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TRAIL R2

TRAIL R2 Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
TR2-M52H5 Mouse Mouse TRAIL R2 / DR5 / TNFRSF10B Protein, His Tag
TR2-M52H5-structure
TR2-M52H5-sds
TR2-M52H5-elisa_1
TR2-H82E6 Human Biotinylated Human TRAIL R2 / DR5 / TNFRSF10B / CD262 Protein, His Tag, Avi Tag
TR2-H82E6-structure
TR2-H82E6-sds
TR2-H82E6-elisa_1
TR2-H5255 Human Human TRAIL R2 / DR5 / TNFRSF10B Protein, Fc Tag
TR2-H5255-structure
TR2-H5255-sds
TR2-H5255-elisa_1
TR2-H5229 Human Human TRAIL R2 / DR5 / TNFRSF10B Protein
TR2-H5229-structure
TR2-H5229-sds
TR2-H5229-elisa_1

TRAIL R2 Molecule Synonym Name

TNFRSF10B,TRAILR2,TRAIL-R2,CD262,DR5,KILLER,TRICK2,ZTNFR9,TRICKB

TRAIL R2 Molecule Background

Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.

TRAIL R2 References

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