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MCAM Molecule Information

Name:Melanoma cell adhesion molecule
Target Synonym:Melanoma cell adhesion molecule;MUC18;CD146;Cell surface glycoprotein P1H12;Melanoma-associated antigen A32;S-endo 1 endothelial-associated antigen;MCAM;Melanoma-associated antigen MUC18
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
CD6-H5229 Human Human MCAM / CD146 Protein, His Tag

MCAM Molecule Synonym Name


MCAM Molecule Background

CD146 is also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.

MCAM References

MCAM Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Imaprelimab PRX-003 Phase Ⅰ Neotope Biosciences, Onclave Therapeutics, Prothena Psoriasis Details
MG1MA3 MG1-MAGEA3; MG1-MA3; Ad-MG1; Ad-MAGEA3 Phase Ⅱ University of Ottawa Heart Institute, McMaster University, Children's Hospital of Eastern Ontario, Turnstone Biologics Solid tumours Details
Anti-MUC18 monoclonal antibody Phase Ⅰ Abgenix Melanoma Details

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