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PDGF R alpha

Brief Information

Name:Platelet-derived growth factor receptor alpha
Target Synonym:RHEPDGFRA,Platelet-derived growth factor alpha receptor,PDGFRA,Alpha-type platelet-derived growth factor receptor,PDGFR-alpha,CD140a antigen,CD140a,Platelet Derived Growth Factor Receptor Alpha,Platelet-Derived Growth Factor Receptor, Alpha Polypeptide,Pl
Number of Launched Drugs:8
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Approved

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By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
PDA-H52H7 Human Human PDGF R alpha / PDGFRA Protein, His Tag
PDA-H52H7-structure
PDA-H52H7-sds
PDA-H52H7-elisa_1

Synonym Name

PDGFRA,CD140A,PDGFR2,RHEPDGFRA,MGC74795

Background

PDGFRA(platelet-derived growth factor receptor A), also termed PDGFR?(platelet-derived growth factor receptor ?), is a receptor located on the surface of a wide range of cell types. This receptor binds to certain isoforms of platelet-derived growth factors (PDGFs) and thereby becomes active in stimulating cell signaling pathways that elicit responses such as cellular growth and differentiation. The receptor is critical for the development of certain tissues and organs during embryogenesis and for the maintenance of these tissues and organs, particularly hematologic tissues, throughout life. Mutations in the gene which codes for PDGFRA, are associated with an array of clinically significant neoplasms.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Olaratumab IMC-3G3; LY-3012207 Approved Eli Lilly And Company Lartruvo United States Sarcoma Eli Lilly And Co Ltd 2016-10-19 Solid tumours; Sarcoma; Prostatic Neoplasms; Gastrointestinal Stromal Tumors; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
Ripretinib DCC-2618 Approved Deciphera Qinlock, 擎乐 Mainland China Gastrointestinal Stromal Tumors Zai Lab (Shanghai) Co Ltd 2020-05-15 Mastocytosis, Systemic; Gastrointestinal Stromal Tumors Details
Pazopanib Hydrochloride GW-786034; SB-786034; GSK-786034; GW-786034B Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Patorma, Votrient Mainland China Carcinoma, Renal Cell Novartis Pharma Schweiz Ag 2009-10-19 Osteosarcoma; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Melanoma; Carcinoma, Hepatocellular; Fallopian Tube Neoplasms; Glioma; Peritoneal Neoplasms; Colorectal Neoplasms; Prostatic Neoplasms; Ovarian Neoplasms; Breast Neoplasms; Sarcoma; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Hemangiosarcoma; Carcinoma, Renal Cell; Solid tumours; Chondrosarcoma; Telangiectasia, Hereditary Hemorrhagic Details
Regorafenib Monohydrate BAY-73-4506; DAST Approved Bayer Ag Stivarga, Resihance Mainland China Gastrointestinal Stromal Tumors Bayer Pharma Ag 2012-09-27 Solid tumours; Rectal Neoplasms; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Carcinoma, Hepatocellular; Gastrointestinal Neoplasms Details
Nintedanib Esylate BIBF-1120 Approved C.H. Boehringer Sohn Ag & Co. Kg Ofev, Vargatef Mainland China Idiopathic Pulmonary Fibrosis Boehringer Ingelheim International Gmbh 2014-10-15 Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Scleroderma, Systemic; Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis; Lung Diseases, Interstitial; Multiple Myeloma; Prostatic Neoplasms; Peritoneal Neoplasms; Hepatic Insufficiency; Genital Neoplasms, Female; Colorectal Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
Avapritinib BLU-285; CS-3007 Approved Blueprint Medicines Corp Ayvakit, Ayvakyt, 泰吉华 United States Leukemia, Mast-Cell; Mastocytosis, Systemic Blueprint Medicines 2020-01-09 Hematologic Neoplasms; Solid tumours; Mastocytosis, Systemic; Leukemia, Mast-Cell; Central Nervous System Neoplasms; Gastrointestinal Stromal Tumors Details
Lenvatinib Mesylate ER-203492-00; E-7080 Approved Eisai Co Ltd Kisplyx, Lenvima, Lenvima/Kisplyx, 乐卫玛 United States Endometrial Neoplasms Eisai Inc 2015-02-13 Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Gallbladder Neoplasms; Lymphoma; Endometrial Neoplasms; Thyroid Neoplasms; Hepatic Insufficiency; Cholangiocarcinoma; Sarcoma; Liver Diseases; Liver Neoplasms; Triple Negative Breast Neoplasms; Kidney Diseases; Small Cell Lung Carcinoma; Thyroid Carcinoma, Anaplastic; Adenocarcinoma of Lung; Esophageal Neoplasms; Renal Insufficiency; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Biliary Tract Neoplasms; Solid tumours Details
Sunitinib Malate PHA-290940; SU-010398; SU-11248; GB-102; PNU-290940; SU-011248-L-malate salt; PNU-290940AD; PHA-290940AD Approved Pfizer Pharmaceuticals Ltd (China) Sutent, 索坦 Japan Pancreatic neuroendocrine tumors (pNET) Pfizer Inc 2006-01-26 Diabetic macular oedema; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Retinal Vein Occlusion; Carcinoma, Hepatocellular; Urogenital Neoplasms; Urologic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Prostatic Neoplasms; Breast Neoplasms; Kidney Neoplasms; Neuroendocrine Tumors; Urologic Diseases; Kidney Diseases; Pancreatic neuroendocrine tumors (pNET); Pancreatic Neoplasms; Carcinoma, Islet Cell; Stomach Neoplasms; Carcinoma, Renal Cell; Solid tumours; Liver Neoplasms Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Anti-CMV monoclonal antibody (Humabs BioMed/Institute for Research in Biomedicine) Phase 2 Clinical Humabs Biomed, Institute For Research In Biomedicine Cytomegalovirus Infections Details
Crenolanib Besylate ARO-002; CP-868596; ARO-002-26; IND-112201; CP-868596-26 Phase 3 Clinical Pfizer Pharmaceuticals Ltd (China) Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute; Glioma; Carcinoma, Non-Small-Cell Lung Details
Lucitanib AL-3810; CO-3810; S-80881 Phase 3 Clinical Advenchen Laboratories Nanjing Ltd Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Carcinoma, Transitional Cell; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Breast Neoplasms; Nasopharyngeal Carcinoma; Colorectal Neoplasms; Thymus Neoplasms; Genital Neoplasms, Female; Carcinoma, Small Cell; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details
Chiauranib CS-2164 Phase 3 Clinical Shenzhen Chipscreen Biosciences Co Ltd Ovarian Neoplasms; Solid tumours; Small Cell Lung Carcinoma; Lymphoma, Non-Hodgkin; Carcinoma, Hepatocellular Details

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