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Activin RIB

Brief Information

Name:Transforming growth factor beta receptor 1
Target Synonym:EC 2.7.11,TbetaR-I,TGF-beta type I receptor,Serine/threonine-protein kinase receptor R4,TGFBR1,Activin A receptor type II-like protein kinase of 53kD,Transforming Growth Factor Beta Receptor 1,Transforming Growth Factor-Beta Receptor Type I,Activin A Rece
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
ACB-H52H4 Human Human Activin RIB / ACVR1B Protein, His Tag

Part of Bioactivity data


Loaded Human TDGF1, Fc Tag on Protein A Biosensor, can bind Human Activin RIB, His Tag (Cat. No. ACB-H52H4) with an affinity constant of 5.6 μM as determined in BLI assay (ForteBio Octet Red96e) (QC Tested).

Synonym Name



Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is “ATP + [receptor-protein] = ADP + [receptor-protein] phosphate”. ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PF-06952229 Phase 1 Clinical Pfizer Inc Liver Neoplasms; Carcinoma, Renal Cell; Neoplasms, Squamous Cell; Pancreatic Neoplasms; Mesothelioma; Breast Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Melanoma Details
TRK-250 TRK-250; BNC-1021 Phase 1 Clinical Bonac Corp Idiopathic Pulmonary Fibrosis Details
Galunisertib LY-2157299 Phase 3 Clinical Eli Lilly And Company Solid tumours; Liver Neoplasms; Myelodysplastic Syndromes; Glioblastoma; Pancreatic Neoplasms; Glioma; Carcinoma, Hepatocellular; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
FBM-5712 FBM-5712 Details
AVID-200 AVID-200 Phase 1 Clinical Formation Biologics Solid tumours; Scleroderma, Systemic; Primary Myelofibrosis; Scleroderma, Diffuse Details
GF-101 GFH018; GFH-018; GF-101 Phase 2 Clinical Genfleet Therapeutics (Shanghai) Inc Solid tumours; Liver Neoplasms; Carcinoma, Transitional Cell; Pancreatic Neoplasms Details

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