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Your Position: Home > MCAM

MCAM

Brief Information

Name:Melanoma cell adhesion molecule
Target Synonym:METCAM,CD146,Melanoma cell adhesion molecule,MCAM,Cell surface glycoprotein MUC18,S-Endo 1 Endothelial-Associated Antigen,Melanoma-Associated Antigen MUC18,Melanoma-Associated Antigen A32,Gicerin,MUC18,CD146 Antigen,Cell surface glycoprotein P1H12,Melanoma Adhesion Molecule,MelCAM,HEMCAM
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Discontinued

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Part of Bioactivity data

MCM-C52H3-MALS-HPLC
Cynomolgus MCAM, His Tag (Cat. No. ) MALS images

The purity of Cynomolgus MCAM, His Tag (Cat. No. MCM-C52H3) is more than 90% and the molecular weight of this protein is around 80-90 kDa verified by SEC-MALS.

  • Background
    CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Synonym Name

MCAM,CD146,MUC18

Background

CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle.CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells.As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Imaprelimab PRX-003 Neotope Biosciences, Onclave Therapeutics Details

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