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VLDL R

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Cat. No. Species Product Description Structure Purity Feature
VLR-H5227 Human Human VLDL R Protein, His Tag
VLR-H5227-structure
VLR-H5227-sds
VLR-H5227-elisa_1

VLDL R Part of Bioactivity data

VLR-H5227-ELISA
Human VLDL R, His TagHuman VLDL R, His Tag (Cat. No. VLR-H5227) ELISA bioactivity

Immobilized Human VLDL R, His Tag (Cat. No. VLR-H5227) at 5 μg/mL (100 μL/well) can bind Biotinylated Human PCSK9, His Tag (Cat. No. PC9-H82E7) with a linear range of 10-156 ng/mL (QC tested).

VLDL R Molecule Synonym Name

VLDLR,RP11-320E16.1,CHRMQ1,FLJ35024,VLDLRCH,VLDL receptor

VLDL R Molecule Background

The very-low-density-lipoprotein receptor (VLDL-R) is a lipoprotein receptor that shows considerable similarity to the lowdensity-lipoprotein receptor. VLDL R is a 130 kDa type I transmembrane protein in the LDL receptor family that plays a significant role in lipid metabolism and in nervous system development and function .This receptor has been suggested to be important for the metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, such as very-low-densitylipoprotein (VLDL), beta-migrating VLDL and intermediate-density lipoprotein. It is also one of the receptors of reelin, an extracellular matrix protein which regulates the processes of neuronal migration and synaptic plasticity. In humans, the VLDL-R is encoded by the VLDLR gene. A rare neurological disorder first described in the 1970s under the name "disequilibrium syndrome" is now considered to be caused by the disruption of VLDLR gene. The disorder was renamed VLDLR-associated cerebellar hypoplasia (VLDLRCH) after a 2005 study. It is associated with parental consanguinity and found in secluded communities such as the Hutterites. VLDLRCH is one of the two known genetic disorders caused by a disruption of reelin signaling pathway, along with Norman-Roberts syndrome.

VLDL R References

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