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Your Position: Home > Activin RIIA

Activin RIIA

Brief Information

Name:Activin receptor type-2A
Target Synonym:Activin receptor type IIA,ACTR-IIA,ACTRIIA,ACVR2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
ACA-H5269 Human Human Activin RIIA / ACVR2A Protein, Fc Tag
ACA-H5269-structure
ACA-H5269-sds
ACRO Quality

Part of Bioactivity data

ACA-H5269-SPR
 Activin RIIA ELISA

Immobilized Human Activin A, premium grade (Cat. No. ACA-H421b) at 5 μg/mL (100 μL/well) can bind Human ACVR2A, Fc Tag (Cat. No. ACA-H5269) with a linear range of 0.4-25 ng/mL (QC tested).

Customer Reviews

Synonym Name

Activin receptor type IIA,ACTRIIA

Background

Activin receptor type-2A (ACVR2A) is also known as Activin receptor type IIA, ACTR-IIA, ACTRIIA and ACVR2,which is single-pass type I membrane protein. ACVR2A belongs to the protein kinase superfamily,TKL Ser/Thr protein kinase family and TGFB receptor subfamily.On ligand binding,ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.ACVR2A is Receptor for activin A, activin B and inhibin A as well. Several type I I activin receptors have been identified and bind to different activins with different affinities.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
LAE-102 LAE-102 Phase 2 Clinical Laekna Therapeutics Shanghai Co Ltd Non-alcoholic Fatty Liver Disease; Carcinoma, Non-Small-Cell Lung Details

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