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CD8 alpha

Brief Information

Name:Cluster of differentiation 8
Target Synonym:CD8 Antigens
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:11
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

 CD8 alpha ELISA

Immobilized Human CD8 alpha, His Tag (Cat. No. CDA-H52H3) at 5 μg/mL (100 μL/well) can bind Anti-CD8 alpha Antibody, Human IgG1 with a linear range of 1-2 ng/mL (QC tested).

CD8 alpha MALS images

The purity of Cynomolgus CD8 alpha Protein, His Tag (Cat. No. CDA-C52H4) is more than 95% and the molecular weight of this protein is around 46-56 kDa verified by SEC-MALS.

Synonym Name



Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
GRANITE GRANITE-001; GRT-C901/GRT-R902 Phase 3 Clinical Bristol-Myers Squibb Company, Gritstone Bio Inc Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Transitional Cell; Colonic Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
89Zr-Df-crefmirlimab IAB-22-M2C Phase 3 Clinical Imaginab Inc Solid tumours; Carcinoma, Merkel Cell; Carcinoma, Renal Cell; Multiple Sclerosis; Lymphoma; Leukoencephalopathy, Progressive Multifocal; Melanoma; Carcinoma, Non-Small-Cell Lung Details
RB-0003 RB-0003; BNT-111 Phase 2 Clinical Biontech Se, Tron Melanoma Details
GEN-009 GEN-009 Phase 2 Clinical Genocea Biosciences Inc Skin Melanoma; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Carcinoma, Non-Small-Cell Lung Details
VE-800 VE-800 Phase 2 Clinical Vedanta Biosciences Inc Esophageal Neoplasms; Stomach Neoplasms; Colorectal Neoplasms; Adenocarcinoma; Melanoma; Neoplasm Metastasis Details
EBViNT Cell (Eutilex) Phase 2 Clinical Eutilex Lymphoma, Extranodal NK-T-Cell Details
ZED88082A ZED88082A Phase 2 Clinical Umcg The University Medical Center Groningen Neoplasms; Neoplasm Metastasis Details
NY-ESO-1-specific autologous CD8+ T-cell therapy (Fred Hutchinson Cancer Research Center) Phase 1 Clinical Fred Hutchinson Cancer Research Center, National Cancer Institute Liposarcoma; Sarcoma, Synovial; Sarcoma Details
Tcrx T cell Therapy(Second Affiliated Hospital School Of Zhejiang University School Of Medicine) Phase 1 Clinical Second Affiliated Hospital School Of Zhejiang University School Of Medicine Esophageal Neoplasms; Stomach Neoplasms Details
SCRI-E2CAR_EGFRtv1 SCRI-E2CAR_EGFRtv1 Phase 1 Clinical Umoja BioPharma Inc Osteosarcoma Details
68-Ga-NODAGA-SNA-006 SNA-006; 68-Ga-NODAGA-SNA-006 Phase 1 Clinical Smartnuclide Biopharma Solid tumours Details

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