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Your Position: Home > Vitronectin


Brief Information

Target Synonym:Vitronectin,V75,VN,Serum-spreading factor,Vitronectin (Serum Spreading Factor, Somatomedin B, Complement S-Protein),Somatomedin B,Epibolin,Serum Spreading Factor,VNT,S-protein,Complement S-Protein,Protein S
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Cat. No. Species Product Description Structure Purity Feature
VIN-H52H3 Human Human Vitronectin / VTN Protein, Tag Free
ACRO Quality

Part of Bioactivity data

 Vitronectin SPR

Human ITGAV&ITGB3 Heterodimer Protein, His Tag&Tag Free IT3-H52E3 (Cat. No. IT3-H52E3) immobilized on CM5 Chip can bind Human Vitronectin Protein, Tag Free (Cat. No. VIN-H52H3) with an affinity constant of 74.1 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

 Vitronectin ELISA

Immobilized Human Vitronectin Protein, Tag Free (Cat. No. VIN-H52H3) at 2 μg/mL (100 μL/well) can bind Human ITGAV&ITGB5 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT5-H52W5) with a linear range of 0.2-8 ng/mL (QC tested).

Synonym Name

VTN,V75,VN,Vitronectin,S-protein,Serum-spreading factor


Vitronectin is also known as S-protein, VN, VTN, V75. Vitronectin, a multifunctional glycoprotein, is involved in coagulation, inhibition of the formation of the membrane attack complex (MAC), cell adhesion and migration, wound healing, and tissue remodeling. The primary cellular source of vitronectin is hepatocytes. Blocking of Hic(a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In addition, Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

Clinical and Translational Updates

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