sealant (OMRIX Biopharmaceuticals) Approved OMRIX Biopharmaceuticals, Ethicon human fibrinogen;human thrombin ema Omrix Biopharmaceuticals N. V. 2008-10-06 Bleeding Details
Antithrombin III (Human, Grifols) Approved Grifols Hereditary antithrombin deficiency, Thromboembolism Details
Human coagulation factor X (Bio Products Laboratory) Approved Bio Products Laboratory Human coagulation factor X ema

Coagadex is indicated for the treatment and prophylaxis of bleeding episodes and for perioperative management in patients with hereditary factor X deficiency.

Bio Products Laboratory Limited 2016-03-16 Factor X deficiency Details
Human fibrinogen/Human thrombin (Mallinckrodt) PRO-0601 Approved Mallinckrodt Surgical blood loss Details
Prothrombin complex concentrate (Sanquin) Approved Sanquin Bleeding Details
Human prothrombin complex (Octapharma) Approved Octapharma 德国 Bleeding Octapharma 2003-03-14 00:00:00.0 Bleeding Details
Enoxaparin sodium biosimilar (Rovi) Approved Rovi Unstable angina, Deep vein thrombosis (DVT), Myocardial infarction (MI) Details
Antithrombin alfa rhATIII Approved Genzyme, rEVO Biologics Antithrombin alfa ema Laboratoire Francais du Fractionnement et des Biotechnologies 2006-07-28 Hereditary antithrombin deficiency Details
Fibrinogen (Octapharma) Approved Octapharma Afibrinogenaemia Details
Prothrombin complex concentrat (Taibang Biological Products) Approved Shandong Taibang Biological Products Human Prothrombin Complex cfda Bleeding 2014-09-30 Bleeding Details
Idarucizumab BI-655075; 97RWB5S1U6 (UNII code) ,BI655075 Approved Boehringer Ingelheim PRAXBIND fda Emergency surgery, Bleeding BOEHRINGER INGELHEIM 2015-10-16 Emergency surgery, Bleeding Details
Dabigatran Etexilate Mesylate BIBR-1048MS; BIBR-953; BIBR-953-ZW; BIBR-1048,BIBR 1048 MS,BIBR1048 MS Approved Boehringer Ingelheim Dabigatran etexilate mesilate ema Boehringer Ingelheim International GmbH 2008-03-18 Pulmonary embolism, Deep vein thrombosis (DVT), Stroke and systemic embolism, Venous thromboembolism (VTE) Details

Coagulation Factor II Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
GH-9001 GH-9001 Phase Ⅰ InflaZyme, Leo Pharma Thrombosis Details
Efegatran sulfate hydrate GYKI-14766; LY-294468 Phase Ⅱ Lilly, Ivax Thrombosis, Myocardial infarction (MI) Details
VE-1902 VE-1902 Phase Ⅰ Verseon Cardiovascular disorders, Stroke, Acute coronary syndrome (ACS), Stroke in atrial fibrillation, Venous thromboembolism (VTE) Details
Ximelagatran H-376/95; H-376; H-37695,H 376/95,H376/95 Withdrawn AstraZeneca Venous thromboembolism (VTE) Details
Recombinant Hirudin-2 (AMMS) IND Filing Institute of Pharmacology & Radiation of AMMS Unspecified Details
L-376062 L-372236; L-377009; L-376062; L-375378; L-373722; L-372460 Phase Ⅰ Merck Sharp & Dohme Thrombosis Details
TRI-50b TRI-50b; TRI-50; TRI-B50,TRI50b Phase Ⅱ Trigen Holdings AG Thrombosis Details
Napsagatran RO-466240; RO-46-6240/010 Phase Ⅱ Roche Thrombosis, Myocardial infarction (MI) Details
Flovagatran sodium TGN-255,TGN255 Phase Ⅱ Trigen Holdings AG Thrombosis Details
BCH-2763 BCH-2763 Preclinical Shire Thrombosis Details
Sofigatran MCC-977 Phase Ⅱ Mitsubishi Tanabe Pharma Deep vein thrombosis (DVT) Details
DP-4088 DPOC-4088; DP-4088,DP4088,DPOC4088 Phase Ⅰ Merck Sharp & Dohme, Diakron, Orchid Blood coagulation disorders Details
Recombinant human thrombin (Suzhou Zelgen Biopharmaceutical) Phase Ⅱ Zelgen Biosciences Surgical blood loss Details
Recombinant bifunctional hirudin (Fudan University) Phase Ⅰ Fudan University Unspecified Details
CTB-001 CTB-001; CT-001,CTB-001 Phase Ⅰ C-TRI Thrombosis Details
Vasoflux Phase Ⅱ InflaZyme Myocardial infarction (MI), Thrombosis Details
LB-30057 CI-1028; LB-30057; PD-172524 Phase Ⅰ LG Chem, Pfizer Thrombosis Details
UK-156406 UK-156406 Phase Ⅰ Pfizer Thrombosis Details
GW-473178 GW-473178 Phase Ⅰ GlaxoSmithKline Venous thromboembolism (VTE), Atrial fibrillation Details
Enoxaparin sodium biosimilar (Techdow) Inhixa BLA Filing Shenzhen Techdow Unstable angina, Deep vein thrombosis (DVT), Venous thromboembolism (VTE), Myocardial infarction (MI) Details
SR-123781 SR-123781; SR-123781A; SanOrg-123781; HDS; SANORG 123781A Phase Ⅲ Sanofi Acute coronary syndrome (ACS), Thrombosis Details
PF-05230907 PF-05230907; PF-5230907; PF-907 Phase Ⅰ Pfizer Cerebral haemorrhage Details
CX-397 CX-397 Phase Ⅱ Kaken Pharmaceutical Disseminated intravascular coagulation (DIC), Thrombosis Details
Ichorcumab JNJ-64179375 Phase Ⅱ Janssen, Johnson & Johnson Thrombosis Details
EP-217609 Org-217609; EP-217609,Org217609,EP21796,EP217609C101 Phase Ⅱ Merck Sharp & Dohme, Endotis Thrombosis Details
ORG-27306 ORG-27306 Phase Ⅰ Merck Sharp & Dohme Thrombosis Details
V-19 V-19 Phase Ⅱ InflaZyme Thrombosis Details
TRIB-50 TRI-50; TRI-B50 Phase Ⅱ Thrombosis Research Institute, Trigen Holdings AG Thrombosis Details
Org-36764 Org-36764 Phase Ⅰ Merck Sharp & Dohme Thrombosis Details
Odiparcil 424323; SB-424323;IVA-336,SB424323 Phase Ⅱ Abbvie, GlaxoSmithKline Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome) Details
Deligoparin sodium OP-2000 Phase Ⅲ Opocrin SpA, Aeolus Pharmaceuticals, Perrigo Cardiovascular disorders, Ulcerative colitis, Inflammatory bowel disease Details
Thrombomodulin (Mochida/JCR) MB-015; MR-33; TMD1-105; rhu-TM BLA Filing Mochida, JCR Pharmaceuticals Disseminated intravascular coagulation (DIC) Details
Peptide-based blood coagulant (Haemostatix) Phase Ⅱ Haemostatix, Boryung Pharmaceutical Surgical blood loss Details
BSF-208791 BSF 208791; BSF208791 Phase Ⅰ Abbvie Thrombosis Details
rHV2-Lys-47 rHV2-Lys-47 Phase Ⅰ Sanofi, Transgene Disseminated intravascular coagulation (DIC), Thrombosis Details
SSR-182289A SSR-182289A; SSR-182289,SSR182289A,SSR182289 Phase Ⅱ Sanofi Thrombosis Details
CVS-1578 CVS-1578 Phase Ⅰ Merck Sharp & Dohme, Dendreon Corporation Thromboembolism Details
Enoxaparin sodium biosimilar (Pharmathen) Thorinane BLA Filing Pharmathen Unstable angina, Deep vein thrombosis (DVT), Venous thromboembolism (VTE), Myocardial infarction (MI) Details
Targeted NIF-hirulog hybrid (Chongqing Fujin Biomedical) Phase Ⅰ Chongqing Fujin Biomedical Cerebrovascular diseases Details
Neutrophil inhibitory factor-hirulog hybrid rNIF-hirulog; TNHH Phase Ⅰ Chongqing Fagen Biopharmaceutical, West China Hospital Sichuan University Stroke Details
Heparinase I Phase Ⅲ IBEX Technologies, BioMarin Pharmaceutical Blood coagulation disorders Details
Octaparin; Semuloparin sodium AVE-5026 NDA Filing Sanofi Thromboembolism Details
ARC-183 ARC-183 Phase Ⅰ Archemix Thrombosis Details
AZD-8165 AZD-8165 Phase Ⅰ AstraZeneca Thrombosis Details
Human prothrombin complex concentrate (Shanxi Kangbao Biological Products) Phase Not Specified Shanxi Kangbao Biological Product Surgical blood loss, Bleeding Details
MPC-0920 MPC-0920 Phase Ⅰ Myriad Genetics Thrombosis Details
CVS-1123 CVS-1123 Phase Ⅰ Merck Sharp & Dohme Unstable angina, Coronary artery disease (CAD), Venous thromboembolism (VTE) Details
Recombinant hirudin (Kerun Biopharmaceutical) Phase Ⅰ Kerun Biopharmaceutical Thrombosis Details
EP-42675 Org-42675; EP-42675,EP42675,Org42675 Phase Ⅰ Merck Sharp & Dohme, Endotis Thrombosis Details
3DP-4815 3DP-4815; JNJ-6368661; RWJ-422521; TDP-4815 Phase Ⅰ Johnson & Johnson Arterial thrombosis, Venous thromboembolism (VTE) Details
Enoxaparin sodium biosimilar (Biocad) BCD-080 Phase Ⅲ Biocad Deep vein thrombosis (DVT), Venous thromboembolism (VTE) Details
Recombinant staphylokinase-hirudin fusion protein IND Filing Humanwell Healthcare, Institute of Pharmacology & Radiation of AMMS Thromboembolism Details
S-18326 S-18326 Phase Ⅰ Servier Thrombosis Details
NU-172 ARC-2172; NU-172 Phase Ⅰ Archemix, ARCA biopharma Thrombosis Details
Inogatran Inogatran; H-314/27; HA-31427 Phase Ⅱ AstraZeneca Unstable angina, Myocardial infarction (MI) Details
EH Phase Ⅰ AMMS, Beijing Sanyouliheze Biological Technology Deep vein thrombosis (DVT) Details
RWJ-27755 PPACK; RWJ-27755 Preclinical Johnson & Johnson Thrombosis Details
CJC-1004 CJC-1004; CCI-1004; DAC:T1 Phase Ⅱ ConjuChem Thrombosis Details
MER-102 Phase Ⅰ Merrion Pharmaceuticals Thrombosis Details
Adomiparin sodium M-118 Phase Ⅱ Momenta Acute coronary syndrome (ACS) Details

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