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Your Position: Home > Vitronectin

Vitronectin

Brief Information

Name:Vitronectin
Target Synonym:Somatomedin B,Epibolin,Serum Spreading Factor,VNT,S-protein,Complement S-Protein,Vitronectin,V75,VN,Serum-spreading factor,Vitronectin (Serum Spreading Factor, Somatomedin B, Complement S-Protein)
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Cat. No. Species Product Description Structure Purity Feature
VIN-H5119 Human Human Vitronectin / VTN Protein, Tag Free
VIN-H5119-structure
VIN-H5119-sds
VIN-H8113 Human Biotinylated Human Vitronectin / VTN Protein, Tag Free, ultra sensitivity (primary amine labeling)
VIN-H8113-structure
VIN-H8113-sds
ACRO Quality

Part of Bioactivity data

VIN-H8113-ELISA
Vitronectin ELISA

Immobilized Biotinylated Human Vitronectin, Tag Free, primary amine labeling (Cat. No. VIN-H8113) at 1 μg/mL (100 μL/well) on Streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate, can bind Human ITGAV&ITGB5 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT5-H52W5) with a linear range of 0.156-1.25 μg/mL (QC tested).

Protocol
VIN-H5119-ELISA
Human Vitronectin, Tag FreeHuman Vitronectin, Tag Free (Cat. No. VIN-H5119) ELISA bioactivity

Immobilized Human Vitronectin, Tag Free (Cat. No. VIN-H5119) at 2 μg/mL (100 μL/well) can bind Human ITGAV&ITGB3 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT3-H52E3) with a linear range of 0.078-1.25 μg/mL (QC tested).

Protocol

Synonym Name

VTN,V75,VN,Vitronectin,S-protein,Serum-spreading factor

Background

Vitronectin is also known as S-protein, VN, VTN, V75. Vitronectin, a multifunctional glycoprotein, is involved in coagulation, inhibition of the formation of the membrane attack complex (MAC), cell adhesion and migration, wound healing, and tissue remodeling. The primary cellular source of vitronectin is hepatocytes. Blocking of Hic(a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In addition, Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

Clinical and Translational Updates

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