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Your Position: Home > Coagulation Factor II

Coagulation Factor II

Brief Information

Target Synonym:Prothrombin,EC:,THPH1,Coagulation Factor II,Prepro-Coagulation Factor II,F2,Serine Protease,EC,PT,RPRGL2,EC 3.4.21,Coagulation Factor II, Thrombin,Coagulation Factor II (Thrombin),Thrombin Factor II,Prothrombin B-Chain
Number of Launched Drugs:55
Number of Drugs in Clinical Trials:15
Lastest Research Phase:Approved
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Synonym Name

thrombin,Coagulation factor II


Prothrombin is also known as coagulation factor II (F2),which can be cleaved into the following 4 chains: activation peptide fragment 1, activation peptide fragment 2, thrombin light chain and thrombin heavy chain. Coagulation factor II (F2) is able to form a heterodimer with SERPINA5. The mutations of F2 gene can result in a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. Furthermore, thrombin converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Coagulation factor II (F2) can also play an important role in blood homeostasis, inflammation and wound healing.

Clinical and Translational Updates

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