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Your Position: Home > Coagulation Factor II

Coagulation Factor II

Brief Information

Name:Prothrombin
Target Synonym:EC 3.4.21,Coagulation Factor II, Thrombin,Coagulation Factor II (Thrombin),Thrombin Factor II,Prothrombin B-Chain,Prothrombin,EC:3.4.21.5,Coagulation Factor II,THPH1,RPRGL2,Prepro-Coagulation Factor II,F2,Serine Protease,EC 3.4.21.5,PT
Number of Launched Drugs:46
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
THN-H52H0 Human Human Coagulation Factor II / Thrombin Protein, His Tag
THN-H52H0-structure

Synonym Name

thrombin,Coagulation factor II

Background

Prothrombin is also known as coagulation factor II (F2),which can be cleaved into the following 4 chains: activation peptide fragment 1, activation peptide fragment 2, thrombin light chain and thrombin heavy chain. Coagulation factor II (F2) is able to form a heterodimer with SERPINA5. The mutations of F2 gene can result in a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. Furthermore, thrombin converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Coagulation factor II (F2) can also play an important role in blood homeostasis, inflammation and wound healing.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Enoxaparin sodium biosimilar (Gland Pharma) Approved Gland Pharma Ltd Cutenox Angina, Unstable; Myocardial Infarction; Venous Thromboembolism; Venous Thrombosis Gland Pharma 2014-10-01 Angina, Unstable; Myocardial Infarction; Venous Thromboembolism; Venous Thrombosis Details
Hirudin biosimilar (Rhein-Minapharm) Approved Rhein Minapharm Biogenetics Thrombexx Egypt Venous Thrombosis Rhein Minapharm Biogenetics 2006-10-01 Venous Thrombosis Details
Enoxaparin sodium biosimilar (Harvest Moon Pharmaceuticals) Approved Harvest Moon Angina, Unstable; Myocardial Infarction; Venous Thromboembolism; Venous Thrombosis Details
Enoxaparin sodium biosimilar (PT Kalbe) Approved Kalbe Farma Kalbenox Cambodia Angina, Unstable; Myocardial Infarction; Venous Thrombosis Kalbe Farma 2012-01-01 Angina, Unstable; Myocardial Infarction; Venous Thrombosis Details
Argatroban GN1600; MD-805; OM-805; DK-7419; MDI-805; MCI-9038 Approved Pfizer Pharmaceuticals Ltd (China), Mitsubishi Tanabe Pharma Corp Acova, Argatra, Exembol, Slonnon, Novastan, Argatroban EU Thrombosis Mitsubishi Tanabe Pharma Gmbh 1990-01-23 Thrombocytopenia; Thrombosis Details
Enoxaparin sodium biosimilar (Blau Pharmaceuticals) Approved Blau Pharmaceuticals Enoxalow Thrombosis Blau Pharmaceuticals 2013-07-01 Thrombosis Details
Enoxaparin sodium biosimilar (Chandra Bhagat Pharma) Approved Chandra Bhagat Pharma(Cbc) MAXIPARINE Venous Thrombosis Details
Human Antithrombin III (Hemarus Therapeutics) Approved Hemarus Therapeutics India Antithrombin III Deficiency Hemarus Therapeutics 2015-08-01 Antithrombin III Deficiency Details
Enoxaparin sodium biosimilar (Sahar International Trading) Approved Sahar International Trading Angina, Unstable; ST Elevation Myocardial Infarction; Venous Thromboembolism; Blood Coagulation Disorders Sahar International Trading 2013-07-01 Blood Coagulation Disorders; Angina, Unstable; ST Elevation Myocardial Infarction; Venous Thromboembolism Details
Enoxaparin sodium biosimilar (Neiss Labs) Approved Neiss Labs Lomonox India Venous Thrombosis Neiss Labs 2012-08-01 Venous Thrombosis Details
Enoxaparin sodium biosimilar (Rovi) Approved Rovi Arovi Angina, Unstable; Myocardial Infarction; Venous Thrombosis Rovi 2018-03-31 Angina, Unstable; Myocardial Infarction; Venous Thrombosis Details
Dermatan sulfate MF-701; MF-777 Approved Mediolanum Farmaceutici Mistral Italy Venous Thromboembolism; Thrombosis; Thrombocytopenia Mediolanum Farmaceutici 1998-07-01 Venous Thromboembolism; Thrombocytopenia; Thrombosis Details
Heparin sodium biosimilar (Blau Pharmaceuticals) Approved Blau Pharmaceuticals Hepamax-S Brazil Thrombosis Blau Pharmaceuticals 2012-08-01 Thrombosis Details
Heparin sodium biosimilar (Chandra Bhagat Pharma) Approved Chandra Bhagat Pharma(Cbc) Thromboparin India Thrombosis Chandra Bhagat Pharma(Cbc) 2012-08-01 Thrombosis Details
Antithrombin III (Human, Grifols) Approved Grifols Sa Thrombate III United States Thromboembolism; Antithrombin III Deficiency null 1991-12-30 Antithrombin III Deficiency; Thromboembolism Details
Human coagulation factor X (Bio Products Laboratory) Approved Bio Products Laboratory Ltd Coagadex EU Factor X Deficiency Bpl Bioproducts Laboratory Gmbh 2015-10-20 Factor X Deficiency Details
Human fibrinogen/Human thrombin (Baxalta) Approved Baxalta Tisseel United States Hemorrhage null 1998-05-01 Seizures; Cerebrospinal Fluid Leak; Hemorrhage Details
Danaparoid sodium KB-101; Org-10172 Approved Merck Sharp & Dohme Corp, Organon Orgaran, Lomoparan Japan Venous Thromboembolism; Thrombocytopenia Rubin Ltd 1991-01-01 Venous Thromboembolism; Venous Thrombosis; Thrombocytopenia Details
Andexanet alfa PRT-4445; PRT-44545; PRT-064445 Approved Portola Pharmaceuticals Inc Ondexxya, Andexxa, Annexa-A, Annexa-R EU Drug-Related Side Effects and Adverse Reactions Alexion Europe Sas 2018-05-03 Hemorrhagic Disorders; Drug-Related Side Effects and Adverse Reactions; Hemorrhage Details
Antithrombin III (CSL Behring) BI51.017 Approved Csl Behring Llc Kybernin, Anthrobin, Athimbin Japan Thrombosis; Disseminated Intravascular Coagulation Csl Behring Llc 1987-08-02 Disseminated Intravascular Coagulation; Thrombosis Details
Polysulfonic mucopolysaccharide M-118102; M-7040B; M-1180B Approved Japan Arthritis; Cicatrix; Chilblains; Thrombophlebitis Maruho Co Ltd 1954-10-01 Thrombophlebitis; Cicatrix; Chilblains; Arthritis Details
Ardeparin sodium Approved Wyeth-Ayerst Normiflo United States Pulmonary Embolism; Venous Thrombosis null 1997-05-01 Pulmonary Embolism; Venous Thrombosis Details
Parnaparin sodium OP-2123; CB-01-05 Approved Opocrin Spa, Alfasigma Fluxum, Lowhepa, Minidalton Portugal Thrombosis Alfasigma Usa Inc 1993-01-01 Thrombosis Details
Idarucizumab BI-655075; 97RWB5S1U6 (UNII code) Approved Boehringer Ingelheim Gmbh 泰毕安, Praxbind, Prizbind Mainland China Hemorrhage Boehringer Ingelheim International Gmbh 2015-10-16 Hemorrhage Details
Dalteparin Sodium FR-860; KV-165; KABI-2165 Approved Pfizer Pharmaceuticals Ltd (China) 法安明, Fragmin Mainland China Coronary Artery Disease; Thrombosis null 1985-01-01 Diabetic Foot; Venous Thromboembolism; Coronary Artery Disease; Thrombosis; Kidney Failure, Chronic Details
Bivalirudin BG-8967; Hirulog-1 Approved The Medicines Company Angiox, Kangio, Angiomax, Hirulog (former TM) United States Thrombosis Maia Pharms Inc 2000-12-15 ST Elevation Myocardial Infarction; Angina, Unstable; Myocardial Infarction; Heart Diseases; Acute Coronary Syndrome; Thromboembolism; Acute Disease; Hemorrhage; Thrombocytopenia; Thrombosis Details
Fondaparinux Sodium GSK-576428; Org-31540; SR-90107; SR-90107A Approved Organon Arixtra, Quixidar, 安卓 Japan Pulmonary Embolism Glaxosmithkline Plc 2001-12-07 Pulmonary Embolism; Angina, Unstable; Myocardial Infarction; Venous Thromboembolism; Liver Diseases; Thromboembolism; Angina Pectoris; Coronary Disease; Atrial Fibrillation; Venous Thrombosis Details
Certoparin sodium Approved Novartis Pharma Ag Troparin, Alphaparin, Sandoparin, Sandoparine, Mono-Embolex Switzerland, Austria, India Thromboembolism; Pulmonary Embolism; Venous Thrombosis Aspen 1997-01-01 Embolism; Pulmonary Embolism; Renal Insufficiency; Thromboembolism; Uremia; Atrial Fibrillation; Venous Thrombosis; Kidney Failure, Chronic Details
Dabigatran Etexilate Mesylate BIBR-953-ZW; BIBR-1048; BIBR-953; WD-1602; BIBR-1048MS Approved C.H. Boehringer Sohn Ag & Co. Kg Pradaxa, Prazaxa, 泰毕全, Pradax, Rendix Mainland China Stroke; Embolism Boehringer Ingelheim International Gmbh 2008-03-17 Embolism; Pulmonary Embolism; Venous Thromboembolism; Renal Insufficiency; Heart Valve Diseases; Stroke; Thromboembolism; Coronary Disease; Atrial Fibrillation; Hepatic Insufficiency; Venous Thrombosis; Renal Insufficiency, Chronic; Kidney Failure, Chronic Details
Enoxaparin Sodium PRY-005; RPY-005; PK-10169; RP-54563; XRP-4563K; M-enoxaparin Approved Sanofi 克赛, Clexane, Klexane, Lovenox, Enoxamed EU Venous Thromboembolism Techdow Pharma Netherlands Bv 1993-03-29 Myocardial Ischemia; Myocardial Infarction; ST Elevation Myocardial Infarction; Angina, Unstable; Abdominal Neoplasms; Venous Thromboembolism; Kidney Diseases; Hip Fractures; Venous Thrombosis; Thrombosis Details
Liquid fibrin sealant (OMRIX Biopharmaceuticals) Approved Omrix Biopharmaceuticals Evicel, Quixil United States Hemorrhage null 2003-03-21 Cerebrospinal Fluid Leak; Hemorrhage Details
Fibrin sealant patch (Takeda) Approved Nycomed Pharmaceutical TachoSil, TachoComb EU Hemorrhage Takeda Austria Gmbh 2004-06-08 Hemorrhage; Liver Diseases; Lung Diseases; Intraoperative Complications Details
Fibrin patch (Ethicon/Omrix Biopharmaceuticals) Approved Johnson & Johnson Evarrest United States Hemorrhage null 2012-12-05 Peripheral Vascular Diseases; Gastrointestinal Diseases; Hemorrhage; Cardiovascular Diseases; Blood Loss, Surgical Details
Antithrombin III (Octapharma Ab) Approved Octapharma Ab Atenativ EU Antithrombin III Deficiency Octapharma Ab 2007-12-20 Antithrombin III Deficiency Details
Antithrombin Gamma KW-3357 Approved Kyowa Hakko Kirin Co Ltd Acoalan Japan Antithrombin III Deficiency; Disseminated Intravascular Coagulation Kyowa Hakko Kirin Co Ltd 2015-07-03 Disseminated Intravascular Coagulation; Antithrombin III Deficiency; Pre-Eclampsia Details
Fibrinogen (Octapharma) Approved Octapharma Fibryga, Fibryna United States Afibrinogenemia null 2017-06-07 Afibrinogenemia Details
Prothrombin complex concentrat (Taibang Biological Products) Approved Shandong Taibang Biological Products Co Ltd Mainland China Hemorrhage Shandong Taibang Biological Products Co Ltd 2014-09-30 Hemorrhage; Antithrombin III Deficiency Details
Human prothrombin complex (Hualan Biological Engineering) Approved Hualan Genetic Engineering Co Ltd Mainland China Blood Coagulation Disorders null 1999-01-01 Blood Coagulation Disorders; Hemophilia B; Factor X Deficiency Details
Prothrombin complex concentrate (Sanquin) Approved Sanquin Plasma Products Bv Cofact Hemorrhage Sanquin Plasma Products Bv 2007-11-01 Hemorrhage Details
Factor IX complex (Grifols) Approved Grifols Sa Profilnine United States Hemophilia B null 1981-07-21 Hemophilia B Details
Human prothrombin complex (LFB) Approved Lfb Biotechnologies KANOKAD France Hemorrhage Lfb Biotechnologies 2008-09-01 Hemorrhage Details
Human prothrombin complex (CSL Behring) BE-1116 Approved Csl Behring Llc Kcentra, Beriplex, Confidex Coagulation Protein Disorders; Blood Coagulation Disorders; Hemorrhage; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Details
Human prothrombin complex concentrate (Guizhou Taibang Biological Products) Approved Guizhou Taibang Biological Products Co Ltd Mainland China Hypoprothrombinemias Guizhou Taibang Biological Products Co Ltd 2013-07-31 Hypoprothrombinemias Details
Prothrombinex-VF (CSL Behring) Approved Csl Behring Llc Australia Hemorrhage Csl Behring Llc 2014-10-01 Hemorrhage Details
Human prothrombin complex concentrate (Shanxi Kangbao Biological Products) Approved Shanxi Kangbao Biological Product Co Ltd Mainland China Hemorrhage Shanxi Kangbao Biological Product Co Ltd 2019-09-17 Hemorrhage Details
Human prothrombin complex (Shanghai Xinxing) Approved Shanghai Xinxing Medicine Co Ltd Mainland China Hemorrhage Shanghai Xinxing Medicine Co Ltd 1997-01-01 Hemorrhage Details
Human prothrombin complex (Sinopharm Shanghai Plasma) Approved Sinopharm Shanghai Plasma-Derived Biotherapies Co Ltd Mainland China Hemorrhage Sinopharm Shanghai Plasma-Derived Biotherapies Co Ltd 1997-01-01 Hemorrhage Details
Human prothrombin complex (Boya Bio-Pharmaceutical) Approved Boya Bio-Pharmaceutical Group Co Ltd Mainland China Hemorrhage Boya Bio-Pharmaceutical Group Co Ltd 2020-12-02 Hemorrhage Details
Human prothrombin complex (Guangdong Wellen) Approved Guangdong Wellen Pharmaceutical Co Ltd Mainland China Hemorrhage Guangdong Wellen Pharmaceutical Co Ltd 2020-10-21 Hemorrhage Details
Glucosamine Hydrochloride/Dermatan sulfate Approved Details
Dabigatran etexilate Approved Boehringer Ingelheim Pharmaceuticals Inc, Chengdu Easton Biopharmaceuticals Co Ltd, Tolife - Produtos Farmacêuticos Sa Italy Venous Thromboembolism Tolife - Produtos Farmacêuticos Sa 2021-06-21 Venous Thromboembolism; Stroke Details
Thrombomodulin Alfa ART-123; TMD-123; AT-908 Approved Asahi Kasei Corp Recomodulin Japan Disseminated Intravascular Coagulation Asahi Kasei Corp 2008-01-25 Disseminated Intravascular Coagulation; Blood Coagulation Disorders; Peripheral Nervous System Diseases; Sepsis; Idiopathic Pulmonary Fibrosis; Colonic Neoplasms Details
Human prothrombin complex (Tonrol Biopharmaceuticals) Approved Tonrol Bio-Pharmaceutical Co Ltd ProthoRAAS Mainland China Hemorrhage Shanghai Raas Blood Products Co Ltd 1996-01-01 Hemophilia B; Hemorrhage Details
Anti-inhibitor coagulant complex (Baxalta) Approved Baxalta Feiba, Prothromplex TOTAL Japan Hemophilia A; Hemophilia B Baxalta 1979-12-21 Hemophilia A; Blood Coagulation Disorders, Inherited; Hemophilia B Details
Human prothrombin complex (Octapharma) Approved Octapharma Ocplex, Octaplex, Pronativ United Kingdom Hemorrhage Octapharma 2003-03-14 Hemorrhage; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Enoxaparin sodium biosimilar (Biocad) BCD-080 Phase 3 Clinical Biocad Venous Thromboembolism; Venous Thrombosis Details
VE-1902 VE-1902; VE-01902 Phase 1 Clinical Verseon Atrial Fibrillation Details
Peptide-based blood coagulant (Haemostatix) Phase 2 Clinical Haemostatix Hemorrhage; Blood Loss, Surgical Details
NU-172 NU-172; ARC-2172 Phase 2 Clinical Archemix Heart Diseases Details
Ichorcumab JNJ-375; JNJ-9375; JNJ-64179375 Phase 2 Clinical University Of Cambridge, Cambridge University Hospitals Venous Thromboembolism; Thrombosis Details
Dabigatran etexilate tosylate (Huons) RDG-17012 Phase 1 Clinical Huons Thromboembolism Details
Recombinant human thrombin (Suzhou Zelgen Biopharmaceutical) Phase 3 Clinical Suzhou Zelgen Biosciences Co Ltd Hemorrhage; Blood Loss, Surgical Details
Odiparcil IVA-336; SB-424323 Phase 2 Clinical Abbvie Inc Pulmonary Embolism; Venous Thromboembolism; Atrial Fibrillation; Mucopolysaccharidosis VI; Venous Thrombosis Details
Human prothrombin complex concentrate (Harbin Shiheng Bioengineering Pharmaceutical) Phase 3 Clinical Harbin Pacific Biopharmaceutical Co Ltd Hemophilia B Details
Human prothrombin complex concentrate (Sichuan Yuanda Shuyang Pharmaceutical) Phase 3 Clinical Sichuan Yuanda Shuyang Pharmaceutical Co Ltd Blood Coagulation Disorders Details
Human prothrombin complex (Lanzhou Lansheng Blood Products) Phase 3 Clinical Lanzhou Lansheng Blood Products Co Ltd Hemophilia B Details
CTB-001 CT-001; CTB-001 Phase 2 Clinical C-Tri Anesthesia; Thrombosis Details
EH Phase 1 Clinical Beijing Sh Biotechnology Co Ltd, Chinese Academy Of Military Medical Sciences Venous Thrombosis Details
SAR107375E SAR-107375E Phase 1 Clinical Sanofi Venous Thromboembolism; Venous Thrombosis Details

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