Name:Transforming growth factor beta receptor 1 Target Synonym:EC 2.7.11,TbetaR-I,TGF-beta type I receptor,Serine/threonine-protein kinase receptor R4,TGFBR1,Activin A receptor type II-like protein kinase of 53kD,Transforming Growth Factor Beta Receptor 1,Transforming Growth Factor-Beta Receptor Type I,Activin A Rece
Number of Launched Drugs:0 Number of Drugs in Clinical Trials:5 Lastest Research Phase:Phase 3 Clinical
Loaded Human TDGF1, Fc Tag on Protein A Biosensor, can bind Human Activin RIB, His Tag (Cat. No. ACB-H52H4) with an affinity constant of 5.6 μM as determined in BLI assay (ForteBio Octet Red96e) (QC Tested).
Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is “ATP + [receptor-protein] = ADP + [receptor-protein] phosphate”. ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1.