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VEGF-B

VEGF-B Overview

English NameVascular endothelial growth factor BApproved Drugs1
Drugs in Clinical Trials4Target SynonymVEGF-related factor，VRF，VEGFB，VEGF-B，VEGFL，Vascular Endothelial Growth Factor B
Highest Development StageApproved
English NameVascular endothelial growth factor B
Target SynonymVEGF-related factor，VRF，VEGFB，VEGF-B，VEGFL，Vascular Endothelial Growth Factor B
Approved Drugs1
Drugs in Clinical Trials4
Highest Development StageApproved

VEGF-B Product List

  • Product Category

    Protein (1)

  • Product Status

    Launched (1)

  • Species

    Human (1)

  • Tag

    His Tag (1)

  • Conjugate

    Unconjugated (1)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeature
VE6-H5225
Human
HEK293
Human VEGF-B Protein, His Tag
Total: 1
  • 1

VEGF-B Background

Vascular endothelial growth factor B (VEGFB) is also known as VEGF-related factor (VRF), is a secreted O-glycosylated protein, which belongs to the PDGF/VEGF growth factor family. VEGFB is expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. VEGFB is growth factor for endothelial cells. VEGF-B seems to play a role only in the maintenance of newly formed blood vessels during pathological conditions. VEGF-B also plays an important role on several types of neurons. It is important for the protection of neurons in the retina and the cerebral cortex during stroke and of motoneurons during motor neuron diseases such as amyotrophic lateral sclerosis.VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.

VEGF-B Synonyms

VRF,VEGFL,VEGFB,VEGF-B

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
4D-1504D-150Phase 3 Clinical4d Molecular Therapeutics IncDiabetic macular oedema; Diabetic Retinopathy; Macular Degeneration; Wet Macular Degeneration
Details
Reflocibart2H-10; CSL-346Phase 2 ClinicalCsl LtdDiabetic Nephropathies
Details
PB-101PB-101Phase 1 ClinicalPanolos Bioscience IncCarcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Neoplasms; Solid tumours; Stomach Neoplasms
Details
EB-105EB-105Phase 1 ClinicalEluminex Biosciences (Suzhou) LtdDiabetic macular oedema; Diabetic Retinopathy
Details

Marketed Drug Information

English NameResearch CodeHighest Development StageCompanyEarliest Brand NameEarliest Approval CountryEarliest IndicationEarliest Approval CompanyEarliest Approval DateIndicationClinical Trial
Ziv-afliberceptAVE-0005; BAY-865321ApprovedRegeneron Pharmaceuticals Inc, SanofiZaltrapUnited StatesColorectal NeoplasmsSanofi-Aventis U.S. Llc2012-08-03Adenocarcinoma, Follicular; Ascites; Astrocytoma; Brain Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Genital Neoplasms, Female; Glioblastoma; Glioma; Gliosarcoma; Leiomyosarcoma; Leukemia; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Leukemia, Myelomonocytic, Chronic; Lung Diseases; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Metastatic breast cancer; Multiple Endocrine Neoplasia Type 1; Multiple Myeloma; Myelodysplastic Syndromes; Myelodysplastic-Myeloproliferative Diseases; Neoplasm Metastasis; Neoplasms; Oligodendroglioma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Retinal Vein Occlusion; Skin Melanoma; Small Cell Lung Carcinoma; Solid tumours; Thyroid
Details
  • Overview
  • Product List
  • Marketed Drug Information
  • Clinical Drug Information
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