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Your Position: Home > TRAIL R2

TRAIL R2

TRAIL R2 Protein Product ListCompare or Buy

Product> Filter Results

Cat. No.	Species	Product Description
TR2-C52H7	Cynomolgus	Cynomolgus TRAIL R2 / DR5 / TNFRSF10B Protein, His Tag
TR2-M52H5	Mouse	Mouse TRAIL R2 / DR5 / TNFRSF10B Protein, His Tag
TR2-H82E6	Human	Biotinylated Human TRAIL R2 / DR5 / TNFRSF10B Protein, Avitag™,His Tag
TR2-H5255	Human	Human TRAIL R2 / DR5 / TNFRSF10B Protein, Fc Tag
TR2-H5229	Human	Human TRAIL R2 / DR5 / TNFRSF10B Protein, His Tag

TRAIL R2 Part of Bioactivity data

TR2-H5255-BLI

Loaded Human TRAIL R2, Fc Tag (Cat. No. TR2-H5255) on AHC Biosensor, can bind Human TRAIL, His Tag with an affinity constant of 0.146 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

TR2-M52H5-ELISA

Immobilized Human TNFSF10 at 2 μg/mL (100 μL/well) can bind Mouse TRAIL R2, His Tag (Cat. No. TR2-M52H5) with a linear range of 0.039-0.625 μg/mL (QC tested).

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TRAIL R2 Molecule Synonym Name

TNFRSF10B,TRAILR2,TRAIL-R2,CD262,DR5,KILLER,TRICK2,ZTNFR9,TRICKB

TRAIL R2 Molecule Background

Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.