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MCAM Molecule Information

Name:Melanoma cell adhesion molecule
Target Synonym:HEMCAM,METCAM,CD146,Melanoma cell adhesion molecule,MCAM,Cell surface glycoprotein MUC18,S-Endo 1 Endothelial-Associated Antigen,Melanoma-Associated Antigen MUC18,Melanoma-Associated Antigen A32,Gicerin,MUC18,CD146 Antigen,MelCAM,Cell surface glycoprotein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Discontinued

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Cat. No. Species Product Description Structure Purity Feature
CD6-H5229 Human Human MCAM / CD146 Protein, His Tag

MCAM Molecule Synonym Name


MCAM Molecule Background

CD146 is also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.

MCAM References

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