0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Activin RIB

Activin RIB

Activin RIB Molecule Information

Name:Transforming growth factor beta receptor 1
Target Synonym:EC 2.7.11,TbetaR-I,TGF-beta type I receptor,Serine/threonine-protein kinase receptor R4,TGFBR1,Activin A receptor type II-like protein kinase of 53kD,Transforming Growth Factor Beta Receptor 1,Transforming Growth Factor-Beta Receptor Type I,Activin A Rece
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 3 Clinical

Activin RIB Protein Product ListCompare or Buy

By Product Status:
By Product Category:
By Species:
By Tag:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
ACB-H52H4 Human Human Activin RIB / ACVR1B Protein, His Tag
ACB-H52H4-structure
ACB-H52H4-sds

Activin RIB Part of Bioactivity data

ACB-H52H4-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human TDGF1, Fc Tag on Protein A Biosensor, can bind Human Activin RIB, His Tag (Cat. No. ACB-H52H4) with an affinity constant of 5.6 μM as determined in BLI assay (ForteBio Octet Red96e) (QC Tested).

Activin RIB Molecule Synonym Name

ACVR1b,ALK4,ACVRLK4,ACTR-IB,SKR2

Activin RIB Molecule Background

Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is “ATP + [receptor-protein] = ADP + [receptor-protein] phosphate”. ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1.

Activin RIB References

Activin RIB Related Molecule

Activin RIB Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AVID-200 AVID-200 Phase 1 Clinical Formation Biologics Neoplasms; Scleroderma, Systemic; Primary Myelofibrosis; Scleroderma, Diffuse Details
PF-06952229 Phase 1 Clinical Pfizer Inc Liver Neoplasms; Carcinoma, Renal Cell; Neoplasms, Squamous Cell; Pancreatic Neoplasms; Mesothelioma; Breast Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Melanoma Details
TRK-250 TRK-250; BNC-1021 Phase 1 Clinical Bonac Corp Idiopathic Pulmonary Fibrosis Details
GFH-018 GFH018; GFH-018 Phase 1 Clinical Genfleet Therapeutics (Shanghai) Inc Liver Neoplasms; Solid tumours; Pancreatic Neoplasms; Carcinoma, Transitional Cell Details
Galunisertib LY-2157299 Phase 3 Clinical Eli Lilly And Company Solid tumours; Liver Neoplasms; Myelodysplastic Syndromes; Glioblastoma; Pancreatic Neoplasms; Glioma; Carcinoma, Hepatocellular; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details

This web search service is supported by Google Inc.

totop