MIF
MIF Molecule Information
Name:Macrophage migration inhibitory factor
Target Synonym:L-dopachrome tautomerase;Macrophage migration inhibitory factor;Glycosylation-inhibiting factor;L-dopachrome isomerase;GLIF ;GIF;MMIF;MIF;Phenylpyruvate tautomerase
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase ?
MIF Molecule Synonym Name
MIF,GLIF,MMIF,GIF
MIF Molecule Background
Macrophage migration inhibitory factor(MIF) is also known as Glycosylation-inhibiting factor(GIF), L-dopachrome isomerase, L-dopachrome tautomerase, Phenylpyruvate tautomerase. Interacts with CXCR2 extracellular domain, CD74 extracellular domain, COPS5 and BNIPL. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
MIF References
MIF Clinical Drug Information
Name |
Research Code |
Research Phase |
Company |
Indications |
Clinical Trials |
CPSI-2705 |
CPS1-2705 |
Preclinical |
Cytokine PharmaSciences |
Infectious disease, Immunological disorders |
Details
|
Imalumab |
BAX-069; BAX-69 |
Phase Ⅱ |
Cytokine PharmaSciences, Baxalta |
Lupus nephritis, Solid tumours, Colorectal cancer, Malignant Ascites |
Details
|
R-ISO-15 |
|
Preclinical |
Ferring Pharmaceuticals |
Sepsis |
Details
|
CBX-21404 |
CBX-21404,CBX21404 |
Preclinical |
Ciblex |
Autoimmune diseases, Prostate cancer, Breast cancer, Inflammation |
Details
|