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Your Position: Home > VEGF R1

VEGF R1

VEGF R1 Molecule Information

Name:Vascular endothelial growth factor receptor 1
Target Synonym:EC 2.7.10,Fms Related Receptor Tyrosine Kinase 1,EC:2.7.10.1,VEGFR1,Tyrosine-protein kinase receptor FLT,FRT,Fms-like tyrosine kinase 1,FLT1,Vascular Permeability Factor Receptor,Vascular Endothelial Growth Factor Receptor 1,Tyrosine-Protein Kinase FRT,FL
Number of Launched Drugs:12
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
VE1-R5257 Rhesus macaque Rhesus macaque VEGF R1 / Flt-1 Protein, Mouse IgG2a Fc Tag, low endotoxin
VE1-R5257-structure
VE1-R5257-sds
VE1-R5257-elisa_1
VE1-H82E3 Human Biotinylated Human VEGF R1 / Flt-1 Protein, His,Avitag™
VE1-H82E3-structure
VE1-H82E3-sds
VE1-H82E3-elisa_1
VE1-M5256 Mouse Mouse VEGF R1 / Flt-1 Protein, Mouse IgG2a Fc Tag, low endotoxin
VE1-M5256-structure
VE1-M5256-sds
VE1-M5256-elisa_1
VE1-H5220 Human Human VEGF R1 / Flt-1 Protein, His Tag
VE1-H5220-structure
VE1-H5220-sds
VE1-H5220-elisa_1

VEGF R1 Part of Bioactivity data

VE1-H82E3-ELISA
Biotinylated Human VEGF R1, His,AvitagBiotinylated Human VEGF R1, His,Avitag (Cat. No. VE1-H82E3) ELISA bioactivity

Immobilized Human VEGF165, Tag Free (Cat. No. VE5-H4210) at 2 μg/mL (100 μL/well) can bind Biotinylated Human VEGF R1, His,Avitag (Cat. No. VE1-H82E3) with a linear range of 1-31 ng/mL (QC tested).

Protocol
VE1-R5257-ELISA
Rhesus macaque VEGF R1, Mouse IgG2a Fc Tag, low endotoxinRhesus macaque VEGF R1, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. VE1-R5257) ELISA bioactivity

Immobilized Rhesus macaque PLGF (Cat. No. PGF-R52H0) at 0.5 μg/mL (100 μL/well) can bind Rhesus macaque VEGF R1, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. VE1-R5257) with a linear range of 0.6-10 ng/mL (QC tested).

Protocol

VEGF R1 Molecule Synonym Name

FLT,VEGFR1,FLT1

VEGF R1 Molecule Background

Vascular endothelial growth factor receptor 1 (VEGFR1) is also known as Fms-like tyrosine kinase 1 (FLT-1), Tyrosine-protein kinase receptor FLT, is a single-pass type I membrane protein and secreted protein which belongs to the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR1 is detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues and specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. VEGFR1 acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR1 may play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. VEGFR1 can promote endothelial cell proliferation, survival and angiogenesis in adulthood.

VEGF R1 References

VEGF R1 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Plitidepsin APLD Approved Pharma Mar Sa Aplidin Australia Multiple Myeloma s:4:"null"; 2018-12-11 Leukemia; Coronavirus Disease 2019 (COVID-19); Multiple Myeloma; Prostatic Neoplasms; Primary Myelofibrosis; Lymphoma Details
Pazopanib Hydrochloride GW-786034; SB-786034; GSK-786034; GW-786034B Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Patorma, Votrient Mainland China Carcinoma, Renal Cell s:26:"Novartis Pharma Schweiz Ag"; 2009-10-19 Osteosarcoma; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Melanoma; Carcinoma, Hepatocellular; Fallopian Tube Neoplasms; Glioma; Uterine Cervical Diseases; Colorectal Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Ovarian Neoplasms; Breast Neoplasms; Sarcoma; Small Cell Lung Carcinoma; Carcinoma, Ovarian Epithelial; Hemangiosarcoma; Carcinoma, Renal Cell; Solid tumours; Uterine Diseases; Chondrosarcoma; Telangiectasia, Hereditary Hemorrhagic Details
Axitinib AG-013736; PF-01367866; AG-13736 Approved Pfizer Pharmaceuticals Ltd (China) 英立达, Inlyta Mainland China Carcinoma, Renal Cell s:21:"Pfizer Europe Ma Eeig"; 2012-01-27 Kidney Neoplasms; Solid tumours; Carcinoma, Renal Cell; Carcinoma; Skin Neoplasms; Myelodysplastic Syndromes; Endometriosis; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Lung Neoplasms; Thyroid Neoplasms; Carcinoma, Hepatocellular; Melanoma; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Macular Degeneration Details
Tivozanib AV-951; KRN-951; ASP-4130; Kil-8951 Approved Kyowa Hakko Kirin Co Ltd Fotivda United States Carcinoma, Renal Cell s:24:"Aveo Pharmaceuticals Inc"; 2017-08-24 Solid tumours; Carcinoma, Renal Cell; Hepatic Insufficiency; Carcinoma, Non-Small-Cell Lung Details
Nintedanib Esylate BIBF-1120 Approved C.H. Boehringer Sohn Ag & Co. Kg Ofev, Vargatef Mainland China Idiopathic Pulmonary Fibrosis s:39:"Boehringer Ingelheim International Gmbh"; 2014-10-15 Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Scleroderma, Systemic; Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Pulmonary Fibrosis; Multiple Myeloma; Prostatic Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Hepatic Insufficiency; Genital Neoplasms, Female; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
Cabozantinib S-malate XL-184; BMS-907351 Approved Exelixis Inc Cometriq, Cabometyx Japan Carcinoma, Renal Cell s:6:"Takeda"; 2012-11-29 Solid tumours; Stomach Neoplasms; Carcinoma, Renal Cell; Pain; Esophageal Neoplasms; Kidney Diseases; Glioblastoma; Prostatic Neoplasms; Colorectal Neoplasms; Hepatic Insufficiency; Astrocytoma; Thyroid Neoplasms; Lymphoma; Carcinoma, Neuroendocrine; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
Sorafenib Tosylate NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085 Approved Onyx Pharmaceuticals Inc 多吉美, Nexavar United States Thyroid Neoplasms s:14:"Bayer Hlthcare"; 2005-12-01 Liver Diseases; Neoplasm Metastasis; Fasting; Melanoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Lung Neoplasms; Thyroid Neoplasms; Hepatitis C; Hepatitis B; Breast Neoplasms; Liver Neoplasms; Kidney Diseases; Neoplasms; Pancreatic Neoplasms; Carcinoma; Carcinoma, Renal Cell; Kidney Neoplasms; Solid tumours; Ovarian Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive Details
Regorafenib Monohydrate BAY-73-4506; DAST Approved Bayer Ag Stivarga, Resihance Mainland China Gastrointestinal Stromal Tumors s:15:"Bayer Pharma Ag"; 2012-09-27 Solid tumours; Rectal Neoplasms; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Carcinoma, Hepatocellular; Gastrointestinal Neoplasms Details
Sunitinib Malate SU-11248; SU-010398; PHA-290940; PNU-290940; PHA-290940AD; PNU-290940AD; SU-011248-L-malate salt; GB-102 Approved Pfizer Pharmaceuticals Ltd (China) 索坦, Sutent Japan Pancreatic neuroendocrine tumors (pNET) s:10:"Pfizer Inc"; 2006-01-26 Prostatic Neoplasms; Retinal Vein Occlusion; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Urogenital Neoplasms; Urologic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Breast Neoplasms; Diabetic macular oedema; Kidney Neoplasms; Urologic Diseases; Neuroendocrine Tumors; Kidney Diseases; Pancreatic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Stomach Neoplasms; Carcinoma, Islet Cell; Carcinoma, Renal Cell; Solid tumours; Liver Neoplasms Details
Lenvatinib Mesylate ER-203492-00; E-7080 Approved Eisai Co Ltd Kisplyx, Lenvima, Lenvima/Kisplyx, 乐卫玛 Mainland China Carcinoma, Hepatocellular s:16:"Eisai Europe Ltd"; 2015-02-13 Kidney Diseases; Melanoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Endometrial Neoplasms; Lymphoma; Thyroid Neoplasms; Hepatic Insufficiency; Liver Diseases; Solid tumours; Thyroid Carcinoma, Anaplastic; Adenocarcinoma of Lung; Renal Insufficiency; Carcinoma, Renal Cell; Ovarian Neoplasms; Biliary Tract Neoplasms; Liver Neoplasms Details
Fruquintinib HMPL-013 Approved Hutchison Medipharma Ltd 爱优特, Elunate Mainland China Colorectal Neoplasms s:44:"Hutchison Huangpu Medicine (Shanghai) Co Ltd"; 2018-09-04 Solid tumours; Rectal Neoplasms; Colonic Neoplasms; Triple Negative Breast Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Anlotinib Dihydrochloride AL-3818 Approved Advenchen Laboratories, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 福可维 Mainland China Small Cell Lung Carcinoma s:47:"Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd"; 2018-05-08 Gallbladder Neoplasms; Nasopharyngeal Carcinoma; Gastrointestinal Stromal Tumors; Peritoneal Neoplasms; Colorectal Neoplasms; Bone Neoplasms; Urologic Neoplasms; Endometrial Neoplasms; Thyroid Neoplasms; Esophageal Squamous Cell Carcinoma; Lung Neoplasms; Bile Duct Diseases; Sarcoma, Alveolar Soft Part; Fallopian Tube Neoplasms; Carcinoma, Hepatocellular; Melanoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Adenocarcinoma; Osteoma; Gastrointestinal Neoplasms; Carcinoma, Ovarian Epithelial; Leiomyosarcoma; Biliary Tract Neoplasms; Solid tumours; Liver Neoplasms; Head and Neck Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Esophageal Neoplasms; Thoracic Neoplasms; Genital Diseases, Female; Ovarian Neoplasms; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Lymphoma, Large B-Cell, Diffuse; Sarcoma, Synovial; Neuroendocrine Tumors; Microsatellite instability-high cancer; Sarcoma; Medullary thyroid cancer (MTC); Cholangiocarcinoma Details

VEGF R1 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
OCV-101 OCV-101; OTS-11101 Phase 2 Clinical Oncotherapy Science Pancreatic Neoplasms Details
VEGFR-1/2 peptide vaccine (Keio University) Phase 2 Clinical Keio University Neurofibromatoses; Brain Neoplasms; Glioma Details
Glesatinib MG-90265; MGCD-265; MG-90265X; 7Q29OXD98N; MG-90265H9; MG-90265gly Phase 2 Clinical Mirati Therapeutics Carcinoma, Non-Small-Cell Lung Details
Icrucumab 18-F-1; IMC-18-F-1; LY-3012212 Phase 2 Clinical Imclone Systems, Eli Lilly And Company Rectal Neoplasms; Colonic Neoplasms; Breast Neoplasms; Urethral Neoplasms; Colorectal Neoplasms; Urologic Neoplasms; Ureteral Neoplasms; Urogenital Neoplasms Details
Sorafenib/MG-005 MGD-1509 Phase 2 Clinical Metagone Biotech, Tri-Service General Hospital Neoplasms Details
Hydroxychloroquine/Sorafenib Phase 1 Clinical Vg Life Sciences Ovarian Neoplasms Details
Cediranib AZD2171; AZD-2171; NSC-732208 Phase 2 Clinical Astrazeneca Plc Glioblastoma; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Gastrointestinal Stromal Tumors; Hepatic Insufficiency; Colorectal Neoplasms; Sarcoma; Prostatic Neoplasms; Brain Neoplasms; Breast Neoplasms; Solid tumours; Carcinoma, Renal Cell; Carcinoma; Stomach Neoplasms; Leukemia; Head and Neck Neoplasms; Liver Neoplasms; Ovarian Neoplasms; Biliary Tract Neoplasms Details
Chiauranib CS-2164 Phase 2 Clinical Shenzhen Chipscreen Biosciences Co Ltd Ovarian Neoplasms; Solid tumours; Small Cell Lung Carcinoma; Lymphoma, Non-Hodgkin; Carcinoma, Hepatocellular Details
Dovitinib TKI-258; CHIR-258; GFKI-258; CHIR-258LC; NVP-TKI258 Phase 2 Clinical Novartis Pharma Ag Carcinoma, Adenoid Cystic; Carcinoma, Endometrioid; Carcinoma, Non-Small-Cell Lung; Melanoma; Carcinoma, Hepatocellular; Thyroid Neoplasms; Leukemia, Myeloid, Acute; Endometrial Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Hepatic Insufficiency; Prostatic Neoplasms; Breast Neoplasms; Solid tumours; Adrenocortical Carcinoma; Multiple Myeloma; Pancreatic Neoplasms; Glioblastoma; Adenocarcinoma, Scirrhous; Carcinoma; Carcinoma, Renal Cell; Stomach Neoplasms; Liver Neoplasms; Linitis Plastica; Stomach Diseases Details
Sitravatinib MG-516; MG-91516; MGCD-516 Phase 3 Clinical Mirati Therapeutics Solid tumours; Carcinoma; Carcinoma, Renal Cell; Neoplasms; Carcinoma, Transitional Cell; Hepatic Insufficiency; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms Details
Lucitanib AL-3810; CO-3810; S-80881 Phase 3 Clinical Advenchen Laboratories Nanjing Ltd Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Carcinoma, Transitional Cell; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Breast Neoplasms; Nasopharyngeal Carcinoma; Thymus Neoplasms; Genital Neoplasms, Female; Colorectal Neoplasms; Carcinoma, Small Cell; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details

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