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CD8 alpha

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Part of Bioactivity data

CDA-H82E3-ELISA
Biotinylated Human CD8 alpha, His,AvitagBiotinylated Human CD8 alpha, His,Avitag (Cat. No. CDA-H82E3) ELISA bioactivity

Immobilized Biotinylated Human CD8 alpha, His,Avitag (Cat. No. CDA-H82E3) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate. can bind Anti-CD8 alpha Antibody, Mouse IgG2a (clone: OKT8) with a linear range of 0.2-2 ng/mL (QC tested).

CDA-H52H3-MALS-HPLC
Human CD8 alpha, His Tag (Cat. No. ) MALS images

The purity of Human CD8 alpha, His Tag (Cat. No. CDA-H52H3) was more than 90% and the molecular weight of this protein is around 50-60 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human CD8 alpha, His TagHuman CD8 alpha, His Tag (Cat. No. CDA-H52H3) ELISA bioactivity

Immobilized Human CD8 alpha, His Tag (Cat. No. CDA-H52H3) at 5 μg/mL (100 μL/well) can bind Anti-CD8 alpha Antibody, Human IgG1 with a linear range of 1-2 ng/mL (QC tested).

Synonym Name

CD8A,CD8,Leu2,MAL,p32

Background

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

Clinical and Translational Updates

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