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Your Position: Home > TRAIL R2


Brief Information

Name:Tumor necrosis factor receptor superfamily member 10B
Target Synonym:Tumor necrosis factor receptor superfamily member 10B,CD262,DR5,KILLER,TRAILR2,Death receptor 5,TRAIL-R2,UNQ160/PRO186,TNFRSF10B,TNF Receptor Superfamily Member 10b,TNF-Related Apoptosis-Inducing Ligand Receptor 2,TRICK2,ZTNFR9,P53-Regulated DNA Damage-Inducible Cell Death Receptor(Killer),Tumor Necrosis Factor Receptor-Like Protein ZTNFR9,Death Domain Containing Receptor For TRAIL/Apo-2L,Apoptosis Inducing Protein TRICK2A/2B,Apoptosis Inducing Receptor TRAIL-R2,Cytotoxic TRAIL Receptor-2,Fas-Li
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:11
Lastest Research Phase:NDA/BLA

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Part of Bioactivity data


Loaded Human TRAIL R2, Fc Tag (Cat. No. TR2-H5255) on AHC Biosensor, can bind Human TRAIL, His Tag with an affinity constant of 0.146 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Mouse TRAIL R2, His TagMouse TRAIL R2, His Tag (Cat. No. TR2-M52H5) ELISA bioactivity

Immobilized Human TNFSF10 at 2 μg/mL (100 μL/well) can bind Mouse TRAIL R2, His Tag (Cat. No. TR2-M52H5) with a linear range of 0.039-0.625 μg/mL (QC tested).

Synonym Name



Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain.  TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Oba-01 Oba-01; Oba01 Phase 1 Clinical Yantai Heyuanaidisi Biomedical Technology Co Ltd Carcinoma, Non-Small-Cell Lung Details
Recombinant human tumor necrosis factor-related apoptosis-inducing ligand (Shenzhen Xinpeng Biotech) Phase 3 Clinical Shenzhen Sinobioway Xinpeng Biomedicine Co Ltd Neoplasms Details
Recombinant anti-human DR5 monoclonal antibody (Lonn Ryonn Pharma) CTB-006 Phase 1 Clinical Beijing Tongwei Shidai Shengwu Jishu Youxian Gongsi, Lonn Ryonn Pharma Ltd Solid tumours Details
FAP-DR5 RG-7386; RO-6874813 Millennium Pharmaceuticals Inc, F. Hoffmann-La Roche Ltd Details
TAS-266 TAS-266 Novartis Pharma Ag, Ablynx Details
IGM-8444 Igm Biosciences Inc Details
DS-8273 DS-8273; DS-8273a Daiichi Sankyo Co Ltd Details
Conatumumab AMG-655 Amgen Inc Details
BI-905711 BI-905711 Phase 1 Clinical Boehringer Ingelheim Gmbh Gastrointestinal Neoplasms Details
Dulanermin AMG-951; PRO-1762 Amgen Inc Details
Drozitumab R-7425; RG-7425; PRO-95780 Genentech Inc Details
Tigatuzumab TRA-8; CS-1008; IgG1-kappa Daiichi Sankyo Co Ltd, University Of Alabama At Birmingham Details
Benufutamab iDD-004; GEN-1029; Hx-DR5-01; Hx-DR5-05 Idd Biotech Details
Dulanermin (Shanghai GeBaiDe) Phase 3 Clinical Shanghai Gebaide Biotechnology Co Ltd Carcinoma, Non-Small-Cell Lung Details
Rilunermin alfa SCB-313 (TRAIL-Trimer) Phase 1 Clinical Sichuan Sanyecao Bio-Pharmaceutical Co Ltd Hydrothorax; Ascites; Peritoneal Neoplasms; Pleural Effusion, Malignant Details
INBRX-109 JCT-205; INBRX-109 Phase 1 Clinical Inhibrx Adenocarcinoma Details
Anti-DR5 CAR-T cell therapy (Shenzhen BinDeBio) Phase 2 Clinical Dehe Biotech Co Ltd Esophageal Neoplasms; Stomach Neoplasms; Glioma; Carcinoma, Hepatocellular Details

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